Results 151 to 160 of about 10,182 (283)

Polyadenylated versions of small non-coding RNAs in Saccharomyces cerevisiae are degraded by Rrp6p/Rrp47p independent of the core nuclear exosome

Microbial Cell
In Saccharomyces cerevisiae, polyadenylated forms of mature (and not precur-sor) small non-coding RNAs (sncRNAs) those fail to undergo proper 3-end mat-uration are subject to an active degradation by Rrp6p and Rrp47p, which does not require the ...
Anusha Chaudhuri, Soumita Paul, Mayukh Banerjea, Biswadip Das   +3 more
doaj   +1 more source

Collagen 17A1 Gene Correction Using Spliceosome Mediated RNA Trans-splicing (SMaRT™) Technology. [PDF]

, 2000
G. Dallinger, M. Puttaraju, Lloyd G. Mitchell, Kim B. Yancey, Helmut Hintner, Johann Bauer   +5 more
openalex   +1 more source

PUF60‐Regulated Isoform Switching of MAZ Modulates Gastric Cancer Cell Migration

Cancer Medicine, Volume 14, Issue 11, June 2025.
ABSTRACT Background As an essential transcription factor, Myc‐associated zinc‐finger protein (MAZ) is frequently upregulated in many human tumors and is a well‐documented oncogene. However, we found high expression of MAZ was closely associated with good survival outcomes in patients with stomach adenocarcinoma (STAD), and the underlying mechanism ...
Dong Xing, Ting Zhao, Chenchen Mao, Zheng Han, Wanxia Cai, Teming Zhang, Dianfeng Mei, Wangkai Xie, Jiaye Yu, Zhonghan Wu, Zhiyuan Chen, Shiyu Feng, Xian Shen, Xiangyang Xue, Dan Xiang   +14 more
wiley   +1 more source

LncRNA evf‐2 Exacerbates Podocyte Injury in Diabetic Nephropathy by Inducing Cell Cycle Re‐entry and Inflammation Through Distinct Mechanisms Triggered by hnRNPU

Advanced Science
Albuminuria is a hallmark of diabetic nephropathy (DN). Podocyte injury significantly contributes to proteinuria in DN. Our study found that lncRNA EVF‐2 is upregulated in podocytes of DN patients, correlating with cell cycle re‐entry and inflammation ...
Chaojie Zhang, Hui Zhao, Yufan Yan, Yanfei Li, Min Lei, Yong Liu, Longhua Yang, Huijian Zhao, Sijie Zhou, Shaokang Pan, Zhangsuo Liu, Jia Guo   +11 more
doaj   +1 more source

Platelets: Novel Biomaterials for Cancer Diagnosis and Therapeutic Delivery

MedComm – Biomaterials and Applications, Volume 4, Issue 2, June 2025.
Platelets, particularly tumor‐educated platelets (TEPs), play a crucial role in cancer diagnosis and treatment. TEPs undergo molecular changes in RNA and protein profiles, making them valuable biomarkers for diagnosis, prognosis, and monitoring. In nanomedicine, platelets serve as drug carriers in tumor‐targeted nanomaterials, enhancing specificity and
Xin Wang, Jie Chen, Hubing Shi
wiley   +1 more source

Carotid Plaque‐Derived Small Extracellular Vesicles Mediate Atherosclerosis and Correlate With Plaque Vulnerability

MedComm, Volume 6, Issue 6, June 2025.
We profiled the differences in miRNA expression of plaque‐derived small extracellular vesicles (psEVs) from stable and vulnerable plaques of patients with asymptomatic carotid artery stenosis (aCAS), and identified five plasma‐derived sEV miRNAs as potential biomarkers for diagnosing plaque vulnerability.
Xin Xu, Taoyuan Lu, Yao Feng, Wenbo Cao, Dianwei Liu, Peng Gao, Yan Ma, Yabing Wang, Bin Yang, Yanfei Chen, Jian Chen, Ran Xu, Xinyu Wang, Lebin Chen, Yuanyuan Ji, Liqun Jiao   +15 more
wiley   +1 more source

Utility of oligonucleotide in upregulating circular RNA production in a cellular model

Scientific Reports
Circular RNAs (circRNAs), are a covalently closed, single-stranded RNA without 5′- and 3′-termini, commonly stem from the exons of precursor mRNAs (pre-mRNAs).
Lu Ni, Takeshi Yamada, Kazuhiko Nakatani
doaj   +1 more source

Clonal hematopoiesis of indeterminate potential and the risk of autoimmune diseases

Journal of Internal Medicine, Volume 297, Issue 6, Page 642-656, June 2025.
Abstract Background Clonal hematopoiesis of indeterminate potential (CHIP), characterized by the age‐related expansion of blood cells carrying preleukemic mutations, is associated with immune aging. This study aimed to investigate the association between CHIP and established autoimmune diseases. Methods We analyzed baseline data from 456,692 UK Biobank
Hanzhang Wu, Jiahe Wei, Yuefeng Yu, Ningjian Wang, Xiao Tan   +4 more
wiley   +1 more source

A base-pairing interaction between U2 and U6 small nuclear RNAs occurs in > 150S complexes in HeLa cell extracts: implications for the spliceosome assembly pathway.

, 1993
David A. Wassarman, J A Steitz
openalex   +1 more source

HalALMT1 mediates malate efflux in the cortex of mature cluster rootlets of Hakea laurina, occurring naturally in severely phosphorus‐impoverished soil

New Phytologist, Volume 246, Issue 6, Page 2597-2616, June 2025.
Summary Hakea laurina, a woody Proteaceae, naturally occurs in severely phosphorus (P)‐impoverished habitats in southwest Australia. It develops distinctive cluster roots that exhibit a high capacity for carboxylate exudation and acid phosphatase activity, contributing to its P acquisition.
Hirotsuna Yamada, Lydia Ratna Bunthara, Akira Tanaka, Takuro Kohama, Hayato Maruyama, Wakana Tanaka, Sho Nishida, Tantriani, Akira Oikawa, Keitaro Tawaraya, Toshihiro Watanabe, Shu Tong Liu, Patrick M. Finnegan, Hans Lambers, Takayuki Sasaki, Jun Wasaki   +15 more
wiley   +1 more source