Results 51 to 60 of about 113,366 (301)
Prion-associated Increases in Src-family Kinases [PDF]
Journal of Biological Chemistry, 2005 The prion diseases result from the generation and propagation of an abnormal conformer of the prion protein. It is unclear how this molecular event disrupts neuronal function and viability. Current evidence argues it is not due to loss of normal prion protein activity or direct toxic effects of the abnormal conformer. Both the normal and abnormal prion
openaire +2 more sources
PLoS ONE, 2018 Studies have demonstrated that the solute carrier family 11 member 1 (SLC11A1) is heavily glycosylated and phosphorylated in macrophages. However, the mechanisms of SLC11A1 phosphorylation, and the effects of phosphorylation on SLC11A1 activity remain ...
Yong Zhong Xu +4 more
doaj +1 more source
Real-time analysis of imatinib- and dasatinib-induced effects on chronic myelogenous leukemia cell interaction with fibronectin. [PDF]
PLoS ONE, 2014 Attachment of stem leukemic cells to the bone marrow extracellular matrix increases their resistance to chemotherapy and contributes to the disease persistence.
Adam Obr +3 more
doaj +1 more source
Targeting Btk/Etk of prostate cancer cells by a novel dual inhibitor. [PDF]
, 2014 Btk and Etk/BMX are Tec-family non-receptor tyrosine kinases. Btk has previously been reported to be expressed primarily in B cells and has an important role in immune responses and B-cell malignancies.
Bhardwaj, G +16 more
core +2 more sources
GRID and docking analyses reveal a molecular basis for flavonoid inhibition of src-family kinase activity [PDF]
, 2015 Flavonoids reduce cardiovascular disease risk through anti-inflammatory, anti-coagulant and anti-platelet actions. One key flavonoid inhibitory mechanism is blocking kinase activity that drives these processes.
Gibbins, Jon M. +4 more
core +1 more source
SRC kinase-mediated signaling pathways and targeted therapies in breast cancer
Breast Cancer Research, 2022 Breast cancer (BC) has been ranked the most common malignant tumor throughout the world and is also a leading cause of cancer-related deaths among women. SRC family kinases (SFKs) belong to the non-receptor tyrosine kinase (nRTK) family, which has eleven
Juan Luo +9 more
doaj +1 more source
Development of the Sensing Platform for Protein Tyrosine Kinase Activity
Biosensors, 2021 A miniature tyrosinase-based electrochemical sensing platform for label-free detection of protein tyrosine kinase activity was developed in this study. The developed miniature sensing platform can detect the substrate peptides for tyrosine kinases, such ...
Lan-Yi Wei +5 more
doaj +1 more source
Phosphorylation of CLEC-2 is dependent on lipid rafts, actin polymerization,secondary mediators, and Rac [PDF]
, 2010 The C-type lectin-like receptor 2 (CLEC-2)activates platelets through Src and Syk tyrosine kinases via a single cytoplasmic YxxL motif known as a hem immunoreceptor tyrosine-based activation motif (hemITAM).Here, we demonstrate using sucrose gradient ...
Alice Y. Pollitt +44 more
core +1 more source
A novel anti-melanoma SRC-family kinase inhibitor [PDF]
Oncotarget, 2019 The major drawback of melanoma therapy with BRAF and MAPK inhibitors is the innate and acquired drug resistance. We therefore explored alternative targets and developed a new compound, SAB298, that is a SRC-family kinase (SFK) inhibitor. The drug is cytotoxic to patient-derived melanoma cells regardless of oncogene expression and inhibits tumor growth ...
Halaban, Ruth +8 more
openaire +2 more sources
Endocytosis and the Src family of non-receptor tyrosine kinases
Biomolecular Concepts, 2014 The regulated intracellular transport of nutrient, adhesion, and growth factor receptors is crucial for maintaining cell and tissue homeostasis. Endocytosis, or endocytic membrane trafficking, involves the steps of intracellular transport that include ...
Reinecke James, Caplan Steve
doaj +1 more source