Results 31 to 40 of about 2,711 (196)
The Stargazin C Terminus Encodes an Intrinsic and Transferable Membrane Sorting Signal [PDF]
Journal of Biological Chemistry, 2007 Activity-dependent plasticity of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors is regulated by their auxiliary subunit, stargazin. Association with stargazin enhances alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor surface expression and modifies the receptor's biophysical properties.
Matthew A. Bedoukian +4 more
openalex +4 more sources
Stargazin Reduces Desensitization and Slows Deactivation of the AMPA-Type Glutamate Receptors [PDF]
The Journal of Neuroscience, 2005 The AMPA-type glutamate receptors mediate the majority of the fast excitatory synaptic transmission and critically contribute to synaptic plasticity in the brain, hence the existence of numerous trafficking proteins dedicated to regulation of their synaptic delivery and turnover.
Avi Priel +5 more
openalex +6 more sources
S-nitrosylation of stargazin regulates surface expression of AMPA-glutamate neurotransmitter receptors [PDF]
Proceedings of the National Academy of Sciences, 2009 Synaptic plasticity is mediated by changes in the surface expression of AMPA receptors (AMPARs). Stargazin and related transmembrane AMPAR regulatory proteins have emerged as the principal regulators of AMPAR surface expression. Here, we show in heterologous cells and primary neurons that stargazin is physiologically S-nitrosylated, resulting in ...
B Selvakumar +2 more
openalex +5 more sources
The Interaction between Stargazin and PSD-95 Regulates AMPA Receptor Surface Trafficking [PDF]
Neuron, 2007 Accumulation of AMPA receptors at synapses is a fundamental feature of glutamatergic synaptic transmission. Stargazin, a member of the TARP family, is an AMPAR auxiliary subunit allowing interaction of the receptor with scaffold proteins of the postsynaptic density, such as PSD-95.
Cécile Bats +2 more
openalex +3 more sources
A new role for stargazin [PDF]
Nature Reviews Neuroscience, 2005 Rachel K. Jones
openalex +3 more sources
AMPA Receptor Modulation by Stargazin [PDF]
Biophysical Journal, 2017 Sana Shaikh +7 more
openalex +3 more sources
Aberrant hippocampal transmission and behavior in mice with a stargazin mutation linked to intellectual disability. [PDF]
Mol Psychiatry, 2022 Caldeira GL +14 more
europepmc +3 more sources
Genes, Brain and Behavior, Volume 22, Issue 6, December 2023., 2023 Variations in the Dlg2 gene have been linked to increased risk for psychiatric disorders. Here, we tested these predicted effects with a behavioural characterisation of the heterozygous Dlg2+/‐ rat model. Dlg2+/‐ rats exhibited a mild impairment in reversal learning but only in a substrate deterministic bowl‐digging reversal learning task.
Simonas Griesius +9 more
wiley +1 more source
A new perspective on hippocampal synaptic plasticity and post‐stroke depression
European Journal of Neuroscience, Volume 58, Issue 4, Page 2961-2984, August 2023., 2023 Abstract Post‐stroke depression, a common complication after stroke, severely affects the recovery and quality of life of patients with stroke. Owing to its complex mechanisms, post‐stroke depression treatment remains highly challenging. Hippocampal synaptic plasticity is one of the key factors leading to post‐stroke depression; however, the precise ...
Ning Sun +5 more
wiley +1 more source
Slow excitatory synaptic currents generated by AMPA receptors
The Journal of Physiology, Volume 600, Issue 2, Page 217-232, 15 January 2022., 2022 Abstract figure legend Besides their classical fast responses that depress with repeated stimulation (blue), some forms of AMPA‐type glutamate receptors can produce a current with slow kinetics approaching 0.5 s. A progressive increase in the current (‘pedestal’, orange) produces short‐term potentiation from a postsynaptic locus.
Niccolò P. Pampaloni +1 more
wiley +1 more source