Results 1 to 10 of about 58,017 (329)
Direct and indirect effects of spliceosome disruption compromise gene regulation by nonsense-mediated mRNA decay [PDF]
RNA BiologyPre-mRNA splicing, carried out in the nucleus by a large ribonucleoprotein machine known as the spliceosome, is functionally and physically coupled to the mRNA surveillance pathway in the cytoplasm called nonsense-mediated mRNA decay (NMD).
Caleb M. Embree +3 more
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Molecular basis for the activation of human spliceosome
Nature CommunicationsThe spliceosome executes pre-mRNA splicing through four sequential stages: assembly, activation, catalysis, and disassembly. Activation of the spliceosome, namely remodeling of the pre-catalytic spliceosome (B complex) into the activated spliceosome ...
Xiechao Zhan, Yichen Lu, Yigong Shi
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Spliceosome assembly and regulation: insights from analysis of highly reduced spliceosomes
RNA, 2023 Premessenger RNA splicing is catalyzed by the spliceosome, a multimegadalton RNA–protein complex that assembles in a highly regulated process on each intronic substrate.
C. Black +5 more
semanticscholar +3 more sources
Microinflammation-Driven Gene Expression Dynamics in the Pathogenesis of Metabolic Disorders and Cancer [PDF]
BiologyMicroinflammation serves as a central mechanism linking metabolic diseases and cancer. This study integrates gene expression profiles from irritable bowel syndrome (IBS), obesity, type 2 diabetes (T2D), colorectal cancer (CRC), renal cell carcinoma (RCC),
Marian Elisa Gabrielle T. Cadungog +1 more
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Modeling craniofacial spliceosomopathies: a pathway toward deciphering disease mechanisms [PDF]
Frontiers in Cell and Developmental BiologyCraniofacial spliceosomopathies are syndromes resulting from mutations in components of the spliceosome, presenting with facial dysostosis in combination with other phenotypes.
Casey Griffin
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iScience, 2023 Summary: Ribonucleoprotein (RNP) condensates are crucial for controlling RNA metabolism and splicing events in animal cells. We used spatial proteomics and transcriptomic to elucidate RNP interaction networks at the centrosome, the main microtubule ...
Luigi Cerulo +11 more
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Cell Reports, 2022 Summary: The spliceosome is a large ribonucleoprotein complex responsible for pre-mRNA splicing and genome stability maintenance. Disruption of the spliceosome activity may lead to developmental disorders and tumorigenesis.
Gui-Xin Ruan +8 more
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Non-canonical functions of spliceosome components in cancer progression
Cell Death and Disease, 2023 Dysregulation of pre-mRNA splicing is a common hallmark of cancer cells and it is associated with altered expression, localization, and mutations of the components of the splicing machinery.
O. Ivanova +6 more
semanticscholar +1 more source
psiCLIP reveals dynamic RNA binding by DEAH-box helicases before and after exon ligation
Nature Communications, 2021 ATP-dependent helicases remodel the spliceosome and proofread splice site recognition. A new method – Purified Spliceosome iCLIP (psiCLIP) – probes protein-RNA interactions in defined spliceosome complexes to reveal how the helicases Prp16 and Prp22 ...
Lisa M. Strittmatter +9 more
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Emerging roles of spliceosome in cancer and immunity
Protein & Cell, 2021 Precursor messenger RNA (pre-mRNA) splicing is catalyzed by an intricate ribonucleoprotein complex called the spliceosome. Although the spliceosome is considered to be general cell “housekeeping” machinery, mutations in core components of the spliceosome
Hui Yang, B. Beutler, Duanwu Zhang
semanticscholar +1 more source