The Spindle Assembly Checkpoint [PDF]
, 2012 During mitosis and meiosis, the spindle assembly checkpoint acts to maintain genome stability by delaying cell division until accurate chromosome segregation can be guaranteed.
Lara-Gonzalez, Pablo +2 more
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A regulatory effect of INMAP on centromere proteins: antisense INMAP induces CENP-B variation and centromeric halo. [PDF]
PLoS ONE, 2014 CENP-B is a highly conserved protein that facilitates the assembly of specific centromere structures both in interphase nuclei and on mitotic chromosomes. INMAP is a conserved protein that localizes at nucleus in interphase cells and at mitotic apparatus
Tan Tan +4 more
doaj +1 more source
Disjunction of conjoined twins: Cdk1, Cdh1 and separation of centrosomes
Cell Division, 2006 Accurate transmission of chromosomes from parent to progeny cell requires assembly of a bipolar spindle. Centrosomes (spindle pole body in yeast) are critical for the biogenesis of this complex mitotic apparatus since they confer bipolarity on the ...
Surana Uttam, Crasta Karen
doaj +1 more source
Dominant-Negative Effects of Adult-Onset Huntingtin Mutations Alter the Division of Human Embryonic Stem Cells-Derived Neural Cells. [PDF]
PLoS ONE, 2016 Mutations of the huntingtin protein (HTT) gene underlie both adult-onset and juvenile forms of Huntington's disease (HD). HTT modulates mitotic spindle orientation and cell fate in mouse cortical progenitors from the ventricular zone.
Carla Lopes +7 more
doaj +1 more source
A bacteriophage tubulin harnesses dynamic instability to center DNA in infected cells. [PDF]
, 2014 Dynamic instability, polarity, and spatiotemporal organization are hallmarks of the microtubule cytoskeleton that allow formation of complex structures such as the eukaryotic spindle. No similar structure has been identified in prokaryotes.
Agard, David A +6 more
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Two major autoantigen—Antibody systems of the mitotic spindle apparatus [PDF]
Arthritis & Rheumatism, 1996 AbstractObjective. To characterize human autoantigen‐antibody systems related to the mitotic poles and spindles.Methods. Thirty‐seven human sera with autoantibodies staining mitotic poles and spindles in indirect immunofluorescence (IIF) studies were further characterized by immunofluorescence on mitotic cells and by immunoblotting and ...
Luis Eduardo Coelho Andrade +3 more
openaire +3 more sources
Evolutionary cell biology of chromosome segregation: insights from trypanosomes [PDF]
Open Biology, 2013 Faithful transmission of genetic material is essential for the survival of all organisms. Eukaryotic chromosome segregation is driven by the kinetochore that assembles onto centromeric DNA to capture spindle microtubules and govern the movement of ...
Bungo Akiyoshi, Keith Gull
doaj +1 more source
Frontiers in Marine Science, 2021 Fertilized Zhikong scallop (Chlamys farreri) eggs were treated with cytochalasin B (CB 0.5 mg/L) at 14–15 min postfertilization to inhibit first polar body formation.
Yongren Li +3 more
doaj +1 more source
Generation and Characterization of a Tissue-Specific Centrosome Indicator Mouse Line. [PDF]
, 2016 Centrosomes are major microtubule organizing centers (MTOCs) that play an important role in chromosome segregation during cell division. Centrosomes provide a stable anchor for microtubules, constituting the centers of the spindle poles in mitotic cells,
Chen, Ju +2 more
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Microtubule and Actin Cytoskeletal Dynamics in Male Meiotic Cells of Drosophila melanogaster
Cells, 2022 Drosophila dividing spermatocytes offer a highly suitable cell system in which to investigate the coordinated reorganization of microtubule and actin cytoskeleton systems during cell division of animal cells.
Anna Frappaolo +2 more
doaj +1 more source