Stargazin Modulation of AMPA Receptors [PDF]
Fast excitatory synaptic signaling in the mammalian brain is mediated by AMPA-type ionotropic glutamate receptors. In neurons, AMPA receptors co-assemble with auxiliary proteins, such as stargazin, which can markedly alter receptor trafficking and gating.
Sana A. Shaikh+7 more
doaj +5 more sources
A Role for Stargazin in Experience-Dependent Plasticity
During development, neurons are constantly refining their connections in response to changes in activity. Experience-dependent plasticity is a key form of synaptic plasticity, involving changes in α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid ...
Susana R. Louros+4 more
doaj +5 more sources
Caspase-1/IL-1β represses membrane transport of GluA1 by inhibiting the interaction between Stargazin and GluA1 in Alzheimer’s disease [PDF]
Background Alzheimer's disease is a neurodegenerative disease. Previous study has reported that caspase-1/IL-1β is closely associated with Alzheimer's disease.
Xunhu Gu+5 more
doaj +2 more sources
The Impact of Glutamatergic Synapse Dysfunction in the Corticothalamocortical Network on Absence Seizure Generation [PDF]
Childhood absence epilepsy (CAE) is the most common pediatric epilepsy affecting 10–18% of all children with epilepsy. It is genetic in origin and the result of dysfunction within the corticothalamocortical (CTC) circuitry.
Beulah Leitch
doaj +2 more sources
Regulation of the Stability and Localization of Post-synaptic Membrane Proteins by Liquid-Liquid Phase Separation [PDF]
Synaptic plasticity is a cellular mechanism of learning and memory. The synaptic strength can be persistently upregulated or downregulated to update the information sent to the neuronal network and form a memory engram.
Tomohisa Hosokawa, Pin-Wu Liu
doaj +2 more sources
Site-specific phosphorylation of PSD-95 dynamically regulates the postsynaptic density as observed by phase separation [PDF]
Summary: Postsynaptic density protein 95 is a key scaffolding protein in the postsynaptic density of excitatory glutamatergic neurons, organizing signaling complexes primarily via its three PSD-95/Discs-large/Zona occludens domains.
Maria Vistrup-Parry+10 more
doaj +2 more sources
Advances in understanding the pathogenesis of epilepsy: Unraveling the molecular mechanisms: A cross-sectional study. [PDF]
Abstract Introduction Epilepsy is characterized by having two or more unprovoked seizures. Understanding the pathogenesis of epilepsy, requires deep investigation into the molecular mechanisms. This helps develop diagnostic techniques, treatments, and pharmacotherapy. It also enhances precision medicine and individualized treatment processes.
Shariff S+7 more
europepmc +2 more sources
Aberrant hippocampal transmission and behavior in mice with a stargazin mutation linked to intellectual disability. [PDF]
Caldeira GL+14 more
europepmc +3 more sources
Mechanism of Modulation of AMPA Receptors by Stargazin [PDF]
AMPA receptors (AMPARs) mediate most of the fast excitatory synaptic transmission in the brain. Native AMPARs typically form heterotetrameric complexes and associate with a variety of auxiliary subunits. Stargazin (gamma2) is the prototype and most studied member of the transmembrane AMPA receptor regulatory proteins family, and regulates several ...
Anna L. Carbone, Andrew J.R. Plested
openalex +3 more sources
Phosphorylation of Stargazin by Protein Kinase A Regulates Its Interaction with PSD-95 [PDF]
Stargazin is the first transmembrane protein known to associate with AMPA (alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate) glutamate receptors (AMPARs) and regulate their synaptic targeting by two distinct mechanisms, specifically via delivery of AMPARs to the surface membrane and synaptic targeting of these receptors by binding to PSD-95/SAP-90 ...
Jeonghoon Choi+6 more
openalex +4 more sources