Results 151 to 160 of about 16,641 (185)

Synthesis and Biological Activity of a Novel Squalene Epoxidase Inhibitor, FR194738.

ChemInform, 2004
AbstractFor Abstract see ChemInform Abstract in Full Text.
Masae, Sawada, Ken ichi, Washizuka, Hiroyuki, Okumura   +2 more
openaire   +2 more sources

Epoxidation of 2,3-oxidosqualene to 2,3;22,23-squalene dioxide by squalene epoxidase.

Biochemical and biophysical research communications, 1992
Partially purified squalene epoxidase (SE) from pig liver converts 2,3-oxidosqualene (SO) to 2,3;22,23-squalene dioxide (SDO) with approximately one-half the efficiency of the epoxidation of squalene at pH 7.4. The SO to SDO conversion is independent of pH and shows an absolute requirement for exogenous FAD.
M, Bai, X Y, Xiao, G D, Prestwich
openaire   +1 more source

Terbinafine: Mode of action and properties of the squalene epoxidase inhibition

British Journal of Dermatology, 1992
Terbinafine (Lamisil) has primarily fungicidal action against many fungi as a result of its specific mechanism of squalene epoxidase inhibition. Treated fungi accumulate squalene while becoming deficient in ergosterol, an essential component of fungal cell membranes.
openaire   +2 more sources

Abstract 1550: Identification of a novel squalene epoxidase function in breast cancer brain metastasis

Cancer Research
Brain metastases are serious complications of breast cancer, especially in triple-negative breast cancer (TNBC) patients. There is currently no effective treatment due to the unique brain microenvironment and limitation for drugs to cross the blood ...
Shu-Ping Wang, Jia-Yun Yeh, Y. Lee, Kun-Yuan Lin, C. Chang, Chih-Chieh Yang, Shan-Yun Cheng, Y. Hung, Yu-Hsien Chang, Yaohui Li, Yung-Lung Yu   +10 more
semanticscholar   +1 more source

Prolonged treatment of dermatophytosis caused by Trichophyton indotinea with terbinafine or itraconazole impacts better outcomes irrespective of mutation in the squalene epoxidase gene

Mycoses (Berlin)
Over the past decades, the increasing incidence of recurrent dermatophytosis associated with terbinafine‐resistant Trichophyton has posed a serious challenge in management of dermatophytosis.
D. Shaw, S. Dogra, Shreya Singh, Shikha Shah, Tarun Narang, H. Kaur, K. Walia, Anup K. Ghosh, Sanjeev Handa, Arunaloke Chakrabarti, S. Rudramurthy   +10 more
semanticscholar   +1 more source

Squalene Epoxidase: A Key Enzymatic Component in the Triterpenoid Biosynthesis Pathway

Applied Biochemistry and Biotechnology
Squalene epoxidase (SE) is located in the microsomes of the endoplasmic reticulum and acts as a biocatalyst in the biological process where squalene is converted into 2,3-oxidosqualene (MOS). As a precursor for the biosynthesis pathways of important secondary metabolites such as triterpenes, the catalytic efficiency of SE influences the biosynthetic ...
Di, Liu, Xiaofan, Yu, Sanyu, Qin, Tingting, Zheng, Xintong, Bao, Xinqin, Li   +5 more
openaire   +2 more sources

Squalene Epoxidase Inhibitors

1992
Neil S. Ryder, Anton Stuetz, Peter Nussbaumer   +2 more
openaire   +1 more source

Squalene epoxidase as a target for the allylamines

Biochemical Society Transactions, 1991
openaire   +2 more sources

Advances in understanding the role of squalene epoxidase in cancer prognosis and resistance

Molecular Biology Reports
Jiazhuang Zhu, Yongjie Wang, Kunpeng Zhu, Chunlin Zhang   +3 more
semanticscholar   +1 more source

Mechanistic Insights into Polyphenols-mediated Squalene Epoxidase Inhibition: Computational Models and Experimental Validation for Targeting Cholesterol Biosynthesis

Cell Biochemistry and Biophysics
Emadeldin M. Kamel, A. A. Allam, H. Rudayni, Saleh Alkhedhairi, F. Alkhayl, Maha A. Alwaili, Al Mokhtar Lamsabhi   +6 more
semanticscholar   +1 more source