Results 21 to 30 of about 1,323 (153)

Reconstitution of invertebrate glutamate receptor function depends on stargazin-like proteins [PDF]

open access: greenProceedings of the National Academy of Sciences, 2006
α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors (AMPARs) are a major subtype of ionotropic glutamate receptors (iGluRs) that mediate rapid excitatory synaptic transmission in the vertebrate brain. Putative AMPARs are also expressed in the nervous system of invertebrates.
Craig S. Walker   +8 more
openalex   +5 more sources

Further characterization of regulation of CaV2.2 by Stargazin [PDF]

open access: goldChannels, 2010
Stargazin, a transmembrane protein expressed in the nervous system, shares similarities with the γ₁ subunit of skeletal muscle calcium channels. It was thus termed γ₂ subunit of neuronal calcium channels. Stargazin downregulates the expression of Ca(V)2 channels, however, its functional modulation of these channels remains debated.
Isabella Farhy Tselnicker, Nathan Dascal
openalex   +5 more sources

AMPA Receptor Modulation by Stargazin [PDF]

open access: bronzeBiophysical Journal, 2017
Sana Shaikh   +7 more
openalex   +3 more sources

A new role for stargazin [PDF]

open access: bronzeNature Reviews Neuroscience, 2005
Rachel K. Jones
openalex   +3 more sources

Roles of stargazin and phosphorylation in the control of AMPA receptor subcellular distribution [PDF]

open access: greenNature Neuroscience, 2009
Understanding how the subcellular fate of newly synthesized AMPA receptors (AMPARs) is controlled is important for elucidating the mechanisms of neuronal function. We examined the effect of increased synthesis of AMPAR subunits on their subcellular distribution in rat hippocampal neurons. Virally expressed AMPAR subunits (GluR1 or GluR2) accumulated in
Helmut W. Kessels   +3 more
openalex   +5 more sources

Slow AMPAR Synaptic Transmission Is Determined by Stargazin and Glutamate Transporters [PDF]

open access: bronzeNeuron, 2017
AMPARs mediate the briefest synaptic currents in the brain by virtue of their rapid gating kinetics. However, at the mossy fiber-to-unipolar brush cell synapse in the cerebellum, AMPAR-mediated EPSCs last for hundreds of milliseconds, and it has been proposed that this time course reflects slow diffusion from a complex synaptic space. We show that upon
Hsin-Wei Lu   +3 more
openalex   +3 more sources

Bidirectional Synaptic Plasticity Regulated by Phosphorylation of Stargazin-like TARPs [PDF]

open access: bronzeNeuron, 2005
Synaptic plasticity involves protein phosphorylation cascades that alter the density of AMPA-type glutamate receptors at excitatory synapses; however, the crucial phosphorylated substrates remain uncertain. Here, we show that the AMPA receptor-associated protein stargazin is quantitatively phosphorylated and that stargazin phosphorylation promotes ...
Susumu Tomita   +4 more
openalex   +5 more sources

Molecular Mechanism of AMPA Receptor Modulation by TARP/Stargazin [PDF]

open access: bronzeNeuron, 2017
AMPA receptors (AMPARs) mediate the majority of fast excitatory transmission in the brain and critically contribute to synaptic plasticity and pathology. AMPAR trafficking and gating are tightly controlled by auxiliary transmembrane AMPAR regulatory proteins (TARPs).
Anat Ben-Yaacov   +5 more
openalex   +4 more sources

Stargazin is an AMPA receptor auxiliary subunit [PDF]

open access: greenProceedings of the National Academy of Sciences, 2005
AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptors mediate fast excitatory synaptic transmission in brain and underlie aspects of synaptic plasticity. Numerous AMPA receptor-binding proteins have been implicated in AMPA receptor trafficking and anchoring.
Wim Vandenberghe   +2 more
openalex   +3 more sources

Different Domains of the AMPA Receptor Direct Stargazin-mediated Trafficking and Stargazin-mediated Modulation of Kinetics [PDF]

open access: hybridJournal of Biological Chemistry, 2006
Stargazin is an accessory protein of AMPA receptors that enhances surface expression and also affects the biophysical properties of the receptor. AMPA receptor domains necessary for either of these two processes have not yet been identified. Here, we used confocal imaging and electrophysiology of heterologously expressed, fluorophore-tagged GluR1 ...
Matthew A. Bedoukian   +2 more
openalex   +5 more sources

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