Results 71 to 80 of about 2,576 (168)
The synaptic vesicle cluster as a controller of pre‐ and postsynaptic structure and function
The Journal of Physiology, Volume 603, Issue 20, Page 5935-5964, October 15, 2025.Abstract figure legend The synaptic vesicle cluster acts as a master regulator of synaptic structure and function, through various involvements in processes that range from synaptic initiation to plasticity and synaptic loss. Abstract The synaptic vesicle cluster (SVC) is an essential component of chemical synapses, which provides neurotransmitter ...
Sofiia Reshetniak +35 more
wiley +1 more source
Metabolic etiologies in West syndrome
Epilepsia Open, Volume 3, Issue 2, Page 134-166, June 2018., 2018 Summary West syndrome (WS) is an early life epileptic encephalopathy associated with infantile spasms, interictal electroencephalography (EEG) abnormalities including high amplitude, disorganized background with multifocal epileptic spikes (hypsarrhythmia), and often neurodevelopmental impairments.
Seda Salar +2 more
wiley +1 more source
Human neuronal stargazin-like proteins, γ_2, γ_3 and γ_4; an investigation of their specific localization in human brain and their influence on Ca_V2.1 voltage-dependent calcium channels expressed in Xenopus oocytes [PDF]
, 2003 Background: Stargazin (γ2) and the closely related γ3, and γ4 transmembrane proteins are part of a family of proteins that may act as both neuronal voltage-dependent calcium channel (VDCC) γ subunits and transmembrane α-amino-3-hydroxy-5-methyl-4 ...
Clare, Jeffrey J. +2 more
core
Role for neonatal D-serine signaling: prevention of physiological and behavioral deficits in adult Pick1 knockout mice [PDF]
, 2016 NMDA glutamate receptors play key roles in brain development, function, and dysfunction. Regulatory roles of D-serine in NMDA receptor-mediated synaptic plasticity have been reported.
Jaaro Peled, Hanna +3 more
core +1 more source
Stargazin Modulates Native AMPA Receptor Functional Properties by Two Distinct Mechanisms [PDF]
The Journal of Neuroscience, 2005 AMPA receptors play a central role in basal excitatory synaptic transmission as well as synaptic maturation and plasticity. The transmembrane AMPA receptor regulatory protein (TARP) stargazin (γ2) serves multiple roles in trafficking and stabilizing synaptic AMPA receptors and may be incorporated as an auxiliary subunit.
Dorothy, Turetsky +2 more
openaire +2 more sources
Cell Proliferation, Volume 57, Issue 10, October 2024.This research uncovers a novel phosphorylation‐regulated phase separation property of SDC4 on the PM by which SDC4 realizes efficient recruitment of cytosolic syntenin and thereby facilitates the biogenesis of exosomes, providing potential intervention targets for exosome‐involved biomedical events. Abstract The biogenesis of exosomes that mediate cell‐
Tian Zhao +6 more
wiley +1 more source
Emerging Synaptic Molecules as Candidates in the Etiology of Neurological Disorders
Neural Plasticity, Volume 2017, Issue 1, 2017., 2017 Synapses are complex structures that allow communication between neurons in the central nervous system. Studies conducted in vertebrate and invertebrate models have contributed to the knowledge of the function of synaptic proteins. The functional synapse requires numerous protein complexes with specialized functions that are regulated in space and time
Viviana I. Torres +3 more
wiley +1 more source
Proteomic Analysis of Postsynaptic Protein Complexes Underlying Neuronal Plasticity [PDF]
, 2017 Normal neuronal communication and synaptic plasticity at glutamatergic synapses requires dynamic regulation of postsynaptic molecules. Protein expression and protein post-translational modifications regulate protein interactions that underlie this ...
Baucum, Anthony J., II
core +1 more source
Reconstitution of invertebrate glutamate receptor function depends on stargazin-like proteins [PDF]
Proceedings of the National Academy of Sciences, 2006 α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors (AMPARs) are a major subtype of ionotropic glutamate receptors (iGluRs) that mediate rapid excitatory synaptic transmission in the vertebrate brain. Putative AMPARs are also expressed in the nervous system of invertebrates.
Craig S, Walker +8 more
openaire +2 more sources
Ibrain, Volume 10, Issue 3, Page 323-344, Fall 2024.Based on R, immune infiltration analysis found that normal and disease immune cells expressed differently, weighted gene co‐expression network analysis determined the key genes of diseases and clustering, and eXtreme Gradient Boosting model screened Hub genes. Abstract This study aims to explore the expression profile of PANoptosis‐related genes (PRGs)
Jin‐Lin Mei +5 more
wiley +1 more source