Direct Interactions between Pre-mRNA and Six U2 Small Nuclear Ribonucleoproteins during Spliceosome Assembly [PDF]
, 1994 David Staknis, Robin Reed
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Matching maternal and paternal experiences underpin molecular thermal acclimation
Molecular Ecology, EarlyView.Abstract The environment experienced by one generation has the potential to affect the subsequent one through non‐genetic inheritance of parental effects. Since both mothers and fathers can influence their offspring, questions arise regarding how the maternal, paternal and offspring experiences integrate into the resulting phenotype.
L. C. Bonzi +5 more
wiley +1 more source
New Phytologist, EarlyView.Summary Alternative splicing is essential for plants, enabling a single gene to produce multiple transcript variants to boost functional diversity and fine‐tune responses to environmental and developmental cues. Arabidopsis thaliana At‐RS31, a plant‐specific splicing factor in the Serine/Arginine‐rich (SR) protein family, responds to light and the ...
Tino Köster +18 more
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The yeast PRP19 protein is not tightly associated with small nuclear RNAs, but appears to associate with the spliceosome after binding of U2 to the pre-mRNA and prior to formation of the functional spliceosome. [PDF]
, 1993 Woan‐Yuh Tarn +2 more
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Alternative Splicing Regulation in Metabolic Disorders
Obesity Reviews, EarlyView.ABSTRACT Alternative splicing (AS) is a fundamental mechanism for enhancing transcriptome diversity and regulating gene expression, crucial for various cellular processes and the development of complex traits. This review examines the role of AS in metabolic disorders, including obesity, weight loss, dyslipidemias, and metabolic syndrome.
Dorota Kaminska
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Veterinary Clinical Pathology, EarlyView.Abstract Acute myeloid leukemia (AML) poses significant challenges in veterinary medicine, with limited treatment options and poor survival rates. While substantial progress has been made in characterizing human AML, translating these advancements to veterinary practice has been hindered by limited molecular understanding and diagnostic tools. The case
R. Adam Harris +5 more
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Quantitative single-cell splicing analysis reveals an ‘economy of scale’ filter for gene expression [PDF]
, 2018 In eukaryotic cells, splicing affects the fate of each pre-mRNA transcript, helping to determine whether it is ultimately processed into an mRNA, or degraded. The efficiency of splicing plays a key role in gene expression.
Ding, Fangyuan, Elowitz, Michael B.
core
An intimate view of a spliceosome component
eLife, 2015 A high-resolution structure reveals how the ribonucleoprotein particle called U1 snRNP engages with 5′ splice sites.
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Unveiling roles of non‐coding RNAs in cancer through advanced technologies
Quantitative Biology, Volume 13, Issue 4, December 2025.Abstract Non‐coding RNAs (ncRNAs) have emerged as key regulators in tumorigenesis. In this perspective, we briefly review the significance of ncRNA in cancer biology and highlight recent technological advancements in characterization of ncRNA in cancer research. Specifically, we discuss how these advanced approaches, such as Patho‐DBiT, CRISPR screens,
Runhao Wang, Leng Han
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Prp43: An RNA helicase-like factor involved in spliceosome disassembly [PDF]
, 1997 Jaime E. Arenas, John Abelson
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