Emerging Terbinafine Resistance in Trichophyton: Clinical Characteristics, Squalene Epoxidase Gene Mutations, and a Reliable EUCAST Method for Detection. [PDF]
Antimicrob Agents Chemother, 2019 Saunte DML +9 more
europepmc +1 more source
Squalene Epoxidase Correlates E-Cadherin Expression and Overall Survival in Colorectal Cancer Patients: The Impact on Prognosis and Correlation to Clinicopathologic Features [PDF]
J Clin Med, 2019 Kim JH, Kim CN, Kang DW.
europepmc +1 more source
Mutation in the Squalene Epoxidase Gene of Trichophyton interdigitale and Trichophyton rubrum Associated with Allylamine Resistance. [PDF]
Antimicrob Agents Chemother, 2018 Rudramurthy SM +7 more
europepmc +1 more source
Studies on Antifungal Compounds Inhibiting Squalene Epoxidase
Journal of Pesticide Science, 2002 openaire +2 more sources
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Squalene epoxidase (SQLE) is a key enzyme in the cholesterol biosynthesis pathway and an attractive therapeutic target for hypercholesterolemia and antifungal treatment.
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Arabidopsis Squalene Epoxidase 3 (SQE3) Complements SQE1 and Is Important for Embryo Development and Bulk Squalene Epoxidase Activity [PDF]
Molecular Plant, 2015 The existence of multigenic families in the mevalonate pathway suggests divergent functional roles for pathway components involved in the biosynthesis of plant sterols. Squalene epoxidases (SQEs) are key components of this pathway, and Squalene Epoxidase 1 (SQE1) has been identified as a fundamental enzyme in this biosynthetic step. In the present work,
Abel Rosado +2 more
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Nucleotide sequence of a cDNA for mouse squalene epoxidase
Biochimica Et Biophysica Acta Gene Regulatory Mechanisms, 1995A full-length cDNA encoding mouse squalene epoxidase was isolated by screening a mouse liver cDNA library with the rat squalene epoxidase gene as a probe. The cDNA had an open reading frame for a 572 amino acid polypeptide with a calculated molecular mass of 63.8 kDa. The predicted amino acid sequence of the mouse enzyme contained an FAD-binding motif,
Shingo Hata, T Osumi, J Sakakibara
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Preclinical toxicology profile of squalene epoxidase inhibitors
Toxicology and Applied Pharmacology, 2020Small cell lung cancer (SCLC) is a particularly aggressive subset of lung cancer, and identification of new therapeutic options is of significant interest. We recently reported that SCLC cell lines display a specific vulnerability to inhibition of squalene epoxidase (SQLE), an enzyme in the cholesterol biosynthetic pathway that catalyzes the conversion
Raj, Nagaraja +9 more
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Inhibition and activation of porcine squalene epoxidase
Archives of Biochemistry and Biophysics, 1992Pig liver squalene epoxidase (SE) has been partially purified from solubilized microsomes by DEAE-Sephacel and Blue Sepharose 4B chromatography. This stable and reproducible preparation was used to investigate the mechanism of several substrate-like inhibitors of SE and to study the effects of pH, metals, detergents, and cofactors on enzyme activity ...
M, Bai, G D, Prestwich
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Detailed Mechanism of Squalene Epoxidase Inhibition by Terbinafine
Journal of Chemical Information and Modeling, 2011Squalene epoxidase (SE) is a key flavin adenine dinucleotide (FAD)-dependent enzyme of ergosterol and cholesterol biosynthetic pathways and an attractive potential target for drugs used to inhibit the growth of pathogenic fungi or to lower cholesterol level. Although many studies on allylamine drugs activity have been published during the last 30 years,
Marcin Nowosielski +7 more
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