Results 131 to 140 of about 16,641 (185)

Squalene epoxidase as hypocholesterolemic drug target revisited

Progress in Lipid Research, 2003
Therapeutic success of statins has distinctly established inhibition of de novo hepatic cholesterol synthesis as an effective approach to lower plasma LDL-cholesterol, the major risk factor for atherosclerosis and coronary heart disease. Statins inhibit HMG CoA reductase, a rate limiting enzyme which catalyses conversion of HMG CoA to mevalonic acid ...
Anita, Chugh, Abhijit, Ray, Jung B, Gupta   +2 more
exaly   +3 more sources

In vitro assay of squalene epoxidase of Saccharomyces cerevisiae

Biochemical and Biophysical Research Communications, 1987
We describe a simple assay for measuring squalene epoxidase specific activity in Saccharomyces cerevisiae cell-free extracts, by using [14C] farnesyl pyrophosphate as substrate. Cofactor requirements for activity are FAD and NADPH or NADH, NADPH being the preferred reduced pyridine nucleotide.
B, M'Baya, F, Karst
openaire   +2 more sources

Squalene epoxidase as a promising metabolic target in cancer treatment

Cancer Letters, 2018
Oncogenic alteration of the cholesterol synthesis pathway is a recognized mechanism of metabolic adaptation. In the present review, we focus on squalene epoxidase (SE), one of the two rate-limiting enzymes in cholesterol synthesis, retracing its history since its discovery as an antimycotic target to its description as an emerging metabolic oncogene by
Edoardo Isnaldi, Gabriele Zoppoli, Alberto Ballestrero   +2 more
exaly   +3 more sources

Properties of a particulate squalene epoxidase from Candida albicans

Lipids and Lipid Metabolism, 1984
The properties and requirements of squalene epoxidase and effects of some inhibitors were investigated in the pathogenic yeast Candida albicans. A washed 'microsomal' fraction converted radiolabelled squalene to 2,3-oxidosqualene and lanosterol. Minimum requirements for activity were molecular oxygen, NADH or NADPH, and FAD.
Neil S Ryder, N S Ryder
exaly   +3 more sources

Phytochemical inhibitors of squalene epoxidase: Integrated In silico and In vitro mechanistic insights for targeting cholesterol biosynthesis.

Archives of Biochemistry and Biophysics
Squalene epoxidase (SQLE) is a critical enzyme in the sterol biosynthesis pathway and a promising therapeutic target for various diseases. This study investigates the inhibitory potential of six phytochemicals, amentoflavone, dihydromyricetin, withaferin
Emadeldin M. Kamel, D. A. Abdelrheem, B. Salah, Al Mokhtar Lamsabhi   +3 more
semanticscholar   +1 more source

Regulation of squalene synthetase and squalene epoxidase activities insaccharomyces cerevisiae

Lipids, 1989
AbstractSqualene synthetase (EC 2.5.1.21) and squalene epoxidase (EC 1.14 99.7) activities have been measured in cell‐free extracts of wild type yeast grown in aerobic and semianaerobic conditions as well as in sterol‐auxotrophic mutant strains grown aerobically.
B, M'Baya, M, Fegueur, M, Servouse, F, Karst   +3 more
openaire   +2 more sources

Multidimensional insights into squalene epoxidase drug development: in vitro mechanisms, in silico modeling, and in vivo implications

Expert opinion on therapeutic targets
Introduction Squalene epoxidase (SQLE) is a pivotal enzyme in sterol biosynthesis, catalyzing the conversion of squalene to 2,3-oxidosqualene. Beyond its core role in cholesterol homeostasis, SQLE is implicated in cancer, hypercholesterolemia, and fungal
A. A. Allam, H. Rudayni, Noha A. Ahmed, Faris F. Aba Alkhayl, Al Mokhtar Lamsabhi, Emadeldin M. Kamel   +5 more
semanticscholar   +1 more source

Detection of squalene epoxidase mutations in U.S. onychomycosis patients: implications for management.

Journal of Investigative Dermatology, 2023
Resistance to oral terbinafine, the most commonly used antifungal to treat dermatophytosis and onychomycosis worldwide, is being increasingly reported. In this study, we aimed to investigate the species distribution and prevalence of squalene epoxidase ...
Aditya K. Gupta, E. Cooper, Tong Wang, S. Ravi, Sara A. Lincoln, V. Piguet, L. R. Mccarthy, Wayne L. Bakotic   +7 more
semanticscholar   +1 more source

Synthesis of potential inhibitors of squalene epoxidase

Journal of the Chemical Society, Perkin Transactions 1, 1991
Squalene was degraded to tris-norsqualene aldehyde, and this was converted into 2-fluoromethyl-, 2,2-difluoromethyl-, 2 -trimethylsilylmethyl -analogues of squalene, and into 2-cyano-norsqualene.
John Mann, Garrick P. Smith
openaire   +1 more source

Squalene epoxidase promotes breast cancer progression by regulating CCNB1 protein stability.

Experimental Cell Research, 2023
BACKGROUND Breast cancer (BC) is a prevalent malignancy affecting women, characterized by a substantial occurrence rate. Squalene epoxidase (SQLE) is a crucial regulator of ferroptosis and has been associated with promoting cell growth and invasion in ...
Dilihumaer Tuluhong, Hongyu Gao, Xinfang Li, Lulu Wang, Yue Zhu, Cheng Xu, Jingjie Wang, Hanjun Li, Qiurong Li, Shaohua Wang   +9 more
semanticscholar   +1 more source