Results 11 to 20 of about 2,711 (196)
A Role for Stargazin in Experience-Dependent Plasticity
Cell Reports, 2014 During development, neurons are constantly refining their connections in response to changes in activity. Experience-dependent plasticity is a key form of synaptic plasticity, involving changes in α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid ...
Susana R. Louros +4 more
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Mechanism of Modulation of AMPA Receptors by Stargazin [PDF]
Biophysical Journal, 2014 AMPA receptors (AMPARs) mediate most of the fast excitatory synaptic transmission in the brain. Native AMPARs typically form heterotetrameric complexes and associate with a variety of auxiliary subunits. Stargazin (gamma2) is the prototype and most studied member of the transmembrane AMPA receptor regulatory proteins family, and regulates several ...
Anna L. Carbone, Andrew J.R. Plested
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Autoinactivation of the stargazin-AMPA receptor complex: subunit-dependency and independence from physical dissociation. [PDF]
PLoS ONE, 2012 Agonist responses and channel kinetics of native α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors are modulated by transmembrane accessory proteins.
Artur Semenov +4 more
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Targeted sensors for glutamatergic neurotransmission [PDF]
eLife, 2023 Optical report of neurotransmitter release allows visualisation of excitatory synaptic transmission. Sensitive genetically-encoded fluorescent glutamate reporters operating with a range of affinities and emission wavelengths are available.
Yuchen Hao +4 more
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Phosphorylation of Stargazin by Protein Kinase A Regulates Its Interaction with PSD-95 [PDF]
Journal of Biological Chemistry, 2002 Stargazin is the first transmembrane protein known to associate with AMPA (alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate) glutamate receptors (AMPARs) and regulate their synaptic targeting by two distinct mechanisms, specifically via delivery of AMPARs to the surface membrane and synaptic targeting of these receptors by binding to PSD-95/SAP-90 ...
Jeonghoon Choi +6 more
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Caspase-1/IL-1β represses membrane transport of GluA1 by inhibiting the interaction between Stargazin and GluA1 in Alzheimer’s disease [PDF]
Molecular Medicine, 2021 Background Alzheimer's disease is a neurodegenerative disease. Previous study has reported that caspase-1/IL-1β is closely associated with Alzheimer's disease.
Xunhu Gu +5 more
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Reconstitution of invertebrate glutamate receptor function depends on stargazin-like proteins [PDF]
Proceedings of the National Academy of Sciences, 2006 α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors (AMPARs) are a major subtype of ionotropic glutamate receptors (iGluRs) that mediate rapid excitatory synaptic transmission in the vertebrate brain. Putative AMPARs are also expressed in the nervous system of invertebrates.
Craig S. Walker +8 more
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Roles of stargazin and phosphorylation in the control of AMPA receptor subcellular distribution [PDF]
Nature Neuroscience, 2009 Understanding how the subcellular fate of newly synthesized AMPA receptors (AMPARs) is controlled is important for elucidating the mechanisms of neuronal function. We examined the effect of increased synthesis of AMPAR subunits on their subcellular distribution in rat hippocampal neurons. Virally expressed AMPAR subunits (GluR1 or GluR2) accumulated in
Helmut W. Kessels +3 more
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Further characterization of regulation of CaV2.2 by Stargazin [PDF]
Channels, 2010 Stargazin, a transmembrane protein expressed in the nervous system, shares similarities with the γ₁ subunit of skeletal muscle calcium channels. It was thus termed γ₂ subunit of neuronal calcium channels. Stargazin downregulates the expression of Ca(V)2 channels, however, its functional modulation of these channels remains debated.
Isabella Farhy Tselnicker, Nathan Dascal
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Stargazin is an AMPA receptor auxiliary subunit [PDF]
Proceedings of the National Academy of Sciences, 2005 AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptors mediate fast excitatory synaptic transmission in brain and underlie aspects of synaptic plasticity. Numerous AMPA receptor-binding proteins have been implicated in AMPA receptor trafficking and anchoring.
Wim Vandenberghe +2 more
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