Results 71 to 80 of about 44,786 (250)

Impact of Janus Kinase Inhibition with Tofacitinib on Fundamental Processes of Bone Healing [PDF]

, 2020
Both inflammatory diseases like rheumatoid arthritis (RA) and anti-inflammatory treatment of RA with glucocorticoids (GCs) or non-steroidal anti-inflammatory drugs (NSAIDs) negatively influence bone metabolism and fracture healing.
Brinkman, Antonia Clara Katharina, Burmester, Gerd-Rüdiger, Buttgereit, Frank, Damerau, Alexandra, Diesing, Karoline, Gaber, Timo, Hoff, Paula, Lang, Annemarie, Ohrndorf, Sarah, Pfeiffenberger, Moritz, Pienczikowski, Justyna   +10 more
core   +1 more source

Recapitulating Endochondral Ossification for Bone Repair: From Development to Engineering Strategy

Advanced Healthcare Materials, EarlyView.
This review summarizes the developmental basis of endochondral ossification (ECO) and its applications in bone tissue engineering (BTE). It first outlines the key biological processes and signaling pathways underlying ECO, then discusses biomaterial‐based engineering strategies derived from these principles, and finally highlights future directions for
Yiqi Su, Zihao He, Qianqian Chen, Long Chen, Caiyi Wei, Zijin Zhou, Jianhao Lin, Hui Li, Dan Xing   +8 more
wiley   +1 more source

Generation of Human Epidermis-Derived Mesenchymal Stem Cell-like Pluripotent Cells and their reprogramming in mouse chimeras [PDF]

, 2011
Stem cells can be derived from the embryo (embryonic stem cells, ESCs), from adult tissues (adult stem cells, ASCs), and by induction of fibroblasts (induced pluripotent stem cells, iPSs).
Bing Huang, Jian Ge, JianFa Huang, Jie Yu, KaiJing Li, LiPing Guan, LiPing Lin, Min Zhang, QianYing Gao, ShaoChun Lin, Ting Luo, WeiHua Li, WenCong Wang, WenXin Zhang, XiaoPing Xu, XiGu Chen, XinMing Song, XinTao Huang, YiChi Zhang, YongLiang Lin, YongPing Li, ZhiChong Wang   +21 more
core   +1 more source

Female Sex Development and Reproductive Duct Formation Depend on Wnt4a in Zebrafish. [PDF]

, 2019
In laboratory strains of zebrafish, sex determination occurs in the absence of a typical sex chromosome and it is not known what regulates the proportion of animals that develop as males or females.
Bruce W. Draper, John H. Postlethwait, Michelle E. Kossack, Parr, Rachel E. Hopton, Samantha K. High, Takahashi, Uchida, Yi-lin Yan   +8 more
core   +1 more source

Restoring Iron Homeostasis via Smoothened Inhibition: A Novel Strategy Against Hearing Loss

Advanced Science, EarlyView.
 . ABSTRACT Sensorineural hearing loss (SNHL) induced by noise or aminoglycoside antibiotics is a significant public health concern without any FDA‐approved pharmaceutical therapies. Dysregulation of iron homeostasis and its subsequently induced ferroptosis has increasingly been identified as a key mechanism underlying cochlear hair cell (HC) damage ...
Huanyu Mao, Xiang Li, Yaqi Liao, Liman Liu, Xian Gao, Hailiang Lin, Wenli Ni, Huawei Li, Yan Chen, Wenyan Li   +9 more
wiley   +1 more source

Unveiling combinatorial regulation through the combination of ChIP information and in silico cis-regulatory module detection [PDF]

, 2012
Computationally retrieving biologically relevant cis-regulatory modules (CRMs) is not straightforward. Because of the large number of candidates and the imperfection of the screening methods, many spurious CRMs are detected that are as high scoring as ...
Fierro, Ana Carolina, Guns, Tias, Marchal, Kathleen, Nijssen, Siegfried, Sun, Hong, Thorrez, Lieven   +5 more
core   +2 more sources

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Low genetic variability, female-biased dispersal and high movement rates in an urban population of Eurasian badgersMeles meles [PDF]

, 2008
1. Urban and rural populations of animals can differ in their behaviour, both in order to meet their ecological requirements and due to the constraints imposed by different environments.
Bijlsma, Brownstein, Carpenter, Carpenter, Carpenter, Cheeseman, Christian, Clements, Cresswell, da Silva, Davison, Davison, Ditchkoff, Domingo-Roura, Doncaster, Dugdale, Dugdale, Engel, Estes, Evans, Favre, Frantz, Frantz, Frantz, Gottelli, Griffiths, Hardy, Harris, Harris, Huck, Huck, Huck, Kalinowski, Kowalczyk, Kruuk, Langbein, Loiselle, Macdonald, Marmi, Marshall, McKelvey, McKelvey, Miller, Miller, Mills, Page, Pertoldi, Pope, Queller, Raymond, Roper, Rousset, Scheppers, Schley, Smal, Taberlet, Taberlet, Taylor, Tuyttens, Tuyttens, van Oosterhout, Vekemans, Waits, Walsh, Wilberg, Woodroffe, Woodroffe   +66 more
core   +2 more sources

Multi‐Omics Insights Into the Mechanisms of Early Muscle Fiber Difference and Transformation Between Lean‐Type and Chinese Indigenous Pigs

Advanced Science, EarlyView.
Multi‐omics analyses uncover breed‐specific cis‐regulatory landscapes and higher‐order chromatin architectural differences that underlie early postnatal muscle fiber divergence in pigs. A super‐enhancer upstream of PPP3CB recruits MEF2C to activate PPP3CB transcription, while the PPP3CB–MEF2C positive feedback loop promotes oxidative muscle fiber ...
Shuailong Zheng, Hainan Wu, Min Liu, Kunpeng Wu, Shuntao Huang, Zulfiqar Ahmed, Lenox Pius, Mengjin Zhu, Dequan Xu   +8 more
wiley   +1 more source

A review of evidence on non-invasive prenatal diagnosis (NIPD) : tests for fetal RHD genotype [PDF]

, 2007
This report concentrates on three main areas. First and foremost, we set the background context for RhD NIPD in prenatal care. While the methodology chapter describes how the literature review was carried out and how additional information was collected,
Clay, Diane, Freeman, Karoline, HASH(0x55aa091d4640), Hyde, Julia, Osipenko, Leeza, Szczepura, Ala   +5 more
core