Results 31 to 40 of about 1,323 (153)

Stargazin attenuates intracellular polyamine block of calcium-permeable AMPA receptors [PDF]

open access: greenNature Neuroscience, 2007
Endogenous polyamines profoundly affect the activity of various ion channels, including that of calcium-permeable AMPA-type glutamate receptors (CP-AMPARs). Here we show that stargazin, a transmembrane AMPAR regulatory protein (TARP) known to influence transport, gating and desensitization of AMPARs, greatly reduces block of CP-AMPARs by intracellular ...
David Soto   +4 more
openalex   +5 more sources

Stargazin controls the pharmacology of AMPA receptor potentiators [PDF]

open access: greenProceedings of the National Academy of Sciences, 2006
Glutamate is the major excitatory neurotransmitter in brain, and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors (AMPARs) mediate the majority of postsynaptic depolarization. AMPAR ion channels display rapid gating, and their deactivation and desensitization determine the timing of synaptic transmission.
Susumu Tomita   +4 more
openalex   +4 more sources

A mild impairment in reversal learning in a bowl‐digging substrate deterministic task but not other cognitive tests in the Dlg2+/− rat model of genetic risk for psychiatric disorder

open access: yesGenes, Brain and Behavior, Volume 22, Issue 6, December 2023., 2023
Variations in the Dlg2 gene have been linked to increased risk for psychiatric disorders. Here, we tested these predicted effects with a behavioural characterisation of the heterozygous Dlg2+/‐ rat model. Dlg2+/‐ rats exhibited a mild impairment in reversal learning but only in a substrate deterministic bowl‐digging reversal learning task.
Simonas Griesius   +9 more
wiley   +1 more source

A new perspective on hippocampal synaptic plasticity and post‐stroke depression

open access: yesEuropean Journal of Neuroscience, Volume 58, Issue 4, Page 2961-2984, August 2023., 2023
Abstract Post‐stroke depression, a common complication after stroke, severely affects the recovery and quality of life of patients with stroke. Owing to its complex mechanisms, post‐stroke depression treatment remains highly challenging. Hippocampal synaptic plasticity is one of the key factors leading to post‐stroke depression; however, the precise ...
Ning Sun   +5 more
wiley   +1 more source

Phenotypic heterogeneity in the stargazin allelic series [PDF]

open access: yesMammalian Genome, 2003
The stargazer mutant mouse is characterized by its ataxic gait, head tossing, and absence seizures. The mutation was identified in the gamma 2 subunit gene of the high voltage-dependent calcium channel, Cacng2. Subsequently, two allelic variants of stargazer have arisen, waggler and stargazer 3J. In this study, we have compared these new alleles to the
Letts, V A   +6 more
openaire   +4 more sources

Slow excitatory synaptic currents generated by AMPA receptors

open access: yesThe Journal of Physiology, Volume 600, Issue 2, Page 217-232, 15 January 2022., 2022
Abstract figure legend Besides their classical fast responses that depress with repeated stimulation (blue), some forms of AMPA‐type glutamate receptors can produce a current with slow kinetics approaching 0.5 s. A progressive increase in the current (‘pedestal’, orange) produces short‐term potentiation from a postsynaptic locus.
Niccolò P. Pampaloni   +1 more
wiley   +1 more source

CaMKII Triggers the Diffusional Trapping of Surface AMPARs through Phosphorylation of Stargazin [PDF]

open access: bronzeNeuron, 2010
The Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) is critically required for the synaptic recruitment of AMPA-type glutamate receptors (AMPARs) during both development and plasticity. However, the underlying mechanism is unknown. Using single-particle tracking of AMPARs, we show that CaMKII activation and postsynaptic translocation induce the ...
Patricio Opazo   +6 more
openalex   +3 more sources

Role of AMPA receptor desensitization in short term depression – lessons from retinogeniculate synapses

open access: yesThe Journal of Physiology, Volume 600, Issue 2, Page 201-215, 15 January 2022., 2022
Abstract figure legend Retinogeniculate synapses of the dLGN are large synapses with multiple release sites. Pronounced short‐term depression of currents in retinogeniculate synapses results from high release probability and desensitization of AMPA receptors.
Jakob von Engelhardt
wiley   +1 more source

The Stargazin C Terminus Encodes an Intrinsic and Transferable Membrane Sorting Signal [PDF]

open access: hybridJournal of Biological Chemistry, 2007
Activity-dependent plasticity of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors is regulated by their auxiliary subunit, stargazin. Association with stargazin enhances alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor surface expression and modifies the receptor's biophysical properties.
Matthew A. Bedoukian   +4 more
openalex   +4 more sources

HDACi protects against vascular cognitive impairment from CCH injury via induction of BDNF‐related AMPA receptor activation

open access: yesJournal of Cellular and Molecular Medicine, Volume 25, Issue 15, Page 7418-7425, August 2021., 2021
Abstract We previously showed a hydroxamic acid‐based histone deacetylase inhibitor (HDACi), compound 13, provides neuroprotection against chronic cerebral hypoperfusion (CCH) both in vitro under oxygen‐glucose deprivation (OGD) conditions and in vivo under bilateral common carotid artery occlusion (BCCAO) conditions.
Yao‐Ching Fang   +7 more
wiley   +1 more source

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