Results 31 to 40 of about 113,366 (301)

Profiling Y561-dependent and -independent substrates of CSF-1R in epithelial cells. [PDF]

PLoS ONE, 2010
Receptor tyrosine kinases (RTKs) activate multiple downstream cytosolic tyrosine kinases following ligand stimulation. SRC family kinases (SFKs), which are recruited to activated RTKs through SH2 domain interactions with RTK autophosphorylation sites ...
Melodie L Knowlton, Laura M Selfors, Carolyn N Wrobel, Ting-Lei Gu, Bryan A Ballif, Steven P Gygi, Roberto Polakiewicz, Joan S Brugge   +7 more
doaj   +1 more source

c-Src drives intestinal regeneration and transformation [PDF]

, 2014
The non‐receptor tyrosine kinase c‐Src, hereafter referred to as Src, is overexpressed or activated in multiple human malignancies. There has been much speculation about the functional role of Src in colorectal cancer (CRC), with Src amplification and ...
Cordero, Julia B., Frame, Margaret, Muller, William J., Nixon, Colin, Ridgway, Rachel A., Sansom, Owen J., Valeri, Nicola, Vidal, Marcos   +7 more
core   +3 more sources

Src kinases are required for a balanced production of IL-12/IL-23 in human dendritic cells activated by Toll-like receptor agonists. [PDF]

PLoS ONE, 2010
BACKGROUND: Pathogen recognition by dendritic cells (DC) is crucial for the initiation of both innate and adaptive immune responses. Activation of Toll-like Receptors (TLRs) by microbial molecular patterns leads to the maturation of DC, which present the
Mirela Kuka, Roberta Baronio, Sara Valentini, Elisabetta Monaci, Alessandro Muzzi, Susanna Aprea, Ennio De Gregorio, Ugo D'Oro   +7 more
doaj   +1 more source

Binding, domain orientation, and dynamics of the Lck SH3-SH2 domain pair and comparison with other Src-family kinases [PDF]

, 2005
The catalytic activity of Src-family kinases is regulated by association with its SH3 and SH2 domains. Activation requires displacement of intermolecular contacts by SH3/SH2 binding ligands resulting in dissociation of the SH3 and SH2 domains from the ...
Bolen J. B., Brown M. T., Thomas S. M., Williams J. C., Xu W., Sicheri F., Mustelin T., Moarefi I., Young M. A., Eck M. J., Arold S. T., Fushman D., Ulmer T. S., Schweimer K., Chou J. J., Ruckert M., Kay L. E., Kay L. E., Farrow N. A., Boyd J., Kay L. E., Werner J. M., Lipari G., Palmer A. G., Mandel A. M., Boyd J., Woessner D. E., Press W. H., Ottiger M., Dosset P., Morton C. J., Schweimer K., Hartley D. A., Wiese N., Songyang Z., Morelock M. M., Bauer F., Courtneidge S. A., Kaplan D. R., Dunant N. M., Pelosi M., Tjandra N., Losonczi J. A., Clore G. M., Zamoyska R., Abbreviations HMTA   +45 more
core   +2 more sources

Inhibition of Food Intake by PACAP in the Hypothalamic Ventromedial Nuclei is Mediated by NMDA Receptors [PDF]

, 2014
Central injections of pituitary adenylate cyclase-activating polypeptide (PACAP) into the ventromedial nuclei (VMN) of the hypothalamus produce hypophagia that is dependent upon the PAC1 receptor; however, the signaling downstream of this receptor in the
Choi, Sujean, Maunze, Brian, Phillips, Kailynn A., Resch, Jon M   +3 more
core   +2 more sources

The Src family kinases: distinct functions of c-Src, Yes, and Fyn in the liver

Biomolecular Concepts, 2013
The Src family kinases Yes, Fyn, and c-Src play a pivotal role in regulating diverse liver functions such as bile flow, proteolysis, apoptosis, and proliferation and are regulated by anisoosmotic cell volume changes, death receptor ligands, and bile ...
Reinehr Roland, Sommerfeld Annika, Häussinger Dieter   +2 more
doaj   +1 more source

Ca²⁺ Signaling and Src Functions in Tumor Cells

Biomolecules, 2023
Signaling by calcium ion (Ca2+) plays a prominent role in cell physiology, and these mechanisms are frequently altered in tumor cells. In this review, we consider the interplay of Ca2+ signaling and the functions of the proto-oncogene non-receptor ...
Antonio Villalobo
doaj   +1 more source

Essential Role of Lyn in Fibrosis. [PDF]

, 2016
Fibrotic disorders involve replacement of normal parenchyma with myofibroblasts, which deposit connective tissue, leading to obliteration of the function of the underlying organ.
Birtolo, Chiara, Chheda, Chintan, Cirulli, Vincenzo, Gugliotta, Gabriele, Lewis, Michael S, Liu, Sandy T, Pandol, Stephen J, Pham, Hung, Ptasznik, Andrzej, Rodriguez, Maria D, Yang, Wendy   +10 more
core   +2 more sources

Recruitment of Lyn from endomembranes to the plasma membrane through calcium-dependent cell-cell interactions upon polarization of inducible Lyn-expressing MDCK cells

Scientific Reports, 2017
Src-family kinases, expressed in a wide variety of cell types, are anchored to cellular membranes through posttranslational lipid modifications and involved in diverse cellular signalling.
Takao Morinaga, Sayuri Yanase, Aya Okamoto, Noritaka Yamaguchi, Naoto Yamaguchi   +4 more
doaj   +1 more source

FUS-CHOP promotes invasion in myxoid liposarcoma through a SRC/FAK/RHO/ROCK-dependent pathway [PDF]

, 2017
Deregulated SRC/FAK signaling leads to enhanced migration and invasion in many types of tumors. In myxoid and round cell liposarcoma (MRCLS), an adipocytic tumor characterized by the expression of the fusion oncogene FUS-CHOP, SRC have been found as one ...
González, M. Victoria, Hermida Prado, Francisco, Singh Singh, Ranjit, Tornin Cavielles, Juan   +3 more
core   +2 more sources