Results 91 to 100 of about 50,149 (285)

High Sugar Induced RCC2 Lactylation Drives Breast Cancer Tumorigenicity Through Upregulating MAD2L1

Advanced Science, EarlyView.
This study finds that KAT2A mediates the lactylation modification of the non‐histone protein RCC2 at K124, facilitating the recruitment of free SERBP1 and aiding in the formation of the initial SERBP1‐MAD2L1 complex. SERBP1 enhances the stability of MAD2L1 mRNA and promotes cellular proliferation.
Bowen Zheng, Yunhao Pan, Fengyuan Qian, Diya Liu, Danrong Ye, Bolin Yu, Seng Zhong, Wenfang Zheng, Xuehui Wang, Baian Zhou, Yuying Wang, Lin Fang   +11 more
wiley   +1 more source

A role for the spindle assembly checkpoint in the DNA damage response [PDF]

Current Genetics, 2016
Spontaneous DNA damage poses a continuous threat to genomic integrity. If unchecked, genotoxic insults result in genomic instability, a hallmark of cancer cells. In eukaryotic cells a DNA Damage Response (DDR) detects and responds to genotoxic stress, acting as an anti-cancer barrier in humans.
Palou, Roger, Palou Marin, Gloria, Garcia Quintana, David   +2 more
openaire   +5 more sources

Kre28–Spc105 interaction is essential for Spc105 loading at the kinetochore

Open Biology, 2022
Kinetochore (KTs) are macromolecular protein assemblies that attach sister chromatids to spindle microtubules (MTs) and mediate accurate chromosome segregation during mitosis.
Babhrubahan Roy, Janice Sim, Simon J. Y. Han, Ajit P. Joglekar   +3 more
doaj   +1 more source

Meiotic spindle assembly checkpoint and aneuploidy in males versus females

Cellular and Molecular Life Sciences, 2018
The production of gametes (sperm and eggs in mammals) involves two sequential cell divisions, meiosis I and meiosis II. In meiosis I, homologous chromosomes segregate to different daughter cells, and meiosis II resembles mitotic divisions in that sister ...
Simon I. R. Lane, L. Kauppi
semanticscholar   +1 more source

The Hypoxia‐Associated High‐Risk Cell Subpopulation Distinctly Enhances the Progression of Glioma

Advanced Science, EarlyView.
This study suggests the potential roles of a novel hypoxia‐associated CDC20+KIF20A+PTTG1+ cell subpopulation in glioma progression. This high‐risk glioma cell subpopulation is therapeutically vulnerable to glioma progression and may play important roles in glioma standard‐of‐care therapeutic resistance.
Quan Wan, Xuechao Wu, Jinxu Zhou, Weiqi Wu, Yuanliang Cao, Cuiping Sun, Zheng Li, Zhicheng Gong, Hong Tang, Qilin Li, Junsheng Chu, Qing Wang, Kaisa Cui, Xiaojie Lu   +13 more
wiley   +1 more source

The spindle assembly checkpoint gets a complex [PDF]

The Journal of Cell Biology, 2001
![Graphic][1] MCC turns off the APC better than Mad2 alone. Once a cell has successfully replicated its DNA, it must correctly segregate its chromosomes, a process guarded by the spindle assembly checkpoint. Sudakin et al.
openaire   +2 more sources

Spindle assembly checkpoint and its regulators in meiosis [PDF]

Human Reproduction Update, 2011
BACKGROUND Meiosis is a unique form of cell division in which cells divide twice but DNA is duplicated only once. Errors in chromosome segregation during meiosis will result in aneuploidy, followed by loss of the conceptus during pregnancy or birth defects. During mitosis, cells utilize a mechanism called the spindle assembly checkpoint (SAC) to ensure
Shao-Chen Sun, Nam-Hyung Kim
openaire   +3 more sources

Axin-1 Regulates Meiotic Spindle Organization in Mouse Oocytes. [PDF]

PLoS ONE, 2016
Axin-1, a negative regulator of Wnt signaling, is a versatile scaffold protein involved in centrosome separation and spindle assembly in mitosis, but its function in mammalian oogenesis remains unknown.
Xiao-Qin He, Yue-Qiang Song, Rui Liu, Yu Liu, Fei Zhang, Zhen Zhang, Yu-Ting Shen, Lin Xu, Ming-Huang Chen, Ya-Long Wang, Bai-Hui Xu, Xiang-Jun Yang, Hai-Long Wang   +12 more
doaj   +1 more source

Identification and Biological Evaluation of a Novel CLK4 Inhibitor Targeting Alternative Splicing in Pancreatic Cancer Using Structure‐Based Virtual Screening

Advanced Science, EarlyView.
Pancreatic cancer is a highly aggressive malignancy with limited treatment options. CLK4 regulates alternative splicing, contributing to cancer progression. This study establishes a computational model to identify CLK4 inhibitors, leading to compound 150441 (IC50: 21.4 nm).
Chun‐Lin Yang, Yi‐Wen Wu, Huang‐Ju Tu, Yun‐Hsuan Yeh, Tony Eight Lin, Tzu‐Ying Sung, Mu‐Chun Li, Shih‐Chung Yen, Jui‐Hua Hsieh, Ming‐Chin Yu, Sen‐Yung Hsieh, Hsing‐Pang Hsieh, Shiow‐Lin Pan, Kai‐Cheng Hsu   +13 more
wiley   +1 more source

DNA damage activates the SAC in an ATM/ATR-dependent manner, independently of the kinetochore. [PDF]

PLoS Genetics, 2008
The DNA damage checkpoint and the spindle assembly checkpoint (SAC) are two important regulatory mechanisms that respond to different lesions. The DNA damage checkpoint detects DNA damage, initiates protein kinase cascades, and inhibits the cell cycle ...
Eun Mi Kim, Daniel J Burke
doaj   +1 more source