Results 31 to 40 of about 2,576 (168)
Aging Cell, Volume 20, Issue 4, April 2021., 2021 Ageing reduces the number of OPCs and their ‘stemness’. Genomic analysis resolved key mechanisms underpinning the age related decline in OPCs, most notably reduced expression of Gpr17 in a subpopulation of differentiation committed OPCs. Pharmacogenomics identified small molecules that have the potential to rejuvenate OPCs and promote myelination and ...
Andrea D. Rivera +6 more
wiley +1 more source
Stargazin controls the pharmacology of AMPA receptor potentiators [PDF]
Proceedings of the National Academy of Sciences, 2006 Glutamate is the major excitatory neurotransmitter in brain, and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors (AMPARs) mediate the majority of postsynaptic depolarization. AMPAR ion channels display rapid gating, and their deactivation and desensitization determine the timing of synaptic transmission.
Susumu, Tomita +4 more
openaire +2 more sources
Neural Plasticity, Volume 2021, Issue 1, 2021., 2021 Synaptic activity mediates information storage and memory consolidation in the brain and requires a fast de novo synthesis of mRNAs in the nucleus and proteins in synapses. Intracellular localization of a protein can be achieved by mRNA trafficking and localized translation. Activity‐regulated cytoskeleton‐associated protein (Arc) is a master regulator
Michal Fila +5 more
wiley +1 more source
Molecular Mechanism of AMPA Receptor Modulation by TARP/Stargazin [PDF]
Neuron, 2017 AMPA receptors (AMPARs) mediate the majority of fast excitatory transmission in the brain and critically contribute to synaptic plasticity and pathology. AMPAR trafficking and gating are tightly controlled by auxiliary transmembrane AMPAR regulatory proteins (TARPs).
Anat, Ben-Yaacov +5 more
openaire +2 more sources
Calpain-mediated regulation of stargazin in adult rat brain [PDF]
Neuroscience, 2011 Changes in AMPA receptors have been proposed to underlie changes in synaptic efficacy in hippocampus and other brain structures. Calpain activation has also been discussed as a potential mechanism to produce lasting modifications of synaptic structure and function.
L, Yu +5 more
openaire +2 more sources
Screening for AMPA receptor auxiliary subunit specific modulators. [PDF]
PLoS ONE, 2017 AMPA receptors (AMPAR) are ligand gated ion channels critical for synaptic transmission and plasticity. Their dysfunction is implicated in a variety of psychiatric and neurological diseases ranging from major depressive disorder to amyotrophic lateral ...
Caleigh M Azumaya +6 more
doaj +1 more source
AMPA receptor GluA2 subunit defects are a cause of neurodevelopmental disorders [PDF]
, 2019 AMPA receptors (AMPARs) are tetrameric ligand-gated channels made up of combinations of GluA1-4 subunits encoded by GRIA1-4 genes. GluA2 has an especially important role because, following post-transcriptional editing at the Q607 site, it renders ...
al., et +3 more
core +24 more sources
Neurobiology of Disease, 2011 Absence-like seizures in the Genetic Absence Epilepsy Rats from Strasbourg (GAERS) model are believed to arise in hyperexcitable somatosensory cortical neurons, however the cellular basis of this increased excitability remains unknown. We have previously
J.T.T. Kennard +10 more
doaj +1 more source
Cells, 2022 The AMPA glutamate receptor (AMPAR) is the major type of synaptic excitatory ionotropic receptor in the brain. AMPARs have four different subunits, GluA1–4 (each encoded by different genes, Gria1, Gria2, Gria3 and Gria4), that can form distinct ...
Sophie J. F. van der Spek +7 more
doaj +1 more source
Aggregation Limits Surface Expression of Homomeric GluA3 Receptors [PDF]
, 2016 AMPA receptors are glutamate-gated cation channels assembled from GluA1-4 subunits and have properties that are strongly dependent on the subunit composition.
Ahmed +44 more
core +1 more source