Results 21 to 30 of about 2,576 (168)
A new perspective on hippocampal synaptic plasticity and post‐stroke depression
European Journal of Neuroscience, Volume 58, Issue 4, Page 2961-2984, August 2023., 2023 Abstract Post‐stroke depression, a common complication after stroke, severely affects the recovery and quality of life of patients with stroke. Owing to its complex mechanisms, post‐stroke depression treatment remains highly challenging. Hippocampal synaptic plasticity is one of the key factors leading to post‐stroke depression; however, the precise ...
Ning Sun +5 more
wiley +1 more source
Structural properties and peptide ligand binding of the capsid homology domains of human Arc
Biochemistry and Biophysics Reports, 2021 The activity-regulated cytoskeleton-associated protein (Arc) is important for synaptic plasticity and the normal function of the brain. Arc interacts with neuronal postsynaptic proteins, but the mechanistic details of its function have not been fully ...
Erik I. Hallin +2 more
doaj +1 more source
Stargazin is an AMPA receptor auxiliary subunit [PDF]
Proceedings of the National Academy of Sciences, 2005 AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptors mediate fast excitatory synaptic transmission in brain and underlie aspects of synaptic plasticity. Numerous AMPA receptor-binding proteins have been implicated in AMPA receptor trafficking and anchoring.
Wim, Vandenberghe +2 more
openaire +2 more sources
Different Domains of the AMPA Receptor Direct Stargazin-mediated Trafficking and Stargazin-mediated Modulation of Kinetics [PDF]
Journal of Biological Chemistry, 2006 Stargazin is an accessory protein of AMPA receptors that enhances surface expression and also affects the biophysical properties of the receptor. AMPA receptor domains necessary for either of these two processes have not yet been identified. Here, we used confocal imaging and electrophysiology of heterologously expressed, fluorophore-tagged GluR1 ...
Matthew A, Bedoukian +2 more
openaire +2 more sources
Slow excitatory synaptic currents generated by AMPA receptors
The Journal of Physiology, Volume 600, Issue 2, Page 217-232, 15 January 2022., 2022 Abstract figure legend Besides their classical fast responses that depress with repeated stimulation (blue), some forms of AMPA‐type glutamate receptors can produce a current with slow kinetics approaching 0.5 s. A progressive increase in the current (‘pedestal’, orange) produces short‐term potentiation from a postsynaptic locus.
Niccolò P. Pampaloni +1 more
wiley +1 more source
The Journal of Physiology, Volume 600, Issue 2, Page 201-215, 15 January 2022., 2022 Abstract figure legend Retinogeniculate synapses of the dLGN are large synapses with multiple release sites. Pronounced short‐term depression of currents in retinogeniculate synapses results from high release probability and desensitization of AMPA receptors.
Jakob von Engelhardt
wiley +1 more source
Journal of Cellular and Molecular Medicine, Volume 25, Issue 15, Page 7418-7425, August 2021., 2021 Abstract We previously showed a hydroxamic acid‐based histone deacetylase inhibitor (HDACi), compound 13, provides neuroprotection against chronic cerebral hypoperfusion (CCH) both in vitro under oxygen‐glucose deprivation (OGD) conditions and in vivo under bilateral common carotid artery occlusion (BCCAO) conditions.
Yao‐Ching Fang +7 more
wiley +1 more source
High-affinity anti-Arc nanobodies provide tools for structural and functional studies
PLoS ONE, 2022 Activity-regulated cytoskeleton-associated protein (Arc) is a multidomain protein of retroviral origin with a vital role in the regulation of synaptic plasticity and memory formation in mammals.
Sigurbjörn Markússon +9 more
doaj +3 more sources
Ca2+‐permeable AMPA receptors and their auxiliary subunits in synaptic plasticity and disease
The Journal of Physiology, Volume 599, Issue 10, Page 2655-2671, 15 May 2021., 2021 Abstract figure legend AMPARs containing GluA2 (red subunits) are Ca2+‐impermeable (CI‐AMPARs). Those that lack GluA2 are Ca2+‐permeable (CP‐AMPARs) and are implicated in diverse forms of synaptic plasticity and disease. Both native CP‐ and CI‐AMPARs contain various auxiliary subunits (shown as yellow, green or turquoise) that affect AMPAR function and
Stuart G. Cull‐Candy, Mark Farrant
wiley +1 more source
iScience, 2022 Summary: The organization of the postsynaptic density (PSD), a protein-dense semi-membraneless organelle, is mediated by numerous specific protein–protein interactions (PPIs) which constitute a functional postsynapse.
Nikolaj Riis Christensen +9 more
doaj +1 more source