Results 61 to 70 of about 50,149 (285)
Kinetic framework of spindle assembly checkpoint signalling [PDF]
Nature Cell Biology, 2013 The mitotic spindle assembly checkpoint (SAC) delays anaphase onset until all chromosomes have attached to both spindle poles. Here, we investigated SAC signalling kinetics in response to acute detachment of individual chromosomes using laser microsurgery. Most detached chromosomes delayed anaphase until they had realigned to the metaphase plate.
Amalie E. Dick +2 more
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TRIP13 is a protein-remodeling AAA+ ATPase that catalyzes MAD2 conformation switching
eLife, 2015 The AAA+ family ATPase TRIP13 is a key regulator of meiotic recombination and the spindle assembly checkpoint, acting on signaling proteins of the conserved HORMA domain family.
Qiaozhen Ye +5 more
doaj +1 more source
A quantitative systems view of the spindle assembly checkpoint [PDF]
The EMBO Journal, 2009 The idle assembly checkpoint acts to delay chromosome segregation until all duplicated sister chromatids are captured by the mitotic spindle. This pathway ensures that each daughter cell receives a complete copy of the genome. The high fidelity and robustness of this process have made it a subject of intense study in both the experimental and ...
Ciliberto, Andrea, Shah, Jagesh V.
openaire +4 more sources
Frontiers in Plant Science, 2016 The classic maize mutant divergent spindle-1 (dv1) causes failures in meiotic spindle assembly and a decrease in pollen viability. By analyzing two independent dv1 alleles we demonstrate that this phenotype is caused by mutations in a member of the ...
David M Higgins +3 more
doaj +1 more source
Orchestration of the spindle assembly checkpoint by CDK1‐cyclin B1
FEBS Letters, 2019 In mitosis, the spindle assembly checkpoint (SAC) monitors the formation of microtubule‐kinetochore attachments during capture of chromosomes by the mitotic spindle. Spindle assembly is complete once there are no longer any unattached kinetochores. Here,
D. Hayward +2 more
semanticscholar +1 more source
Precocious centriole disengagement and centrosome fragmentation induced by mitotic delay
Nature Communications, 2017 The spindle assembly checkpoint delays mitotic progression until sister chromatids are bi-oriented. Here the authors show that moderate delays in mitotic progression induce centrosome fragmentation and centriole disengagement and that spindle bipolarity ...
Menuka Karki +2 more
doaj +1 more source
Generation of stable overlaps between antiparallel filaments [PDF]
Phys. Rev. Lett. 115, 118103 (2015), 2015 During cell division, sister chromatids are segregated by the mitotic spindle, a bipolar assembly of interdigitating antiparallel polar filaments called microtubules. Establishing a stable overlap region is essential for maintenance of bipolarity, but the underlying mechanisms are poorly understood. Using a particle-based stochastic model, we find that
arxiv +1 more source
Regulation of mitotic progression by the spindle assembly checkpoint [PDF]
Molecular & Cellular Oncology, 2015 Equal segregation of sister chromatids during mitosis requires that pairs of kinetochores establish proper attachment to microtubules emanating from opposite poles of the mitotic spindle. The spindle assembly checkpoint (SAC) protects against errors in segregation by delaying sister separation in response to improper kinetochore-microtubule ...
Lischetti, Tiziana, Nilsson, Jakob
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A Mathematical Framework for Kinetochore-Driven Activation Feedback in the Mitotic Checkpoint [PDF]
, 2017 Proliferating cells properly divide into their daughter cells through a process that is mediated by kinetochores, protein-complexes that assemble at the centromere of each sister chromatid. Each kinetochore has to establish a tight bipolar attachment to the spindle apparatus before sister-chromatid separation is initiated.
arxiv +1 more source
Cells, 2019 The present study aimed to investigate the effect of melatonin (MT) supplementation on in vitro maturation of vitrified mouse germinal vesicle (GV) oocytes.
Z. Wu +11 more
semanticscholar +1 more source