Results 51 to 60 of about 1,621 (161)
iScience, 2021 Summary: Postsynaptic density protein 95 is a key scaffolding protein in the postsynaptic density of excitatory glutamatergic neurons, organizing signaling complexes primarily via its three PSD-95/Discs-large/Zona occludens domains.
Maria Vistrup-Parry +10 more
doaj +1 more source
Evidence for association of bipolar disorder to haplotypes in the 22q12.3 region near the genes stargazin, ift27 and parvalbumin [PDF]
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 2012 Stephanie M. Nissen +3 more
semanticscholar +2 more sources
Genes, Brain and Behavior, Volume 22, Issue 6, December 2023., 2023 Variations in the Dlg2 gene have been linked to increased risk for psychiatric disorders. Here, we tested these predicted effects with a behavioural characterisation of the heterozygous Dlg2+/‐ rat model. Dlg2+/‐ rats exhibited a mild impairment in reversal learning but only in a substrate deterministic bowl‐digging reversal learning task.
Simonas Griesius +9 more
wiley +1 more source
Phenotypic heterogeneity in the stargazin allelic series [PDF]
Mammalian Genome, 2003 The stargazer mutant mouse is characterized by its ataxic gait, head tossing, and absence seizures. The mutation was identified in the gamma 2 subunit gene of the high voltage-dependent calcium channel, Cacng2. Subsequently, two allelic variants of stargazer have arisen, waggler and stargazer 3J. In this study, we have compared these new alleles to the
Letts, V A +6 more
openaire +3 more sources
A new perspective on hippocampal synaptic plasticity and post‐stroke depression
European Journal of Neuroscience, Volume 58, Issue 4, Page 2961-2984, August 2023., 2023 Abstract Post‐stroke depression, a common complication after stroke, severely affects the recovery and quality of life of patients with stroke. Owing to its complex mechanisms, post‐stroke depression treatment remains highly challenging. Hippocampal synaptic plasticity is one of the key factors leading to post‐stroke depression; however, the precise ...
Ning Sun +5 more
wiley +1 more source
Structural properties and peptide ligand binding of the capsid homology domains of human Arc
Biochemistry and Biophysics Reports, 2021 The activity-regulated cytoskeleton-associated protein (Arc) is important for synaptic plasticity and the normal function of the brain. Arc interacts with neuronal postsynaptic proteins, but the mechanistic details of its function have not been fully ...
Erik I. Hallin +2 more
doaj +1 more source
Slow excitatory synaptic currents generated by AMPA receptors
The Journal of Physiology, Volume 600, Issue 2, Page 217-232, 15 January 2022., 2022 Abstract figure legend Besides their classical fast responses that depress with repeated stimulation (blue), some forms of AMPA‐type glutamate receptors can produce a current with slow kinetics approaching 0.5 s. A progressive increase in the current (‘pedestal’, orange) produces short‐term potentiation from a postsynaptic locus.
Niccolò P. Pampaloni +1 more
wiley +1 more source
High-affinity anti-Arc nanobodies provide tools for structural and functional studies.
PLoS ONE, 2022 Activity-regulated cytoskeleton-associated protein (Arc) is a multidomain protein of retroviral origin with a vital role in the regulation of synaptic plasticity and memory formation in mammals.
Sigurbjörn Markússon +9 more
doaj +3 more sources
The Journal of Physiology, Volume 600, Issue 2, Page 201-215, 15 January 2022., 2022 Abstract figure legend Retinogeniculate synapses of the dLGN are large synapses with multiple release sites. Pronounced short‐term depression of currents in retinogeniculate synapses results from high release probability and desensitization of AMPA receptors.
Jakob von Engelhardt
wiley +1 more source
Journal of Cellular and Molecular Medicine, Volume 25, Issue 15, Page 7418-7425, August 2021., 2021 Abstract We previously showed a hydroxamic acid‐based histone deacetylase inhibitor (HDACi), compound 13, provides neuroprotection against chronic cerebral hypoperfusion (CCH) both in vitro under oxygen‐glucose deprivation (OGD) conditions and in vivo under bilateral common carotid artery occlusion (BCCAO) conditions.
Yao‐Ching Fang +7 more
wiley +1 more source