Epilepsia, EarlyView.Abstract Objective Developmental and epileptic encephalopathy type 1 (DEE1) is a rare drug‐resistant pediatric epilepsy caused by trinucleotide repeat expansions in the X‐linked ARX gene, leading to elongation of the first polyalanine tract. It presents with early onset tonic seizures or spasms, developmental and cognition delay, and high risk of ...
Lucia Verrillo +9 more
wiley +1 more source
The yeast PRP19 protein is not tightly associated with small nuclear RNAs, but appears to associate with the spliceosome after binding of U2 to the pre-mRNA and prior to formation of the functional spliceosome. [PDF]
, 1993 Woan‐Yuh Tarn +2 more
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Past, present, and future strategies for detecting and quantifying circular RNA variants
The FEBS Journal, EarlyView.Originally considered artifact of RNA splicing, over 3 million circular RNAs have been found in humans alone through a combination of ultrasensitive detection methods and bespoke bioinformatics tools. This review covers past, present, and future strategies for detecting and quantifying circular RNAs and how they are illuminating novel circular RNA ...
He Lin, Vanessa M. Conn, Simon J. Conn
wiley +1 more source
RNA elements and their biotechnological applications in plants
New Phytologist, EarlyView.Summary Engineering of plants for improved traits and efficient heterologous protein production can be achieved by modifying or introducing cis‐ or trans‐acting RNA elements. The function of these elements depends not only on their nucleotide sequence but also on their highly dynamic higher order structures.
Filip Lastovka +3 more
wiley +1 more source
A unified mechanism for intron and exon definition and back-splicing. [PDF]
, 2019 The molecular mechanisms of exon definition and back-splicing are fundamental unanswered questions in pre-mRNA splicing. Here we report cryo-electron microscopy structures of the yeast spliceosomal E complex assembled on introns, providing a view of the ...
Cui, Yanxiang +12 more
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An intimate view of a spliceosome component
eLife, 2015 A high-resolution structure reveals how the ribonucleoprotein particle called U1 snRNP engages with 5′ splice sites.
openaire +4 more sources
Plant Biotechnology Journal, EarlyView.Summary Zinc (Zn2+) is an essential micronutrient that regulates plant growth, immunity and antiviral defence mechanisms. However, its limited bioavailability often necessitates excessive application, resulting in inefficiencies in production and environmental stress.
Jing Wang +10 more
wiley +1 more source
Use of RNA secondary structure for evolutionary relationships : investigating RNase P and RNase MRP : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Genetics at Massey University, New Zealand [PDF]
, 1998 Bioinformatics is applied here to examine whether RNA secondary structure data can reflect distant evolutionary relationships. This is important when there is little confidence in sequence data such as when looking at the evolution of RNase MRP (MRP ...
Collins, Lesley Joan
core
Veterinary Clinical Pathology, EarlyView.Abstract Acute myeloid leukemia (AML) poses significant challenges in veterinary medicine, with limited treatment options and poor survival rates. While substantial progress has been made in characterizing human AML, translating these advancements to veterinary practice has been hindered by limited molecular understanding and diagnostic tools. The case
R. Adam Harris +5 more
wiley +1 more source
Developmental expression of the murine spliceosome-associated protein mSAP49 [PDF]
, 1997 Pilar Ruiz‐Lozano +4 more
openalex +1 more source