Results 111 to 120 of about 727 (157)

Transformation of the cyclohexane ring to the cyclopentane fragment of biologically active compounds. [PDF]

Beilstein J Org Chem
Akhmetdinova N, Biktagirov I, Faizullina LK.   +2 more
europepmc   +1 more source

Quantitative structure-activity relationship and ADME prediction studies on series of spirooxindoles derivatives for anti-cancer activity against colon cancer cell line HCT-116. [PDF]

Heliyon
Kaur S, Kaur J, Zarger BA, Islam N, Mir N.   +4 more
europepmc   +1 more source

MDM2 as a therapeutic target in advanced biliary tract cancers. [PDF]

Oncologist
Spencer KR, King GG.
europepmc   +1 more source

Recent advances in microwave-assisted multicomponent synthesis of spiro heterocycles. [PDF]

RSC Adv
Javahershenas R, Makarem A, Klika KD.
europepmc   +1 more source

Editorial: Five-membered ring heterocyclic compounds as anticancer drug candidates. [PDF]

Front Chem
Mermer A, Orhan İE, Ye G, Kumar NA, Danac R.   +4 more
europepmc   +1 more source

Ultrafast and efficient continuous flow organic synthesis with a modified extruder-grinder system. [PDF]

Sci Rep
Hosseinchi Qareaghaj O, Ghaffarzadeh M, Azizi N.   +2 more
europepmc   +1 more source

Dynamic radical recombination enabling stereodivergent construction of spirocycles with nonadjacent stereocenters. [PDF]

Nat Commun
Sun Z, Huang J, Ren J, Zhao K, Chen X, Liang J, Li Y, Peng F, Jin Y, Ou Y, Xu J, Zhang Z, Shao Z.   +12 more
europepmc   +1 more source

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Enantioselective Construction of Spirooxindole-Fused Cyclopentanes

The Journal of Organic Chemistry, 2021
The present study reports an asymmetric organocatalytic cascade reaction of oxindole derivates with α,β-unsaturated aldehydes efficiently catalyzed by simple chiral secondary amine. Spirooxindole-fused cyclopentanes were produced in excellent isolated yields (up to 98%) with excellent enantiopurities (up to 99% ee) and moderate to high ...
Vojtěch Dočekal, Andrea Vopálenská, Pavel Měrka, Klára Konečná, Ondřej Jand’ourek, Milan Pour, Ivana Císařová, Jan Veselý   +7 more
openaire   +2 more sources

A New Route to Spirooxindoles

Organic Letters, 2000
[reaction: see text]Reaction of indole amides 5 with tributylstannane gave spiroindolenines 9 which are readily converted into spiropyrrolidinyloxindoles. This tricyclic system is found in a number of interesting natural products.
S T, Hilton, T C, Ho, G, Pljevaljcic, K, Jones   +3 more
openaire   +2 more sources

Spirooxindoles as Potential Pharmacophores

Mini-Reviews in Medicinal Chemistry, 2017
The spiroindole heterocyclic scaffold is found in many natural products and has been identified as an important bioactive agent. Over the past few decades, various spiroindole-containing compounds have been reported to possess biological properties and hence found in the structure of many synthetic pharmaceuticals.
Siva S, Panda, Rachel A, Jones, Praveen, Bachawala, Prabhu P, Mohapatra   +3 more
openaire   +3 more sources