Results 191 to 200 of about 210,409 (218)

Intravenous Lipopolysaccharide Challenge in Healthy Participants Reveals Pharmacodynamic Markers in Blood and Bone Marrow for Early‐Phase Oncology Drug Development

Clinical Pharmacology &Therapeutics, EarlyView.
Demonstrating pharmacological effects in early‐phase oncology clinical trials remains challenging, largely due to the lack of robust pharmacodynamic markers. Lipopolysaccharide (LPS) is used as an immune challenge agent in healthy participants to study drugs for autoimmune conditions.
Igor Radanović, Ingrid Tomljanović, Wieke H. Grievink, Diana R. Pereira, Michelle Osse, Peter van Balen, Maria J. Juachon, Marieke L. de Kam, Lisa Pagan, Manon A.A. Jansen, Matthijs Moerland, Jacobus J. Bosch   +11 more
wiley   +1 more source

Tibialis Cranialis Extrafusal and Intrafusal Myofibers and Muscle Spindle Pathology in Canine Degenerative Myelopathy. [PDF]

Animals (Basel)
Morgan-Jack B, Katz ML, Kick GR, Coates JR.   +3 more
europepmc   +1 more source

Case Report: Spindle cell metaplastic breast carcinoma. [PDF]

Front Oncol
Liu Y, Sun X, Liu J.
europepmc   +1 more source

Dyscoordination of thalamic reticular spindles is associated with social memory deficits in mice and humans with autism spectrum disorder. [PDF]

Nat Commun
Cui D, Wang X, Ai R, Gao F, Sun H, Zhang Y, Lyu Y, Zhang Z, Li W, Qin Y, Guo Y, Liu Y, Zhao N, Wang J, Li S, Wu Y, Zhang S, Wang C, Wang F, Li Y.   +19 more
europepmc   +1 more source

The association between sleep spindles and cognitive performance in euthymic bipolar disorder. [PDF]

Transl Psychiatry
Tröger A, Schneider J, Tsapekos D, Bialonski S, Grieger N, Kalfas M, Frending L, Hartland H, Kuivaniemi-Smith H, Young AH, Ritter P, Strawbridge R.   +11 more
europepmc   +1 more source

Prefoldin function links meiotic chromosome segregation with cellular remodeling and reveals tubulin sensitivity of the meiotic spindle. [PDF]

Sci Adv
Kuwayama N, Styler BS, Stekovic B, Sakharova H, Lareau L, Jovanovic M, Ünal E, Brar GA.   +7 more
europepmc   +1 more source

Propofol-Facilitated Recovery Sleep Modulates Cognitive Function via Slow Oscillation-Spindle Coupling After Acute Sleep Deprivation in Rats. [PDF]

CNS Neurosci Ther
Yang C, Liu H, Wang X, Zhang L, Wang H.
europepmc   +1 more source

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Mechanisms underlying spindle assembly and robustness

Nature Reviews Molecular Cell Biology, 2023
Venecia Valdez, Sophie Dumont, Sabine Petry   +2 more
exaly  

Spindle positioning and its impact on vertebrate tissue architecture and cell fate

Nature Reviews Molecular Cell Biology, 2021
Marina Mapelli, Terry Lechler
exaly