Anti-Mitotic Spindle Apparatus Antoantibodies: Prevalence and Disease Association in Chinese Population. [PDF]
J Clin Lab Anal, 2016 BackgroundMitotic spindle apparatus (MSA) antibodies are rare findings with undefined clinical significance in clinical research. We aimed at investigating the prevalence and clinical significance of anti‐MSA antibodies in Chinese population.MethodsBetween 2008 and 2013, a total of 180,180 patients were studied for the presence of anti‐MSA antibodies ...
Xi Q +6 more
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Uncommon patterns of antinuclear antibodies recognizing mitotic spindle apparatus antigens and clinical associations. [PDF]
Medicine (Baltimore), 2018 Antinuclear antibodies (ANA) are key biomarkers in the evaluation of rheumatic diseases. The prevalence and clinical significance of uncommon or rare patterns, particularly those directed at the mitotic spindle apparatus (MSA), are not well understood. We aimed to investigate the prevalence and clinical significance of anti-MSA patterns in a Colombian ...
Betancur JF +7 more
europepmc +4 more sources
INTERMICROTUBULE BRIDGES IN MITOTIC SPINDLE APPARATUS [PDF]
The Journal of Cell Biology, 1970 Peter K. Hepler +2 more
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The centrosome and mitotic spindle apparatus in cancer and senescence [PDF]
Cell Cycle, 2010 Altered cell division is associated with overproliferation and tumorigenesis, however, mitotic aberrations can also trigger antiproliferative responses leading to postmitotic cell cycle exit. Here, we focus on the role of the centrosome and in particular of centrosomal TACC (transforming acidic coiled coil) proteins in tumorigenesis and cellular ...
Stephan Schmidt +13 more
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The post-translational modification of NuMA in cancer cells is a new target for cancer eradication [PDF]
Cell Death and DiseaseRecent findings identify a cell-death mechanism in human cancer cells, based on the inhibition of the post-translational modification of NuMA (nuclear mitotic apparatus protein) in cancer cells, which interferes with its protein-binding capacity. NuMA is
Malka Cohen-Armon
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Phase transition of spindle-associated protein regulate spindle apparatus assembly. [PDF]
Cell, 2015 Spindle assembly required during mitosis depends on microtubule polymerization. We demonstrate that the evolutionarily conserved low-complexity protein, BuGZ, undergoes phase transition or coacervation to promote assembly of both spindles and their associated components.
Jiang H +6 more
europepmc +4 more sources
Spindle birefringence of isolated mitotic apparatus: further evidence for two birefringent spindle components [PDF]
Journal of Cell Science, 1976 ABSTRACT We studied sea-urchin zygote mitotic apparatus (MA) isolated in hexylene glycol, transferred immediately to a glycerol-dimethylsulphoxide medium, and stored for 2 weeks at room temperature. Treatment with 0·5 M KC1 caused loss of 45% of the birefringence, but microtubules remained intact (as seen electron microscopically in ...
Arthur Forer +2 more
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Rare Antinuclear Antibody Patterns: Relevance in Routine Laboratory Reporting [PDF]
Journal of Clinical and Diagnostic Research, 2023 Introduction: Uncommon patterns on Human Epithelial 2 (Hep 2) substrate during Antinuclear Antibody (ANA) screening by Indirect Immunofluorescence (IIF) microscopy are not routinely reported by many laboratories since their clinical relevance is not well
Vidya Bhakta
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Autoantibodies to the mitotic spindle apparatus in Mycoplasma pneumoniae disease [PDF]
Infection and Immunity, 1988 Antibodies to the mitotic spindle apparatus (MS) have been detected in only a very few patient sera studied for antinuclear antibodies by routine screening (G. A. McCarty, D. W. Velencia, and M. J. Fritzler, J. Rheumatol. 11:213-218, 1984). We found anti-MS antibodies to be quite common in sera from patients with Mycoplasma pneumoniae, especially in ...
K Lind, Mimi Høier‐Madsen, Allan Wiik
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Nuclear Mitotic Apparatus (NuMA) Interacts with and Regulates Astrin at the Mitotic Spindle [PDF]
Journal of Biological Chemistry, 2016 The large nuclear mitotic apparatus (NuMA) protein is an essential player in mitotic spindle assembly and maintenance. We report here the identification of Astrin, a spindle- and kinetochore-associated protein, as a novel interactor of NuMA. We show that the C-terminal tail of NuMA can directly bind to the C terminus of Astrin and that this interaction
Xiaogang Chu +4 more
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