Results 21 to 30 of about 62,154 (329)
Spindle assembly defects leading to the formation of a monopolar mitotic apparatus [PDF]
Biology of the Cell, 2008 Mitotic spindle formation in animal cells involves microtubule nucleation from two centrosomes that are positioned at opposite sides of the nucleus. Microtubules are captured by the kinetochores and stabilized. In addition, microtubules can be nucleated independently of the centrosome and stabilized by a gradient of Ran—GTP, surrounding the mitotic ...
Vanessa Tillement +5 more
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Genetic Disorders Affecting Tubulin Cytoskeleton [PDF]
Journal of Biomedical & Clinical Research, 2015 The tubulin cytoskeleton is vital for maintenance and dynamics of eukaryotic cells and molecular defects in its components can lead to serious conditions.
Maya Markova +5 more
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A Balance between Nuclear and Cytoplasmic Volumes Controls Spindle Length. [PDF]
PLoS ONE, 2016 Proper assembly of the spindle apparatus is crucially important for faithful chromosome segregation during anaphase. Thanks to the effort over the last decades, we have very detailed information about many events leading to spindle assembly and ...
Lucia Novakova +5 more
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USP11 deubiquitinates RAE1 and plays a key role in bipolar spindle formation. [PDF]
PLoS ONE, 2018 Correct segregation of the mitotic chromosomes into daughter cells is a highly regulated process critical to safeguard genome stability. During M phase the spindle assembly checkpoint (SAC) ensures that all kinetochores are correctly attached before its ...
Anna Stockum +2 more
doaj +1 more source
Cell Division, 2021 Background Ral family is a member of Ras-like GTPase superfamily, which includes RalA and RalB. RalA/B play important roles in many cell biological functions, including cytoskeleton dynamics, cell division, membrane transport, gene expression and signal ...
Ming-Hong Sun +7 more
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Ontogenetic Alteration of the Spindle Apparatus: Possible Relation to Chromosome Pairing
Caryologia, 1973 SUMMARYAs the monocot Ornithogalum virens matures from seed germination to flowering there is a progressive reduction in the diameter of mitotic spindle apparatuses at the metaphase plate, and poles become more distinct. Apparently one result of this constriction of the spindle is a closer association of chromosomes on the metaphase plate which could ...
Stephen M. Stack +2 more
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The association between muscle architecture and muscle spindle abundance
Scientific Reports, 2023 Across the human body, skeletal muscles have a broad range of biomechanical roles that employ complex proprioceptive control strategies to successfully execute a desired movement.
Roger W. P. Kissane +3 more
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A spindle-like apparatus guides bacterial chromosome segregation [PDF]
Nature Cell Biology, 2010 Until recently, a dedicated mitotic apparatus that segregates newly replicated chromosomes into daughter cells was believed to be unique to eukaryotic cells. Here we demonstrate that the bacterium Caulobacter crescentus segregates its chromosome using a partitioning (Par) apparatus that has surprising similarities to eukaryotic spindles.
Jerod L, Ptacin +7 more
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Mechanisms of spindle bipolarity establishment in acentrosomal human cells
Molecular & Cellular Oncology, 2020 Centrosomes are not absolutely essential for cell division; acentrosomal bipolar spindles can be established in oocytes and centrosome-eliminated somatic cells.
Kaho Hashimoto +2 more
doaj +1 more source
PLoS ONE, 2012 The mitotic spindle is an essential molecular machine involved in cell division, whose composition has been studied extensively by detailed cellular biology, high-throughput proteomics, and RNA interference experiments.
Ana M Rojas +20 more
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