Results 131 to 140 of about 17,120 (319)
Splicing factor 3B subunit 1 interacts with HIV Tat and plays a role in viral transcription and reactivation from latency [PDF]
, 2018 The main obstacle to an HIV cure is the transcriptionally inert proviruses that persist in resting CD4 T cells and other reservoirs. None of the current approaches has significantly reduced the size of the viral reservoir.
Kyei, George B +6 more
core +2 more sources
CryoEM structures of two spliceosomal complexes: starter and dessert at the spliceosome feast
Current Opinion in Structural Biology, 2016 The spliceosome is formed on pre-mRNA substrates from five small nuclear ribonucleoprotein particles (U1, U2, U4/U6 and U5 snRNPs), and numerous non-snRNP factors. Saccharomyces cerevisiae U4/U6.U5 tri-snRNP comprises U5 snRNA, U4/U6 snRNA duplex and approximately 30 proteins and represents a substantial part of the spliceosome before activation ...
Nguyen, Thi Hoang Duong +5 more
openaire +2 more sources
Integrative Zoology, EarlyView.Symbiotic gill and nonsymbiotic mantle of mussel Gigantidas haimaensis responded differently to deep‐sea sampling stress caused by acute environmental changes. Sharply increased transcription factors potentially play key roles in initiating the response of sampled deep‐sea macrobenthos to the sampling stress.
Guoyong YAN +4 more
wiley +1 more source
Comparative validation of the D. melanogaster modENCODE transcriptome annotation [PDF]
, 2014 Accurate gene model annotation of reference genomes is critical for making them useful. The modENCODE project has improved the D. melanogaster genome annotation by using deep and diverse high-throughput data.
Chen, Zhen-Xia, Sternberg, Paul W.
core
Integrative Zoology, EarlyView.Protein processing in the endoplasmic reticulum is highlighted in response to heat stress in Platysternon megacephalum. Under heat stress, the up‐regulation of genes such as CHOP in protein processing in the endoplasmic reticulum pathway, along with the suppression of energy and lipid metabolism and the up‐regulation of JARID2 expression, leads to ...
Jian Hong +7 more
wiley +1 more source
YIPF2 regulates genome integrity
Cell & BioscienceUnderstanding of the mechanisms for genome integrity maintenance can help in developing effective intervention strategies to combat aging. A whole-genome RNAi screen was conducted to identify novel factors involved in maintaining genome stability.
Xiao Zhang, Tao Wang
doaj +1 more source
Clinical management of CMML—State of the art
British Journal of Haematology, EarlyView.Patients with chronic myelomonocytic leukaemia (CMML) typically present with clinical feature including splenomegaly, constitutional symptoms and autoimmune phenomena, as well as with pathological blood counts and biological features in the marrow. These characteristics may influence the assignment to prognostic categories such as the CPSSmol and also ...
K. Nachtkamp +3 more
wiley +1 more source
A U1 snRNA:pre-mRNA base pairing interaction is required early in yeast spliceosome assembly but does not uniquely define the 5′ cleavage site. [PDF]
, 1988 Bertrand Séraphin +2 more
openalex +1 more source
British Journal of Haematology, EarlyView.Summary The JAK2V617F mutation is associated with increased cardiovascular risk, including ischaemic stroke. This study investigates the prevalence of additional mutations in ischaemic cerebrovascular patients with and without JAK2V617F to better understand the mechanisms contributing to thrombotic risk.
Marie Hvelplund Kristiansen +5 more
wiley +1 more source
Splicing and spliceosome formation of the yeastMATa1transcript require a minimum distance from the 5' splice site to the internal branch acceptor site [PDF]
, 1988 Karl Köhrer, Horst Domdey
openalex +1 more source