Results 21 to 30 of about 59,120 (328)
Microtubule capture by the cleavage apparatus is required for proper spindle positioning in yeast [PDF]
Genes & Development, 2002 Cell division is the result of two major cytoskeletal events: partition of the chromatids by the mitotic spindle and cleavage of the cell by the cytokinetic apparatus. Spatial coordination of these events ensures that each daughter cell inherits a nucleus. Here we show that, in budding yeast, capture and shrinkage of astral microtubules at the bud neck
Justine Kusch +3 more
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Nuclear Mitotic Apparatus (NuMA) Interacts with and Regulates Astrin at the Mitotic Spindle [PDF]
Journal of Biological Chemistry, 2016 The large nuclear mitotic apparatus (NuMA) protein is an essential player in mitotic spindle assembly and maintenance. We report here the identification of Astrin, a spindle- and kinetochore-associated protein, as a novel interactor of NuMA. We show that the C-terminal tail of NuMA can directly bind to the C terminus of Astrin and that this interaction
Xiaogang Chu +4 more
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Autoantibodies to the mitotic spindle apparatus in Mycoplasma pneumoniae disease [PDF]
Infection and Immunity, 1988 Antibodies to the mitotic spindle apparatus (MS) have been detected in only a very few patient sera studied for antinuclear antibodies by routine screening (G. A. McCarty, D. W. Velencia, and M. J. Fritzler, J. Rheumatol. 11:213-218, 1984). We found anti-MS antibodies to be quite common in sera from patients with Mycoplasma pneumoniae, especially in ...
K Lind, Mimi Høier‐Madsen, Allan Wiik
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Genetic Disorders Affecting Tubulin Cytoskeleton [PDF]
Journal of Biomedical & Clinical Research, 2015 The tubulin cytoskeleton is vital for maintenance and dynamics of eukaryotic cells and molecular defects in its components can lead to serious conditions.
Maya Markova +5 more
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Spindle assembly defects leading to the formation of a monopolar mitotic apparatus [PDF]
Biology of the Cell, 2008 Mitotic spindle formation in animal cells involves microtubule nucleation from two centrosomes that are positioned at opposite sides of the nucleus. Microtubules are captured by the kinetochores and stabilized. In addition, microtubules can be nucleated independently of the centrosome and stabilized by a gradient of Ran—GTP, surrounding the mitotic ...
Vanessa Tillement +5 more
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A spindle-like apparatus guides bacterial chromosome segregation [PDF]
Nature Cell Biology, 2010 Until recently, a dedicated mitotic apparatus that segregates newly replicated chromosomes into daughter cells was believed to be unique to eukaryotic cells. Here we demonstrate that the bacterium Caulobacter crescentus segregates its chromosome using a partitioning (Par) apparatus that has surprising similarities to eukaryotic spindles.
Jerod L. Ptacin +7 more
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A Balance between Nuclear and Cytoplasmic Volumes Controls Spindle Length. [PDF]
PLoS ONE, 2016 Proper assembly of the spindle apparatus is crucially important for faithful chromosome segregation during anaphase. Thanks to the effort over the last decades, we have very detailed information about many events leading to spindle assembly and ...
Lucia Novakova +5 more
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USP11 deubiquitinates RAE1 and plays a key role in bipolar spindle formation. [PDF]
PLoS ONE, 2018 Correct segregation of the mitotic chromosomes into daughter cells is a highly regulated process critical to safeguard genome stability. During M phase the spindle assembly checkpoint (SAC) ensures that all kinetochores are correctly attached before its ...
Anna Stockum +2 more
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Cell Division, 2021 Background Ral family is a member of Ras-like GTPase superfamily, which includes RalA and RalB. RalA/B play important roles in many cell biological functions, including cytoskeleton dynamics, cell division, membrane transport, gene expression and signal ...
Ming-Hong Sun +7 more
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Mechanisms of spindle bipolarity establishment in acentrosomal human cells
Molecular & Cellular Oncology, 2020 Centrosomes are not absolutely essential for cell division; acentrosomal bipolar spindles can be established in oocytes and centrosome-eliminated somatic cells.
Kaho Hashimoto +2 more
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