Src Family Kinases Inhibition Ameliorates Hypoxic-Ischemic Brain Injury in Immature Rats [PDF]
Frontiers in Cellular Neuroscience, 2021 Hypoxic-ischemic (HI) injury is one of the initial factors contributing to neonatal brain injury. Src family kinases (SFKs) are considered to act as molecular hubs for N-methyl-d-aspartate receptor (NMDAR) regulation and participate in the HI injury ...
Han Qiu +5 more
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The interplay between Src family kinases and receptor tyrosine kinases. [PDF]
Oncogene, 2004 Src family tyrosine kinases (SFKs) are involved in a diverse array of physiological processes, as highlighted in this review. An overview of how SFKs interact with, and participate in signaling from, receptor tyrosine kinases (RTKs) is discussed.
Bromann, Paul Andrew +2 more
core +4 more sources
Structural insights into redox-active cysteine residues of the Src family kinases [PDF]
Redox Biology, 2021 The Src Family Kinases (SFKs) are pivotal regulators of cellular signal transduction and highly sought-after targets in drug discovery. Their actions within cells are controlled by alterations in protein phosphorylation that switch the SFKs from ...
David E. Heppner
doaj +2 more sources
Regulation of the Src Family Kinases by Csk [PDF]
International Journal of Biological Sciences, 2012 The non-receptor tyrosine kinase Csk serves as an indispensable negative regulator of the Src family tyrosine kinases (SFKs) by specifically phosphorylating the negative regulatory site of SFKs, thereby suppressing their oncogenic potential.
Masato Okada
doaj +3 more sources
Src family kinases in chronic kidney disease. [PDF]
Am J Physiol Renal Physiol, 2017 Src family kinases (SFKs) belong to nonreceptor protein tyrosine kinases and have been implicated in the regulation of numerous cellular processes, including cell proliferation, differentiation, migration and invasion, and angiogenesis. The role and mechanisms of SFKs in tumorgenesis have been extensively investigated, and some SFK inhibitors are ...
Wang J, Zhuang S.
europepmc +3 more sources
Targeting SRC Family Kinases in Mesothelioma: Time to Upgrade. [PDF]
Cancers (Basel), 2020 Malignant mesothelioma (MM) is a deadly tumor mainly caused by exposure to asbestos. Unfortunately, no current treatment is able to change significantly the natural history of the disease, which has a poor prognosis in the majority of patients. The non-receptor tyrosine kinase SRC and other SRC family kinase (SFK) members are frequently hyperactivated ...
Indovina P +3 more
europepmc +6 more sources
Mindin regulates fibroblast subpopulations through distinct Src family kinases during fibrogenesis [PDF]
JCI InsightFibrosis results from excessive extracellular matrix (ECM) deposition, which causes tissue stiffening and organ dysfunction. Activated fibroblasts, central to fibrosis, exhibit increased migration, proliferation, contraction, and ECM production. However,
Sunny Kataria +14 more
doaj +2 more sources
Expression of myeloid Src-family kinases is associated with poor prognosis in AML and influences Flt3-ITD kinase inhibitor acquired resistance. [PDF]
PLoS ONE, 2019 Unregulated protein-tyrosine kinase signaling is a common feature of AML, often involving mutations in Flt3 and overexpression of myeloid Src-family kinases (Hck, Fgr, Lyn).
Ravi K Patel +5 more
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Csk controls leukocyte extravasation via local regulation of Src family kinases and cortactin signaling. [PDF]
Front ImmunolStegmeyer RI +8 more
europepmc +3 more sources
The tyrosine kinase Csk dimerizes through Its SH3 domain. [PDF]
PLoS ONE, 2009 The Src family kinases possess two sites of tyrosine phosphorylation that are critical to the regulation of kinase activity. Autophosphorylation on an activation loop tyrosine residue (Tyr 416 in commonly used chicken c-Src numbering) increases catalytic
Nicholas M Levinson +2 more
doaj +1 more source