Results 31 to 40 of about 50,149 (285)

How germline genes promote malignancy in cancer cells

BioEssays, Volume 45, Issue 1, January 2023., 2023
We hypothesize that activation of a “germline program” promotes oncogenesis. Expression of otherwise germline specific genes may result in pseudomeiotic activity, thereby promoting oncogenesis through genomic instability. Other processes that are differentially regulated in the germline, such as migration and epigenetic – and metabolic plasticity, may ...
Jan Willem Bruggeman, Jan Koster, Ans M. M. van Pelt, Dave Speijer, Geert Hamer   +4 more
wiley   +1 more source

Yeast Kinesin-5 Motor Protein CIN8 Promotes Accurate Chromosome Segregation

Cells, 2022
Accurate chromosome segregation depends on bipolar chromosome–microtubule attachment and tension generation on chromosomes. Incorrect chromosome attachment results in chromosome missegregation, which contributes to genome instability.
Delaney Sherwin, Abigail Huetteman, Yanchang Wang   +2 more
doaj   +1 more source

Alcohol extracts of Chinese bayberry branch induce S‐phase arrest and apoptosis in HepG2 cells

Food Science &Nutrition, Volume 11, Issue 1, Page 493-503, January 2023., 2023
The alcohol extracts of Chinese bayberry Myrica rubra branches (MRBE) effectively inhibited the proliferation of HepG2 cells by inducing cell cycle arrest in S phase and promoting apoptosis, with this arrest potentially mediated by the activation of p21–Cyclin–CDK (cyclin‐dependent kinase) complex signaling pathways.
Yuanyuan Zheng, Zheping Yu, Yougui Li, Shi Zhong, Yuqing Sun, Li Sun, Xiliang Zheng, Xingjiang Qi, Shuwen Zhang   +8 more
wiley   +1 more source

A YAP/FOXM1 axis mediates EMT-associated EGFR inhibitor resistance and increased expression of spindle assembly checkpoint components

Science Translational Medicine, 2020
YAP and FOXM1 are mediators of EGFR inhibitor resistance, and spindle proteins are therapeutic targets for this multidrug-resistant phenotype. Path of least resistance Drugs that inhibit the epidermal growth factor (EGFR) are used in a number of cancer ...
M. Nilsson, Huiying Sun, J. Robichaux, Matthias Pfeifer, U. McDermott, Jon Travers, L. Diao, Y. Xi, P. Tong, Li Shen, Mia Hofstad, Masanori Kawakami, X. Le, Xi Liu, Youhong Fan, A. Poteete, Limei Hu, M. Negrão, H. Tran, E. Dmitrovsky, D. Peng, D. Gibbons, Jing Wang, J. Heymach   +23 more
semanticscholar   +1 more source

Inactivation of RB1, CDKN2A, and TP53 have distinct effects on genomic stability at side‐by‐side comparison in karyotypically normal cells

Genes, Chromosomes and Cancer, Volume 62, Issue 2, Page 93-100, February 2023., 2023
Abstract Chromosomal instability is a common feature in malignant tumors. Previous studies have indicated that inactivation of the classical tumor suppressor genes RB1, CDKN2A, and TP53 may contribute to chromosomal aberrations in cancer by disrupting different aspects of the cell cycle and DNA damage checkpoint machinery.
Natalie Andersson, Karim H. Saba, Linda Magnusson, Jenny Nilsson, Jenny Karlsson, Karolin H. Nord, David Gisselsson   +6 more
wiley   +1 more source

Noise resistance in the spindle assembly checkpoint [PDF]

Molecular Systems Biology, 2006
Genetically identical cells vary in the amount of expressed proteins even when growing under the same conditions. It is not yet clear how cellular information processing copes with such stochastic fluctuations in protein levels. Here we examine the capacity of the spindle assembly checkpoint to buffer temporal fluctuations in the expression of Cdc20, a
Eshel Ben-Jacob, Andreas Doncic, Andreas Doncic, Naama Barkai   +3 more
openaire   +3 more sources

Dynein Light Intermediate Chain 2 Facilitates the Metaphase to Anaphase Transition by Inactivating the Spindle Assembly Checkpoint. [PDF]

PLoS ONE, 2016
The multi-functional molecular motor cytoplasmic dynein performs diverse essential roles during mitosis. The mechanistic importance of the dynein Light Intermediate Chain homologs, LIC1 and LIC2 is unappreciated, especially in the context of mitosis ...
Sagar P Mahale, Amit Sharma, Sivaram V S Mylavarapu   +2 more
doaj   +1 more source

Membrane shape deformation induced by curvature-inducing proteins consisting of chiral crescent binding and intrinsically disordered domains [PDF]

J. Chem. Phys. 157, 034901 (2022), 2022
Curvature-inducing proteins containing a Bin/Amphiphysin/Rvs domain often have intrinsically disordered domains. Recent experiments have shown that these disordered chains enhance curvature sensing and generation. Here, we report on the modification of protein-membrane interactions by disordered chains using meshless membrane simulations.
arxiv   +1 more source

Spindle assembly checkpoint, aneuploidy and tumorigenesis [PDF]

Cell Cycle, 2009
Faithfully distributing chromosomes into two daughter cells in mitosis is essential for the maintenance of the integrity of the genome genome. The fidelity is achieved through a number of cellular processes among which is the spindle assembly checkpoint (SAC), an elaborate molecular pathway that monitors the attachment of microtubules to kinetochores ...
Min Li, Pumin Zhang
openaire   +3 more sources

Mitotic slippage is determined by p31comet and the weakening of the spindle-assembly checkpoint

Oncogene, 2020
Mitotic slippage involves cells exiting mitosis without proper chromosome segregation. Although degradation of cyclin B1 during prolonged mitotic arrest is believed to trigger mitotic slippage, its upstream regulation remains obscure.
Tsun Ming Lok, Yang Wang, Wendy Kaichun Xu, S. Xie, H. Ma, R. Poon   +5 more
semanticscholar   +1 more source