Stargazin promotes closure of the AMPA receptor ligand-binding domain [PDF]
Journal of General Physiology, 2014 Stargazin enhances closure of the AMPA receptor ligand-binding domain, thereby facilitating channel activation.
David M. Maclean +4 more
semanticscholar +3 more sources
Bidirectional Synaptic Plasticity Regulated by Phosphorylation of Stargazin-like TARPs [PDF]
Neuron, 2005 Synaptic plasticity involves protein phosphorylation cascades that alter the density of AMPA-type glutamate receptors at excitatory synapses; however, the crucial phosphorylated substrates remain uncertain. Here, we show that the AMPA receptor-associated protein stargazin is quantitatively phosphorylated and that stargazin phosphorylation promotes ...
Susumu Tomita +4 more
openalex +3 more sources
Stargazin controls the pharmacology of AMPA receptor potentiators [PDF]
Proceedings of the National Academy of Sciences, 2006 Glutamate is the major excitatory neurotransmitter in brain, and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors (AMPARs) mediate the majority of postsynaptic depolarization. AMPAR ion channels display rapid gating, and their deactivation and desensitization determine the timing of synaptic transmission.
Susumu Tomita +4 more
openalex +3 more sources
S-nitrosylation of stargazin regulates surface expression of AMPA-glutamate neurotransmitter receptors [PDF]
Proceedings of the National Academy of Sciences, 2009 Synaptic plasticity is mediated by changes in the surface expression of AMPA receptors (AMPARs). Stargazin and related transmembrane AMPAR regulatory proteins have emerged as the principal regulators of AMPAR surface expression. Here, we show in heterologous cells and primary neurons that stargazin is physiologically S-nitrosylated, resulting in ...
B Selvakumar +2 more
openalex +3 more sources
Engineering defined membrane‐embedded elements of AMPA receptor induces opposing gating modulation by cornichon 3 and stargazin [PDF]
Journal of Physiology, 2017 N. Hawken, E. Zaika, T. Nakagawa
semanticscholar +2 more sources
The Stargazin C Terminus Encodes an Intrinsic and Transferable Membrane Sorting Signal [PDF]
Journal of Biological Chemistry, 2007 Activity-dependent plasticity of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors is regulated by their auxiliary subunit, stargazin. Association with stargazin enhances alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor surface expression and modifies the receptor's biophysical properties.
Matthew A. Bedoukian +4 more
openalex +4 more sources
Stargazin Reduces Desensitization and Slows Deactivation of the AMPA-Type Glutamate Receptors [PDF]
The Journal of Neuroscience, 2005 The AMPA-type glutamate receptors mediate the majority of the fast excitatory synaptic transmission and critically contribute to synaptic plasticity in the brain, hence the existence of numerous trafficking proteins dedicated to regulation of their ...
A. Priel +5 more
semanticscholar +4 more sources
A new role for stargazin [PDF]
Nature Reviews Neuroscience, 2005 Rachel K. Jones
openalex +2 more sources
AMPA Receptor Modulation by Stargazin [PDF]
Biophysical Journal, 2017 S. Shaikh +7 more
semanticscholar +2 more sources
Stargazin Modulates Native AMPA Receptor Functional Properties by Two Distinct Mechanisms [PDF]
The Journal of Neuroscience, 2005 AMPA receptors play a central role in basal excitatory synaptic transmission as well as synaptic maturation and plasticity. The transmembrane AMPA receptor regulatory protein (TARP) stargazin (γ2) serves multiple roles in trafficking and stabilizing synaptic AMPA receptors and may be incorporated as an auxiliary subunit.
Dorothy M. Turetsky +2 more
openalex +4 more sources