A spindle-like apparatus guides bacterial chromosome segregation [PDF]
Nature Cell Biology, 2010 Until recently, a dedicated mitotic apparatus that segregates newly replicated chromosomes into daughter cells was believed to be unique to eukaryotic cells. Here we demonstrate that the bacterium Caulobacter crescentus segregates its chromosome using a partitioning (Par) apparatus that has surprising similarities to eukaryotic spindles.
Jerod L. Ptacin +7 more
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Microtubules are the only structural constituent of the spindle apparatus required for induction of cell cleavage [PDF]
The Journal of Cell Biology, 2003 Structural constituents of the spindle apparatus essential for cleavage induction remain undefined. Findings from various cell types using different approaches suggest the importance of all structural constituents, including asters, the central spindle, and chromosomes. In this study, we systematically dissected the role of each constituent in cleavage
G. Bradley Alsop, Dahong Zhang
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eLife, 2023 WDR62 is a spindle pole-associated scaffold protein with pleiotropic functions. Recessive mutations in WDR62 cause structural brain abnormalities and account for the second most common cause of autosomal recessive primary microcephaly (MCPH), indicating ...
Claudia Dell'Amico +9 more
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Autoantibodies to the mitotic spindle apparatus in Mycoplasma pneumoniae disease [PDF]
Infection and Immunity, 1988 Antibodies to the mitotic spindle apparatus (MS) have been detected in only a very few patient sera studied for antinuclear antibodies by routine screening (G. A. McCarty, D. W. Velencia, and M. J. Fritzler, J. Rheumatol. 11:213-218, 1984). We found anti-MS antibodies to be quite common in sera from patients with Mycoplasma pneumoniae, especially in ...
K Lind, Mimi Høier‐Madsen, Allan Wiik
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Microtubule capture by the cleavage apparatus is required for proper spindle positioning in yeast [PDF]
Genes & Development, 2002 Cell division is the result of two major cytoskeletal events: partition of the chromatids by the mitotic spindle and cleavage of the cell by the cytokinetic apparatus. Spatial coordination of these events ensures that each daughter cell inherits a nucleus. Here we show that, in budding yeast, capture and shrinkage of astral microtubules at the bud neck
Justine Kusch +3 more
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INTERMICROTUBULE BRIDGES IN MITOTIC SPINDLE APPARATUS [PDF]
The Journal of Cell Biology, 1970 Peter K. Hepler +2 more
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Spindle assembly defects leading to the formation of a monopolar mitotic apparatus [PDF]
Biology of the Cell, 2008 Mitotic spindle formation in animal cells involves microtubule nucleation from two centrosomes that are positioned at opposite sides of the nucleus. Microtubules are captured by the kinetochores and stabilized. In addition, microtubules can be nucleated independently of the centrosome and stabilized by a gradient of Ran—GTP, surrounding the mitotic ...
Vanessa Tillement +5 more
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Anti-Mitotic Spindle Apparatus Antoantibodies: Prevalence and Disease Association in Chinese Population. [PDF]
J Clin Lab Anal, 2016 BackgroundMitotic spindle apparatus (MSA) antibodies are rare findings with undefined clinical significance in clinical research. We aimed at investigating the prevalence and clinical significance of anti‐MSA antibodies in Chinese population.MethodsBetween 2008 and 2013, a total of 180,180 patients were studied for the presence of anti‐MSA antibodies ...
Xi Q +6 more
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Application of collagen triple helix repeat containing-1 and mitotic spindle apparatus antibody in small cell lung cancer diagnosis. [PDF]
J Clin Lab Anal, 2022 Liu Y +7 more
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ASSOCIATION BETWEEN THE SPINDLE APPARATUS AND REOVIRUS [PDF]
Proceedings of the National Academy of Sciences, 1963 Samuel Dales
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