Results 51 to 60 of about 2,576 (168)

Paradoxical proepileptic response to NMDA receptor blockade linked to cortical interneuron defect in stargazer mice

Frontiers in Cellular Neuroscience, 2013
Paradoxical seizure exacerbation by antiepileptic medication is a well-known clinical phenomenon in epilepsy, but the cellular mechanisms remain unclear.
Atul eMaheshwari, Walter eNahm, Jeffrey eNoebels   +2 more
doaj   +1 more source

Glutamatergic neurons induce expression of functional glutamatergic synapses in primary myotubes. [PDF]

, 2012
The functioning of the nervous system depends upon the specificity of its synaptic contacts. The mechanisms triggering the expression of the appropriate receptors on postsynaptic membrane and the role of the presynaptic partner in the differentiation of ...
Baiguera C, Benarese M, Branca C, Buffelli M, Ettorre M, Laperchia C, Lorenzetto E, Pizzi M, Spano P   +8 more
core   +1 more source

AMPA Receptor Trafficking and the Control of Synaptic Transmission [PDF]

, 2001
Modificacions aprovades pel Plenari del Consell Municipal el 28-01 ...
Ajuntament de Barcelona, Gerència de Promoció Econòmica, Oficina de Management i Pressupost Executiu   +2 more
core   +1 more source

Stargazin promotes closure of the AMPA receptor ligand-binding domain [PDF]

Journal of General Physiology, 2014
Transmembrane AMPA receptor (AMPAR) regulatory proteins (TARPs) markedly enhance AMPAR function, altering ligand efficacy and receptor gating kinetics and thereby shaping the postsynaptic response. The structural mechanism underlying TARP effects on gating, however, is unknown.
MacLean, David M., Ramaswamy, Swarna S., Du, Mei, Howe, James R., Jayaraman, Vasanthi   +4 more
openaire   +2 more sources

A protein interaction based model for schizophrenia study [PDF]

, 2008
Background Schizophrenia is a complex disease with multiple factors contributing to its pathogenesis. In addition to environmental factors, genetic factors may also increase susceptibility.
Liu Chih-Min, Shih Kuan-Hui, Yang Ueng-Cheng, Hsu Pei-Chun, Liu Yu-Li, Hwu Hai-Gwo   +5 more
core   +2 more sources

Stargazin attenuates intracellular polyamine block of calcium-permeable AMPA receptors [PDF]

Nature Neuroscience, 2007
Endogenous polyamines profoundly affect the activity of various ion channels, including that of calcium-permeable AMPA-type glutamate receptors (CP-AMPARs). Here we show that stargazin, a transmembrane AMPAR regulatory protein (TARP) known to influence transport, gating and desensitization of AMPARs, greatly reduces block of CP-AMPARs by intracellular ...
David, Soto, Ian D, Coombs, Leah, Kelly, Mark, Farrant, Stuart G, Cull-Candy   +4 more
openaire   +2 more sources

Glutamatergic Reinnervation and Assembly of Glutamatergic Synapses in Adult Rat Skeletal Muscle Occurs at Cholinergic Endplates [PDF]

, 2009
After denervation of adult rat abdominal muscles, the postsynaptic apparatus of neuromuscular junctions (NMJs) retains its original architecture and clustering of acetylcholine receptors (AChRs).
A. BARBON, BAIGUERA C, BARLATI S, BORONI F, BRUNELLI G, BUFFELLI M, CAMBIANICA I, CLEMENTI F, ETTORRE M, FRANCOLINI M, GUARNERI B, LA VIA L, LANZILLOTTA A, PIZZI M, SPANO PF   +14 more
core   +1 more source

Human neuronal stargazin-like proteins, γ₂, γ₃ and γ₄; an investigation of their specific localization in human brain and their influence on Ca_V2.1 voltage-dependent calcium channels expressed in Xenopus oocytes.

BMC Neuroscience, 2003
Background Stargazin (γ2) and the closely related γ3, and γ4 transmembrane proteins are part of a family of proteins that may act as both neuronal voltage-dependent calcium channel (VDCC) γ subunits and transmembrane α-amino-3-hydroxy-5-methyl-4 ...
Dolphin Annette C, Moss Fraser J, Clare Jeffrey J   +2 more
doaj   +1 more source

PKC Anchoring to GluR4 AMPA Receptor Subunit Modulates PKC‐Driven Receptor Phosphorylation and Surface Expression [PDF]

, 2007
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/91156/1/j.1600-0854.2006.00521.x ...
Allison, Barria, Bayer, Boehm, Carvalho, Carvalho, Carvalho, Chen, Colbran, Coleman, Colledge, Condorelli, Correia, Duarte, Duarte, Esteban, Ghosh, Gomes, Grunder, Hayashi, Hayashi, Hoover, Kim, Kreimborg, Laemmli, Malenka, Malinow, Man, Nuriya, Passafaro, Ravindranathan, Rego, Rosenmund, Shen, Shi, Snyder, Song, Tomita, Tomita, Turetsky, Vandenberghe, Vandenberghe, Zhu   +42 more
core   +3 more sources

Auxiliary Subunit GSG1L Acts to Suppress Calcium-Permeable AMPA Receptor Function [PDF]

, 2015
UNLABELLED: AMPA-type glutamate receptors are ligand-gated cation channels responsible for a majority of the fast excitatory synaptic transmission in the brain.
Bats, C, Cull-Candy, SG, Farrant, M, McGee, TP   +3 more
core   +2 more sources