Results 91 to 100 of about 44,786 (250)
Cbx2, a Polycomb Group Gene, Is Required for Sry Gene Expression in Mice [PDF]
Endocrinology, 2012 Mice lacking the function of the polycomb group protein CBX2 (chromobox homolog 2; also known as M33) show defects in gonadal, adrenal, and splenic development. In particular, XY knockout (KO) mice develop ovaries but not testes, and the gonads are hypoplastic in both sexes.
Katoh-Fukui, Yuko +12 more
openaire +3 more sources
Role of SoxE transcription factors in development and disease
Developmental Dynamics, EarlyView.Abstract Sox8, Sox9, and Sox10 arose by multiple rounds of genome duplications from a single SoxE gene in ancestral vertebrates. In this review, we will briefly discuss the molecular structure and function of SoxE transcription factors and their evolutionary origin. We will then discuss their expression, function, and developmental disorders.
Merin Lawrence, Gerhard Schlosser
wiley +1 more source
Quantitative profiling of selective Sox/POU pairing on hundreds of sequences in parallel by Coop-seq [PDF]
, 2016 © The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research. Cooperative binding of transcription factors is known to be important in the regulation of gene expression programs conferring cellular identities.
Chang, Yiming K +8 more
core +3 more sources
Epilepsia Open, EarlyView.Abstract Objective The pathogenesis of epilepsy is closely associated with neuronal synaptic plasticity. MicroRNAs (miRNAs) can regulate various biological processes by binding to specific sequences on target genes. This study employs bioinformatics, molecular dynamics, and experimental approaches to investigate the mechanism by which MiR‐30a‐5p treats
Zhenlin Yang +4 more
wiley +1 more source
Maternal urinary cell free fetal DNA in relation to gestational age
Middle East Fertility Society Journal, 2016 Objectives: To evaluate the presence of cell-free fetal DNA in the maternal urine in relation to gestational age as a potential source for non-invasive prenatal diagnosis. Material and methods: One hundred and sixty normal pregnant women were included in
Mona Mohamed Shaban +6 more
doaj +1 more source
Head &Neck, EarlyView.ABSTRACT Background Salivary gland carcinomas are uncommon malignancies with various histological subtypes harboring fusion genes. The EWSR1::ATF1 fusion gene, resulting from a translocation between chromosomes 12 and 22, is frequently observed in hyalinizing clear cell carcinoma (HCCC). However, the role of this fusion gene in HCCC oncogenesis remains
Yuri Hirai +13 more
wiley +1 more source
Brain Sexual Differentiation and Requirement of SRY: Why or Why Not?
Frontiers in Neuroscience, 2017 Brain sexual differentiation is orchestrated by precise coordination of sex steroid hormones. In some species, programming of select male brain regions is dependent upon aromatization of testosterone to estrogen.
Cheryl S. Rosenfeld +3 more
doaj +1 more source
A del(X)(p11) carrying
BMC Pediatrics, 2006 Background SRY (sex-determining region, Y) is the gene responsible of gonadal differentiation in the male and it is essential for the regular development of male genitalia.
Abd El-Fatah S +7 more
doaj +1 more source
Polytene chromosomes as indicators of phylogeny in several species groups of Drosophila. [PDF]
, 2001 BackgroundPolytene chromosome banding patterns have long been used by Drosophila evolutionists to infer degree of relatedness among taxa. Recently, nucleotide sequences have preempted this traditional method.
Baker, RH +4 more
core
The pig X and Y Chromosomes: structure, sequence, and evolution. [PDF]
, 2015 We have generated an improved assembly and gene annotation of the pig X Chromosome, and a first draft assembly of the pig Y Chromosome, by sequencing BAC and fosmid clones from Duroc animals and incorporating information from optical mapping and fiber ...
Affara, Nabeel A +34 more
core +5 more sources