Reconstitution of invertebrate glutamate receptor function depends on stargazin-like proteins [PDF]
α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors (AMPARs) are a major subtype of ionotropic glutamate receptors (iGluRs) that mediate rapid excitatory synaptic transmission in the vertebrate brain. Putative AMPARs are also expressed in the nervous system of invertebrates.
Craig S. Walker+8 more
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Further characterization of regulation of CaV2.2 by Stargazin [PDF]
Stargazin, a transmembrane protein expressed in the nervous system, shares similarities with the γ₁ subunit of skeletal muscle calcium channels. It was thus termed γ₂ subunit of neuronal calcium channels. Stargazin downregulates the expression of Ca(V)2 channels, however, its functional modulation of these channels remains debated.
Isabella Farhy Tselnicker, Nathan Dascal
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AMPA Receptor Modulation by Stargazin [PDF]
Sana Shaikh+7 more
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A new role for stargazin [PDF]
Rachel K. Jones
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Roles of stargazin and phosphorylation in the control of AMPA receptor subcellular distribution [PDF]
Understanding how the subcellular fate of newly synthesized AMPA receptors (AMPARs) is controlled is important for elucidating the mechanisms of neuronal function. We examined the effect of increased synthesis of AMPAR subunits on their subcellular distribution in rat hippocampal neurons. Virally expressed AMPAR subunits (GluR1 or GluR2) accumulated in
Helmut W. Kessels+3 more
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Slow AMPAR Synaptic Transmission Is Determined by Stargazin and Glutamate Transporters [PDF]
AMPARs mediate the briefest synaptic currents in the brain by virtue of their rapid gating kinetics. However, at the mossy fiber-to-unipolar brush cell synapse in the cerebellum, AMPAR-mediated EPSCs last for hundreds of milliseconds, and it has been proposed that this time course reflects slow diffusion from a complex synaptic space. We show that upon
Hsin-Wei Lu+3 more
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Bidirectional Synaptic Plasticity Regulated by Phosphorylation of Stargazin-like TARPs [PDF]
Synaptic plasticity involves protein phosphorylation cascades that alter the density of AMPA-type glutamate receptors at excitatory synapses; however, the crucial phosphorylated substrates remain uncertain. Here, we show that the AMPA receptor-associated protein stargazin is quantitatively phosphorylated and that stargazin phosphorylation promotes ...
Susumu Tomita+4 more
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Molecular Mechanism of AMPA Receptor Modulation by TARP/Stargazin [PDF]
AMPA receptors (AMPARs) mediate the majority of fast excitatory transmission in the brain and critically contribute to synaptic plasticity and pathology. AMPAR trafficking and gating are tightly controlled by auxiliary transmembrane AMPAR regulatory proteins (TARPs).
Anat Ben-Yaacov+5 more
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Stargazin is an AMPA receptor auxiliary subunit [PDF]
AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptors mediate fast excitatory synaptic transmission in brain and underlie aspects of synaptic plasticity. Numerous AMPA receptor-binding proteins have been implicated in AMPA receptor trafficking and anchoring.
Wim Vandenberghe+2 more
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Different Domains of the AMPA Receptor Direct Stargazin-mediated Trafficking and Stargazin-mediated Modulation of Kinetics [PDF]
Stargazin is an accessory protein of AMPA receptors that enhances surface expression and also affects the biophysical properties of the receptor. AMPA receptor domains necessary for either of these two processes have not yet been identified. Here, we used confocal imaging and electrophysiology of heterologously expressed, fluorophore-tagged GluR1 ...
Matthew A. Bedoukian+2 more
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