Genetic absence epilepsy rats from Strasbourg have increased corticothalamic expression of stargazin
Neurobiology of Disease, 2008 Stargazin is membrane bound protein involved in trafficking, synapse anchoring and biophysical modulation of AMPA receptors. A quantitative trait locus in chromosome 7 containing the stargazin gene has been identified as controlling the frequency and ...
K.L. Powell +7 more
doaj +4 more sources
CaMKII Triggers the Diffusional Trapping of Surface AMPARs through Phosphorylation of Stargazin [PDF]
Neuron, 2010 The Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) is critically required for the synaptic recruitment of AMPA-type glutamate receptors (AMPARs) during both development and plasticity. However, the underlying mechanism is unknown. Using single-particle tracking of AMPARs, we show that CaMKII activation and postsynaptic translocation induce the ...
P. Opazo +6 more
semanticscholar +4 more sources
Aberrant hippocampal transmission and behavior in mice with a stargazin mutation linked to intellectual disability. [PDF]
Mol Psychiatry, 2022 Mutations linked to neurodevelopmental disorders, such as intellectual disability (ID), are frequently found in genes that encode for proteins of the excitatory synapse.
Caldeira GL +14 more
europepmc +2 more sources
Stargazin is an AMPA receptor auxiliary subunit [PDF]
Proceedings of the National Academy of Sciences, 2005 AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptors mediate fast excitatory synaptic transmission in brain and underlie aspects of synaptic plasticity. Numerous AMPA receptor-binding proteins have been implicated in AMPA receptor trafficking and anchoring.
Wim Vandenberghe +2 more
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Human neuronal stargazin-like proteins, γ2, γ3 and γ4; an investigation of their specific localization in human brain and their influence on CaV2.1 voltage-dependent calcium channels expressed in
BMC Neuroscience, 2003 Background Stargazin (γ2) and the closely related γ3, and γ4 transmembrane proteins are part of a family of proteins that may act as both neuronal voltage-dependent calcium channel (VDCC) γ subunits and transmembrane α-amino-3-hydroxy-5-methyl-4 ...
Dolphin Annette C +2 more
doaj +2 more sources
Different Domains of the AMPA Receptor Direct Stargazin-mediated Trafficking and Stargazin-mediated Modulation of Kinetics [PDF]
Journal of Biological Chemistry, 2006 Stargazin is an accessory protein of AMPA receptors that enhances surface expression and also affects the biophysical properties of the receptor. AMPA receptor domains necessary for either of these two processes have not yet been identified. Here, we used confocal imaging and electrophysiology of heterologously expressed, fluorophore-tagged GluR1 ...
Matthew A. Bedoukian +2 more
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The tetraspanin TSPAN5 regulates AMPAR exocytosis by interacting with the AP4 complex [PDF]
eLife, 2023 Intracellular trafficking of AMPA receptors is a tightly regulated process which involves several adaptor proteins, and is crucial for the activity of excitatory synapses both in basal conditions and during synaptic plasticity.
Edoardo Moretto +7 more
doaj +2 more sources
Stargazin and γ4 slow the channel opening and closing rates of GluA4 AMPA receptors [PDF]
Scientific Reports, 2019 As auxiliary subunits, transmembrane AMPA receptor regulatory proteins (TARPs) are known to enhance macroscopic current amplitude and alter kinetic properties of AMPA receptors on slow time scale, such as desensitization rate.
Vincen D. Pierce, L. Niu
semanticscholar +2 more sources
Differences in Src phosphorylation of PSD-93 and PSD-95 drive differences in scaffolding activity. [PDF]
Protein SciAbstract Scaffold proteins contain multiple binding modules that allow for co‐localization of proteins that lack a direct interaction. Evolution resulted in different combinations of binding modules that rewired existing signal transduction pathways.
Mindlin FA +3 more
europepmc +2 more sources
Stargazin and cornichon-3 relieve polyamine block of AMPA receptors by enhancing blocker permeation [PDF]
The Journal of General Physiology, 2018 Most ligand- and voltage-gated ion channels assemble as signaling complexes consisting of pore-forming and auxiliary subunits. In the mammalian brain, AMPA-type ionotropic glutamate receptors (AMPARs) coassemble with several families of auxiliary ...
P. Brown, Hugo McGuire, D. Bowie
semanticscholar +2 more sources