Results 51 to 60 of about 1,323 (153)
LGI1 downregulation increases neuronal circuit excitability
Epilepsia, Volume 61, Issue 12, Page 2836-2846, December 2020., 2020 Abstract Objective Leucine‐rich glioma‐inactivated 1 (LGI1) is a secreted transsynaptic protein that interacts presynaptically with Kv1.1 potassium channels and a disintegrin and metalloprotease (ADAM) protein 23, and postsynaptically influences α‐amino‐3‐hydroxy‐5‐methylisoxazole‐4‐propionate receptors through a direct link with the ADAM22 cell ...
Eleonora Lugarà +6 more
wiley +1 more source
Stargazin promotes closure of the AMPA receptor ligand-binding domain [PDF]
Journal of General Physiology, 2014 Transmembrane AMPA receptor (AMPAR) regulatory proteins (TARPs) markedly enhance AMPAR function, altering ligand efficacy and receptor gating kinetics and thereby shaping the postsynaptic response. The structural mechanism underlying TARP effects on gating, however, is unknown.
Mei-mei Du +4 more
openaire +2 more sources
Learning to cope with stress modulates anterior cingulate cortex stargazin expression in monkeys and mice [PDF]
Neurobiology of Learning and Memory, 2016 Intermittent mildly stressful situations provide opportunities to learn, practice, and improve coping with gains in subsequent emotion regulation. Here we investigate the effects of learning to cope with stress on anterior cingulate cortex gene expression in monkeys and mice. Anterior cingulate cortex is involved in learning, memory, cognitive control,
Alex G. Lee +7 more
openalex +4 more sources
Auxiliary subunits keep AMPA receptors compact during activation and desensitization
eLife, 2018 Signal transduction at vertebrate excitatory synapses involves the rapid activation of AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole propionate) receptors, glutamate-gated ion channels whose four subunits assemble as a dimer-of-dimers.
Jelena Baranovic, Andrew JR Plested
doaj +1 more source
Frontiers in Cellular Neuroscience, 2013 Paradoxical seizure exacerbation by antiepileptic medication is a well-known clinical phenomenon in epilepsy, but the cellular mechanisms remain unclear.
Atul eMaheshwari +2 more
doaj +1 more source
S-nitrosylation of stargazin regulates surface expression of AMPA-glutamate neurotransmitter receptors [PDF]
Proceedings of the National Academy of Sciences, 2009 Synaptic plasticity is mediated by changes in the surface expression of AMPA receptors (AMPARs). Stargazin and related transmembrane AMPAR regulatory proteins have emerged as the principal regulators of AMPAR surface expression. Here, we show in heterologous cells and primary neurons that stargazin is physiologically S-nitrosylated, resulting in ...
B Selvakumar +2 more
openalex +5 more sources
Contribution of the Global Subunit Structure and Stargazin on the Maturation of AMPA Receptors [PDF]
The Journal of Neuroscience, 2010 Subunit assembly governs regulation of AMPA receptor (AMPA-R) synaptic delivery and determines biophysical parameters of the ion channel. However, little is known about the molecular pathways of this process. Here, we present single-particle EM three-dimensional structures of dimeric biosynthetic intermediates of the GluA2 subunit of AMPA-Rs ...
Anthony N. Farina +4 more
openaire +3 more sources
Superactivation of AMPA receptors by auxiliary proteins
Nature Communications, 2016 Transmembrane AMPA receptor regulatory proteins (TARPs) exert a number of effects on fast glutamatergic synaptic transmission. Here, the authors model the interactions of two such proteins, Stargazin and γ-8, and propose a simple kinetic mechanism by ...
Anna L. Carbone, Andrew J. R. Plested
doaj +1 more source
Structural properties and peptide ligand binding of the capsid homology domains of human Arc
Biochemistry and Biophysics Reports, 2021 The activity-regulated cytoskeleton-associated protein (Arc) is important for synaptic plasticity and the normal function of the brain. Arc interacts with neuronal postsynaptic proteins, but the mechanistic details of its function have not been fully ...
Erik I. Hallin +2 more
doaj
Metabolic etiologies in West syndrome
Epilepsia Open, Volume 3, Issue 2, Page 134-166, June 2018., 2018 Summary West syndrome (WS) is an early life epileptic encephalopathy associated with infantile spasms, interictal electroencephalography (EEG) abnormalities including high amplitude, disorganized background with multifocal epileptic spikes (hypsarrhythmia), and often neurodevelopmental impairments.
Seda Salar +2 more
wiley +1 more source