Results 21 to 30 of about 129,894 (264)

A Proteomics and Transcriptomics Investigation of the Venom from the Barychelid Spider Trittame loki (Brush-Foot Trapdoor) [PDF]

Toxins, 2013
Although known for their potent venom and ability to prey upon both invertebrate and vertebrate species, the Barychelidae spider family has been entirely neglected by toxinologists. In striking contrast, the sister family Theraphosidae (commonly known as
Eivind A. B. Undheim, Kartik Sunagar, Volker Herzig, Laurence Kely, Dolyce H. W. Low, Timothy N. W. Jackson, Alun Jones, Nyoman Kurniawan, Glenn F. King, Syed A. Ali, Agostino Antunes, Tim Ruder, Bryan G. Fry   +12 more
doaj   +2 more sources

Spider venom-derived peptide induces hyperalgesia in Na_v1.7 knockout mice by activating Na_v1.9 channels. [PDF]

Nat Commun, 2020
The sodium channels Nav1.7, Nav1.8 and Nav1.9 are critical for pain perception in peripheral nociceptors. Loss of function of Nav1.7 leads to congenital insensitivity to pain in humans.
Zhou X, Ma T, Yang L, Peng S, Li L, Wang Z, Xiao Z, Zhang Q, Wang L, Huang Y, Chen M, Liang S, Zhang X, Liu JY, Liu Z.   +14 more
europepmc   +2 more sources

Spider venom administration impairs glioblastoma growth and modulates immune response in a non-clinical model. [PDF]

Sci Rep, 2020
Molecules from animal venoms are promising candidates for the development of new drugs. Previous in vitro studies have shown that the venom of the spider Phoneutria nigriventer (PnV) is a potential source of antineoplastic components with activity in ...
Bonfanti AP, Barreto N, Munhoz J, Caballero M, Cordeiro G, Rocha-E-Silva T, Sutti R, Moura F, Brunetto S, Ramos CD, Thomé R, Verinaud L, Rapôso C.   +12 more
europepmc   +2 more sources

Venom-gland transcriptomics and venom proteomics of the Tibellus oblongus spider

Scientific Data, 2023
The Tibellus oblongus spider is an active hunter that does not spin webs and remains highly underinvestigated in terms of the venom composition. Here, we describe venom glands transcriptome and venom proteome analysis for unveiling the polypeptide ...
Yuliya Korolkova, Alexander Mikov, Anna Lobas, Elizaveta Solovyeva, Alexey Surin, Yaroslav Andreev, Mikhail Gorshkov, Sergey Kozlov   +7 more
doaj   +3 more sources

Spider venom peptides as potential drug candidates due to their anticancer and antinociceptive activities. [PDF]

J Venom Anim Toxins Incl Trop Dis, 2019
Spider venoms are known to contain proteins and polypeptides that perform various functions including antimicrobial, neurotoxic, analgesic, cytotoxic, necrotic, and hemagglutinic activities.
Wu T, Wang M, Wu W, Luo Q, Jiang L, Tao H, Deng M.   +6 more
europepmc   +2 more sources

TCTP from Loxosceles Intermedia (Brown Spider) Venom Contributes to the Allergic and Inflammatory Response of Cutaneous Loxoscelism. [PDF]

Cells, 2019
LiTCTP is a toxin from the Translationally Controlled Tumor Protein (TCTP) family identified in Loxosceles brown spider venoms. These proteins are known as histamine-releasing factors (HRF). TCTPs participate in allergic and anaphylactic reactions, which
Boia-Ferreira M, Moreno KG, Basílio ABC, da Silva LP, Vuitika L, Soley B, Wille ACM, Donatti L, Barbaro KC, Chaim OM, Gremski LH, Veiga SS, Senff-Ribeiro A.   +12 more
europepmc   +2 more sources

Loxosceles gaucho Spider Venom: An Untapped Source of Antimicrobial Agents. [PDF]

Toxins (Basel), 2018
The remarkable ability of microorganisms to develop resistance to conventional antibiotics is one of the biggest challenges that the pharmaceutical industry currently faces.
Segura-Ramírez PJ, Silva Júnior PI.
europepmc   +2 more sources

Venomic and pharmacological activity of Acanthoscurria paulensis (Theraphosidae) spider venom

Toxicon, 2012
In the present study we conducted proteomic and pharmacological characterizations of the venom extracted from the Brazilian tarantula Acanthoscurria paulensis, and evaluated the cardiotoxicity of its two main fractions. The molecular masses of the venom components were identified by mass spectrometry (MALDI-TOF-MS) after chromatographic separation ...
Caroline Barbosa Farias Mourão, Fagner Neves Oliveira, Andréa Cruz e Carvalho, Claudia Arenas, Harry Morales Duque, Jacqueline Coimbra Gonçalves, Jéssica K. A. Macêdo, Priscilla Galante, Carlos Schwartz, Márcia Renata Mortari, Maria de Fátima M. Almeida Santos, Elisabeth F. Schwartz   +11 more
openalex   +4 more sources

The Spider Venom Peptide Lycosin-II Has Potent Antimicrobial Activity against Clinically Isolated Bacteria [PDF]

Toxins, 2016
Antimicrobial peptides have been accepted as excellent candidates for developing novel antibiotics against drug-resistant bacteria. Recent studies indicate that spider venoms are the source for the identification of novel antimicrobial peptides.
Yongjun Wang, Ling Wang, Huali Yang, Haoliang Xiao, Athar Farooq, Zhonghua Liu, Min Hu, Xiaoliu Shi   +7 more
openalex   +2 more sources

Latarcins: versatile spider venom peptides

Cellular and Molecular Life Sciences, 2015
Arthropod venoms feature the presence of cytolytic peptides believed to act synergetically with neurotoxins to paralyze prey or deter aggressors. Many of them are linear, i.e., lack disulfide bonds. When isolated from the venom, or obtained by other means, these peptides exhibit common properties.
P. Dubovskii, A. Vassilevski, S. Kozlov, A. Feofanov, E. Grishin, R. Efremov   +5 more
semanticscholar   +4 more sources