Results 51 to 60 of about 2,711 (196)

AMPA receptor GluA2 subunit defects are a cause of neurodevelopmental disorders [PDF]

, 2019
AMPA receptors (AMPARs) are tetrameric ligand-gated channels made up of combinations of GluA1-4 subunits encoded by GRIA1-4 genes. GluA2 has an especially important role because, following post-transcriptional editing at the Q607 site, it renders ...
al., et, Constantino, John N., Fassi, Emily, Shinawi, Marwan   +3 more
core   +22 more sources

Screening for AMPA receptor auxiliary subunit specific modulators. [PDF]

PLoS ONE, 2017
AMPA receptors (AMPAR) are ligand gated ion channels critical for synaptic transmission and plasticity. Their dysfunction is implicated in a variety of psychiatric and neurological diseases ranging from major depressive disorder to amyotrophic lateral ...
Caleigh M Azumaya, Emily L Days, Paige N Vinson, Shaun Stauffer, Gary Sulikowski, C David Weaver, Terunaga Nakagawa   +6 more
doaj   +1 more source

Stargazin and AMPA receptor membrane expression is increased in the somatosensory cortex of Genetic Absence Epilepsy Rats from Strasbourg

Neurobiology of Disease, 2011
Absence-like seizures in the Genetic Absence Epilepsy Rats from Strasbourg (GAERS) model are believed to arise in hyperexcitable somatosensory cortical neurons, however the cellular basis of this increased excitability remains unknown. We have previously
J.T.T. Kennard, R. Barmanray, S. Sampurno, E. Ozturk, C.A. Reid, L. Paradiso, G.M. D'Abaco, A.H. Kaye, S.J. Foote, T.J. O'Brien, K.L. Powell   +10 more
doaj   +1 more source

Expression and Interaction Proteomics of GluA1- and GluA3-Subunit-Containing AMPARs Reveal Distinct Protein Composition

Cells, 2022
The AMPA glutamate receptor (AMPAR) is the major type of synaptic excitatory ionotropic receptor in the brain. AMPARs have four different subunits, GluA1–4 (each encoded by different genes, Gria1, Gria2, Gria3 and Gria4), that can form distinct ...
Sophie J. F. van der Spek, Nikhil J. Pandya, Frank Koopmans, Iryna Paliukhovich, Roel C. van der Schors, Mylene Otten, August B. Smit, Ka Wan Li   +7 more
doaj   +1 more source

Pentraxins coordinate excitatory synapse maturation and circuit integration of parvalbumin interneurons [PDF]

, 2017
This is the author accepted manuscript. The final version is available from the publisher via the DOI in this record.Circuit computation requires precision in the timing, extent, and synchrony of principal cell (PC) firing that is largely enforced by ...
Barksdale, E, Cameron, HA, Chittajallu, R, Colonnese, MT, Craig, MT, Karlsson, R-M, McBain, CJ, Mitchell, RM, Murata, Y, Pelkey, KA, Petralia, RS, Sukumaran, M, Vargish, GA, Worley, PF, Wyeth, MS, Yuan, X   +15 more
core   +1 more source

Elucidation of AMPA receptor–stargazin complexes by cryo–electron microscopy [PDF]

Science, 2016
Stargazin and the AMPA receptor AMPA-subtype ionotropic glutamate receptors (AMPARs) mediate fast excitatory neurotransmission and contribute to higher cognitive processes such as learning and memory. In the brain, AMPARs exist as protein-protein complexes with various auxiliary subunits that tightly control AMPAR trafficking ...
Edward C. Twomey, Joachim Frank, Joachim Frank, Alexander I. Sobolevsky, Robert A. Grassucci, Maria V. Yelshanskaya   +5 more
openaire   +3 more sources

TARP γ-7 selectively enhances synaptic expression of calcium-permeable AMPARs [PDF]

, 2013
Regulation of calcium-permeable AMPA receptors (CP-AMPARs) is crucial in normal synaptic function and neurological disease states. Although transmembrane AMPAR regulatory proteins (TARPs) such as stargazin (γ-2) modulate the properties of calcium ...
A Priel, A Rozov, AC Jackson, AS Kato, AS Kato, B Liu, B Sommer, C Bats, C Bats, C Chung, CA Schneider, CH Cho, D Bowie, D Soto, D Soto, D Turetsky, D Yan, Dorota Studniarczyk, HY Man, Ian Coombs, J Mosbacher, J Schwenk, JJ Rosenthal, JR Geiger, JS Park, JT Isaac, K Hashimoto, K Menuz, KS Kim, L Cathala, L Chen, L Ferron, M Blaschke, M Fukaya, M Hollmann, M Koike, M Passafaro, M Yamazaki, MA Bedoukian, Mark Farrant, MS Washburn, N Burnashev, N Rouach, R Kuner, S Cull-Candy, S Kott, S Tomita, S Tomita, SF Traynelis, SF Traynelis, SJ Liu, SM Gardner, SN Kudoh, SQJ Liu, Stuart G Cull-Candy, V Gallo, V Gangadharan, VA Letts, Y Shi, Y Shi   +59 more
core   +1 more source

Synaptic Changes in AMPA Receptor Subunit Expression in Cortical Parvalbumin Interneurons in the Stargazer Model of Absence Epilepsy

Frontiers in Molecular Neuroscience, 2017
Feedforward inhibition is essential to prevent run away excitation within the brain. Recent evidence suggests that a loss of feed-forward inhibition in the corticothalamocortical circuitry may underlie some absence seizures.
Nadia K. Adotevi, Beulah Leitch
doaj   +1 more source

LGI1 downregulation increases neuronal circuit excitability

Epilepsia, Volume 61, Issue 12, Page 2836-2846, December 2020., 2020
Abstract Objective Leucine‐rich glioma‐inactivated 1 (LGI1) is a secreted transsynaptic protein that interacts presynaptically with Kv1.1 potassium channels and a disintegrin and metalloprotease (ADAM) protein 23, and postsynaptically influences α‐amino‐3‐hydroxy‐5‐methylisoxazole‐4‐propionate receptors through a direct link with the ADAM22 cell ...
Eleonora Lugarà, Rahul Kaushik, Marco Leite, Elodie Chabrol, Alexander Dityatev, Gabriele Lignani, Matthew C. Walker   +6 more
wiley   +1 more source

TARP γ-2 is required for inflammation-associated AMPA receptor plasticity within lamina II of the spinal cord dorsal horn [PDF]

, 2017
In the brain, transmembrane AMPA receptor (AMPAR) regulatory proteins (TARPs) critically influence the distribution, gating, and pharmacology of AMPARs, but the contribution of these auxiliary subunits to AMPAR-mediated signaling in the spinal cord ...
Cull-Candy, SG, Farrant, M, Sullivan, SJ
core   +1 more source