Quantifying literature citations, index terms, and Gene Ontology annotations in the Saccharomyces Genome Database to assess results-set clustering utility [PDF]
, 2006 A set of 37,325 unique literature citations was identified from 120,078 literature-based annotations in the Saccharomyces Genome Database (SGD). The citations, gene products, and related Gene Ontology (GO) annotations were analyzed to quantify unique ...
MacMullen, W. John
core
Membraneless Organelles and Phase Separation in Tumours: Mechanisms and Prospects
Cell Proliferation, EarlyView.The Salient and Novel Findings: This article summarises the latest research advancements in phase separation within tumours, with a particular focus on the role and molecular mechanisms of liquid–liquid phase separation (LLPS) in tumour progression.
Hao Yang +3 more
wiley +1 more source
A U1 snRNA:pre-mRNA base pairing interaction is required early in yeast spliceosome assembly but does not uniquely define the 5′ cleavage site. [PDF]
, 1988 Bertrand Séraphin +2 more
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Cell Proliferation, EarlyView.GLS1‐mediated glutaminolysis supports GSH synthesis in cancer cells. GLS1 KO increases ROS, downregulates GPX4, and upregulates GPX1, making cells more sensitive to ferroptosis. Combining GLS1 or GPX1 inhibitors with a GPX4 inhibitor synergistically suppresses cancer growth.
Changsen Bai +13 more
wiley +1 more source
Frontiers in Molecular Neuroscience, 2017 While the cytoplasmic function of microRNA (miRNA) as post-transcriptional regulators of mRNA has been the subject of significant research effort, their activity in the nucleus is less well characterized.
Belinda J. Goldie +11 more
doaj +1 more source
Splicing and spliceosome formation of the yeastMATa1transcript require a minimum distance from the 5' splice site to the internal branch acceptor site [PDF]
, 1988 Karl Köhrer, Horst Domdey
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European Journal of Haematology, EarlyView.ABSTRACT The evolution of acute myeloid leukemia (AML) classifications has progressively shifted the diagnostic focus toward genetic criteria. Nevertheless, morphology remains a key element in clinical practice, often serving as the initial trigger for additional molecular investigations. The diagnosis of acute erythroleukemia (AEML), initially defined
Laurène Fenwarth +23 more
wiley +1 more source
A novel set of spliceosome-associated proteins and the essential splicing factor PSF bind stably to pre-mRNA prior to catalytic step II of the splicing reaction. [PDF]
, 1994 Or Gozani, James G. Patton, Robin Reed
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Past, present, and future strategies for detecting and quantifying circular RNA variants
The FEBS Journal, EarlyView.Originally considered artifact of RNA splicing, over 3 million circular RNAs have been found in humans alone through a combination of ultrasensitive detection methods and bespoke bioinformatics tools. This review covers past, present, and future strategies for detecting and quantifying circular RNAs and how they are illuminating novel circular RNA ...
He Lin, Vanessa M. Conn, Simon J. Conn
wiley +1 more source
PLoS ONE, 2012 Human p29 is a putative component of spliceosomes, but its role in pre-mRNA is elusive. By siRNA knockdown and stable overexpression, we demonstrated that human p29 is involved in DNA damage response and Fanconi anemia pathway in cultured cells.
Chia-Hsin Chen +8 more
doaj +1 more source