INTERMICROTUBULE BRIDGES IN MITOTIC SPINDLE APPARATUS [PDF]
Peter K. Hepler+2 more
openalex +4 more sources
Spindle birefringence of isolated mitotic apparatus: further evidence for two birefringent spindle components [PDF]
ABSTRACT We studied sea-urchin zygote mitotic apparatus (MA) isolated in hexylene glycol, transferred immediately to a glycerol-dimethylsulphoxide medium, and stored for 2 weeks at room temperature. Treatment with 0·5 M KC1 caused loss of 45% of the birefringence, but microtubules remained intact (as seen electron microscopically in ...
Arthur Forer+2 more
openalex +4 more sources
The centrosome and mitotic spindle apparatus in cancer and senescence [PDF]
Altered cell division is associated with overproliferation and tumorigenesis, however, mitotic aberrations can also trigger antiproliferative responses leading to postmitotic cell cycle exit. Here, we focus on the role of the centrosome and in particular of centrosomal TACC (transforming acidic coiled coil) proteins in tumorigenesis and cellular ...
Stephan Schmidt+13 more
openalex +4 more sources
Phase transition of spindle-associated protein regulate spindle apparatus assembly. [PDF]
Spindle assembly required during mitosis depends on microtubule polymerization. We demonstrate that the evolutionarily conserved low-complexity protein, BuGZ, undergoes phase transition or coacervation to promote assembly of both spindles and their associated components.
Jiang H+6 more
europepmc +5 more sources
The nuclear-mitotic apparatus protein is important in the establishment and maintenance of the bipolar mitotic spindle apparatus. [PDF]
The formation and maintenance of the bipolar mitotic spindle apparatus require a complex and balanced interplay of several mechanisms, including the stabilization and separation of polar microtubules and the action of various microtubule motors. Nonmicrotubule elements are also present throughout the spindle apparatus and have been proposed to provide
Chao Yang, M Snyder
openalex +4 more sources
ASSOCIATION BETWEEN THE SPINDLE APPARATUS AND REOVIRUS [PDF]
Samuel Dales
openalex +4 more sources
Manipulation of the oocyte: possible damage to the spindle apparatus
Oocytes are structured, polarized cells. For high developmental potential, it is essential that the distribution of organelles and molecules, and the function of meiotic spindles remain intact during handling of oocytes in assisted reproduction. Spindles are dynamic cell organelles. Spindle formation depends on activity of motor proteins, energy supply
Ursula Eichenlaub-Ritter+2 more
openalex +4 more sources
Rare Antinuclear Antibody Patterns: Relevance in Routine Laboratory Reporting [PDF]
Introduction: Uncommon patterns on Human Epithelial 2 (Hep 2) substrate during Antinuclear Antibody (ANA) screening by Indirect Immunofluorescence (IIF) microscopy are not routinely reported by many laboratories since their clinical relevance is not well
Vidya Bhakta
doaj +1 more source
Microtubules are the only structural constituent of the spindle apparatus required for induction of cell cleavage [PDF]
Structural constituents of the spindle apparatus essential for cleavage induction remain undefined. Findings from various cell types using different approaches suggest the importance of all structural constituents, including asters, the central spindle, and chromosomes. In this study, we systematically dissected the role of each constituent in cleavage
G. Bradley Alsop, Dahong Zhang
openalex +3 more sources
Evidence for spindle apparatus in somatic nuclei
W. B. Van Winkle
openalex +4 more sources