Results 11 to 20 of about 2,576 (168)
Stargazin Modulation of AMPA Receptors [PDF]
Cell Reports, 2016 Fast excitatory synaptic signaling in the mammalian brain is mediated by AMPA-type ionotropic glutamate receptors. In neurons, AMPA receptors co-assemble with auxiliary proteins, such as stargazin, which can markedly alter receptor trafficking and gating.
Sana A. Shaikh +7 more
doaj +4 more sources
A Role for Stargazin in Experience-Dependent Plasticity
Cell Reports, 2014 During development, neurons are constantly refining their connections in response to changes in activity. Experience-dependent plasticity is a key form of synaptic plasticity, involving changes in α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid ...
Susana R. Louros +4 more
doaj +4 more sources
Stargazin Dephosphorylation Mediates Homeostatic Synaptic Downscaling of Excitatory Synapses [PDF]
Frontiers in Molecular Neuroscience, 2018 Synaptic scaling is a form of homeostatic plasticity that is critical for maintaining neuronal activity within a dynamic range, and which alters synaptic strength through changes in postsynaptic AMPA-type glutamate receptors.
Susana R. Louros +3 more
doaj +4 more sources
Genetic absence epilepsy rats from Strasbourg have increased corticothalamic expression of stargazin
Neurobiology of Disease, 2008 Stargazin is membrane bound protein involved in trafficking, synapse anchoring and biophysical modulation of AMPA receptors. A quantitative trait locus in chromosome 7 containing the stargazin gene has been identified as controlling the frequency and ...
K.L. Powell +7 more
doaj +3 more sources
Differences in Src phosphorylation of PSD-93 and PSD-95 drive differences in scaffolding activity. [PDF]
Protein SciAbstract Scaffold proteins contain multiple binding modules that allow for co‐localization of proteins that lack a direct interaction. Evolution resulted in different combinations of binding modules that rewired existing signal transduction pathways.
Mindlin FA +3 more
europepmc +2 more sources
Notes on the History of In Vitro Hippocampal Electrophysiology and LTP: Personal Reflections. [PDF]
HippocampusABSTRACT This essay describes the development of the in vitro hippocampal slice technique and my small contributions to it and to influencing Roger Nicoll's early interests in the hippocampus and LTP. My Ph.D. work at Harvard with Timothy Teyler was on field potential studies of synaptic plasticity, including LTP, in the rat in vitro hippocampal slice.
Alger BE.
europepmc +2 more sources
Molecular physiology of Arc/Arg3.1: The oligomeric state hypothesis of synaptic plasticity. [PDF]
Acta Physiol (Oxf), 2022 Abstract The immediate early gene, Arc, is a pivotal regulator of synaptic plasticity, memory, and cognitive flexibility. But what is Arc protein? How does it work? Inside the neuron, Arc is a protein interaction hub and dynamic regulator of intra‐cellular signaling in synaptic plasticity.
Eriksen MS, Bramham CR.
europepmc +2 more sources
Autoinactivation of the stargazin-AMPA receptor complex: subunit-dependency and independence from physical dissociation. [PDF]
PLoS ONE, 2012 Agonist responses and channel kinetics of native α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors are modulated by transmembrane accessory proteins.
Artur Semenov +4 more
doaj +1 more source
Genes, Brain and Behavior, Volume 22, Issue 6, December 2023., 2023 Variations in the Dlg2 gene have been linked to increased risk for psychiatric disorders. Here, we tested these predicted effects with a behavioural characterisation of the heterozygous Dlg2+/‐ rat model. Dlg2+/‐ rats exhibited a mild impairment in reversal learning but only in a substrate deterministic bowl‐digging reversal learning task.
Simonas Griesius +9 more
wiley +1 more source
Phenotypic heterogeneity in the stargazin allelic series [PDF]
Mammalian Genome, 2003 The stargazer mutant mouse is characterized by its ataxic gait, head tossing, and absence seizures. The mutation was identified in the gamma 2 subunit gene of the high voltage-dependent calcium channel, Cacng2. Subsequently, two allelic variants of stargazer have arisen, waggler and stargazer 3J. In this study, we have compared these new alleles to the
Letts, V A +6 more
openaire +3 more sources