Results 121 to 130 of about 17,120 (319)
Identification of small molecule inhibitors of pre-mRNA splicing [PDF]
, 2014 Background: There is a need for new small molecule pre-mRNA splicing inhibitors as biotools. Results: High throughput screening resulted in the identification of small molecule splicing inhibitors that are active in vitro and in cells.
Gray, David +8 more
core +2 more sources
Advanced Genetics, Volume 6, Issue 1, March 2025.This study comprehensively evaluated the differential effect of clonal hematopoiesis (CH) mutations on the risk of various stroke subtypes and functional recovery. It shows that TET2 is associated with small vessel stroke possibly via a pro‐inflammatory pathway. Abstract Recent observational studies have found an association between Clonal Hematopoesis
Shuyang Lin, Yang E. Li, Yan Wang
wiley +1 more source
Cell Reports, 2023 Summary: Aspartyl-tRNA synthetase 2 (Dars2) is involved in the regulation of mitochondrial protein synthesis and tissue-specific mitochondrial unfolded protein response (UPRmt).
Xuan Gu +9 more
doaj
CellTree: an R/bioconductor package to infer the hierarchical structure of cell populations from single-cell RNA-seq data [PDF]
, 2016 GO BP Terms for myoblast data. Full table of enriched GO BP terms for each topic in myoblast data.
David A. duVerle +4 more
core +10 more sources
Microbiota humanization drives human‐like metabolic and immune transcriptomic shifts in pigs
iMetaOmics, EarlyView.This study successfully established gut microbiota‐humanized pigs, achieved human‐like remodeling of the serum metabolome, and uncovered transcriptional alterations in immune cell subsets. These findings advance our understanding of how human gastrointestinal microorganisms affect host metabolism and the immune function in a porcine model.
Zhaoqi Zhang +9 more
wiley +1 more source
In Vitro Studies of the Prp9·Prp11·Prp21 Complex Indicate a Pathway for U2 Small Nuclear Ribonucleoprotein Activation [PDF]
, 1996 Pre-mRNA splicing takes place on a large ribonucleoprotein particle, the spliceosome which contains the five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6. In Saccharomyces cerevisiae the mRNA splicing factors, Prp9, Prp11, and Prp21,
Abelson, John +2 more
core +1 more source
Proteomic Insight Into Alzheimer's Disease Pathogenesis Pathways
PROTEOMICS, EarlyView.ABSTRACT Alzheimer's disease (AD) is a leading cause of dementia, but the pathogenesis mechanism is still elusive. Advances in proteomics have uncovered key molecular mechanisms underlying AD, revealing a complex network of dysregulated pathways, including amyloid metabolism, tau pathology, apolipoprotein E (APOE), protein degradation ...
Taekyung Ryu +3 more
wiley +1 more source
Quantifying literature citations, index terms, and Gene Ontology annotations in the Saccharomyces Genome Database to assess results-set clustering utility [PDF]
, 2006 A set of 37,325 unique literature citations was identified from 120,078 literature-based annotations in the Saccharomyces Genome Database (SGD). The citations, gene products, and related Gene Ontology (GO) annotations were analyzed to quantify unique ...
MacMullen, W. John
core
PRP4: a protein of the yeast U4/U6 small nuclear ribonucleoprotein particle [PDF]
, 1989 The Saccharomyces cerevisiae prp mutants (prp2 through prp11) are known to be defective in pre-mRNA splicing at nonpermissive temperatures. We have sequenced the PRP4 gene and shown that it encodes a 52-kilodalton protein.
Abelson, John N., Banroques, Josette
core +1 more source
PROTEOMICS, EarlyView.ABSTRACT Multiple myeloma (MM) remains incurable; gaps in our understanding of MM molecular pathogenesis and drugs’ resistance mechanisms are involved in the failure of therapies. This study aims to identify proteins significantly impacting MM patients’ response to commonly used therapeutic regimens.
Foteini Paradeisi +14 more
wiley +1 more source