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RpoE-mediated virulence attenuation elicits protective immunity in hypervirulent Klebsiella pneumoniae

Emerging Microbes and Infections
The global emergence of hypervirulent Klebsiella pneumoniae (hvKP) and extensively drug-resistant (XDR) phenotypes has precipitated a severe public health crisis with limited therapeutic options.
Yaxuan Zhai +14 more
doaj +1 more source

The nationwide genomic characteristics and phylogenetic evolution of ST23-K1 hypervirulent Klebsiella pneumoniae in relation to virulence and antimicrobial resistance acquisition

Journal of Infection
Hypervirulent Klebsiella pneumoniae (hvKp) ST23-K1 poses a global health threat due to its high virulence and increasing antimicrobial resistance. This study aimed to characterise the genomic feature and phylogenetic evolution of ST23-K1 in China.K1 isolates from a nationwide epidemiological surveillance project underwent whole-genome sequencing ...
Qiucheng Shi +13 more
openaire +2 more sources

Comparative genomic analysis of clinical isolates of Klebsiella pneumoniae isolated from newborns with different outcomes of the infectious process in the neonatal period

Журнал микробиологии, эпидемиологии и иммунобиологии
Introduction. Some progress has been made in the study of the molecular mechanisms of antibiotic resistance, namely, genes and their variants have been identified that ensure the inactivation of beta-lactam antibiotics.
Alexander V. Ustyuzhanin +3 more
doaj +1 more source

Comment on: MDR carbapenemase-producingKlebsiella pneumoniaeof the hypervirulence-associated ST23 clone in Poland, 2009–19