Phosphorylation of Unique domains of Src family kinases [PDF]
Frontiers in Genetics, 2014 Members of the Src family of kinases (SFKs) are non-receptor tyrosine kinases involved innumerous signal transduction pathways. The catalytic, SH3 and SH2 domains are attached tothe membrane-anchoring SH4 domain through the intrinsically disordered ...
Irene eAmata +3 more
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Src mediates cytokine-stimulated gene expression in airway myocytes through ERK MAPK [PDF]
Cell Communication and Signaling, 2011 The p38 and extracellular signal-regulated kinases (ERK) mitogen-activated protein kinases (MAPK) participate in cytokine-stimulated inflammatory gene expression in airway smooth muscle cells.
Halayko Andrew J +4 more
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The Src-Family Kinases SRC and BLK Contribute to the CLDN6-Adhesion Signaling [PDF]
Cells, 2023 Cell adhesion molecules, including integrins, cadherins, and claudins (CLDNs), are known to activate Src-family kinases (SFKs) that organize a variety of physiological and pathological processes; however, the underlying molecular basis remains unclear ...
Naoki Ichikawa-Tomikawa +3 more
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Src family kinases, adaptor proteins and the actin cytoskeleton in epithelial-to-mesenchymal transition [PDF]
Cell Communication and Signaling, 2021 Over a century of scientific inquiry since the discovery of v-SRC but still no final judgement on SRC function. However, a significant body of work has defined Src family kinases as key players in tumor progression, invasion and metastasis in human ...
Maria A. Ortiz +5 more
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Platelet Src family kinases: A tale of reversible phosphorylation [PDF]
Research and Practice in Thrombosis and Haemostasis, 2021 Sarcoma (Src) family kinases (SFKs) have occupied a central place in platelet research for over 40 years. Discovered by virologists and oncologists as the proto proto‐oncogene, Src tyrosine kinase spurred a phenomenal burst of research on reversible ...
Yotis A. Senis +4 more
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Src family kinases engage differential pathways for encapsulation into extracellular vesicles [PDF]
Journal of Extracellular Biology, 2023 Extracellular vesicles (EVs) are heterogeneous biological nanoparticles secreted by all cell types. Identifying the proteins preferentially encapsulated in secreted EVs will help understand their heterogeneity.
Chenming Ye +10 more
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Characterization of Novel Src Family Kinase Inhibitors to Attenuate Microgliosis. [PDF]
PLoS ONE, 2015 Microgliosis is a major hallmark of Alzheimer's disease (AD) brain pathology. Aβ peptide is hypothesized to act as a stimulus for microglia leading to activation of non-receptor tyrosine kinases and subsequent secretion of pro-inflammatory cytokines ...
Gunjan D Manocha +5 more
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Src Family Kinases and p38 Mitogen-Activated Protein Kinases Regulate Pluripotent Cell Differentiation in Culture. [PDF]
PLoS ONE, 2016 Multiple pluripotent cell populations, which together comprise the pluripotent cell lineage, have been identified. The mechanisms that control the progression between these populations are still poorly understood.
Boon Siang Nicholas Tan +9 more
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Src Family Kinases: A Potential Therapeutic Target for Acute Kidney Injury [PDF]
Biomolecules, 2022 Src family kinases (SFKs) are non-receptor tyrosine kinases and play a key role in regulating signal transduction. The mechanism of SFKs in various tumors has been widely studied, and there are more and more studies on its role in the kidney.
Nannan Li +8 more
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Pharmacological inhibition of Src family kinases attenuates hyperuricemic nephropathy [PDF]
Frontiers in PharmacologyHyperuricemia is an independent risk factor for chronic kidney disease and contributes to renal fibrosis. This study aims to investigate the effect of Src family kinase (SFK) inhibition on the development of hyperuricemic nephropathy (HN) and the ...
Chongxiang Xiong +5 more
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