Results 71 to 80 of about 2,711 (196)

Contribution of the Global Subunit Structure and Stargazin on the Maturation of AMPA Receptors [PDF]

The Journal of Neuroscience, 2010
Subunit assembly governs regulation of AMPA receptor (AMPA-R) synaptic delivery and determines biophysical parameters of the ion channel. However, little is known about the molecular pathways of this process. Here, we present single-particle EM three-dimensional structures of dimeric biosynthetic intermediates of the GluA2 subunit of AMPA-Rs ...
Anthony N. Farina, Tomohiko Maruo, Mark H. Ellisman, Terunaga Nakagawa, Natalie F. Shanks   +4 more
openaire   +3 more sources

PKC Anchoring to GluR4 AMPA Receptor Subunit Modulates PKC‐Driven Receptor Phosphorylation and Surface Expression [PDF]

, 2007
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/91156/1/j.1600-0854.2006.00521.x ...
Allison, Barria, Bayer, Boehm, Carvalho, Carvalho, Carvalho, Chen, Colbran, Coleman, Colledge, Condorelli, Correia, Duarte, Duarte, Esteban, Ghosh, Gomes, Grunder, Hayashi, Hayashi, Hoover, Kim, Kreimborg, Laemmli, Malenka, Malinow, Man, Nuriya, Passafaro, Ravindranathan, Rego, Rosenmund, Shen, Shi, Snyder, Song, Tomita, Tomita, Turetsky, Vandenberghe, Vandenberghe, Zhu   +42 more
core   +3 more sources

Role for neonatal D-serine signaling: prevention of physiological and behavioral deficits in adult Pick1 knockout mice [PDF]

, 2016
NMDA glutamate receptors play key roles in brain development, function, and dysfunction. Regulatory roles of D-serine in NMDA receptor-mediated synaptic plasticity have been reported.
Jaaro Peled, Hanna, Lewis, Eastman, Nomura, Jun, Núñez Abades, Pedro Antonio   +3 more
core   +1 more source

Metabolic etiologies in West syndrome

Epilepsia Open, Volume 3, Issue 2, Page 134-166, June 2018., 2018
Summary West syndrome (WS) is an early life epileptic encephalopathy associated with infantile spasms, interictal electroencephalography (EEG) abnormalities including high amplitude, disorganized background with multifocal epileptic spikes (hypsarrhythmia), and often neurodevelopmental impairments.
Seda Salar, Solomon L. Moshé, Aristea S. Galanopoulou   +2 more
wiley   +1 more source

Global Scaling Down of Excitatory Postsynaptic Responses in Cerebellar Purkinje Cells Impairs Developmental Synapse Elimination

Cell Reports, 2014
Synapse elimination is crucial for precise neural circuit formation during postnatal development. We examined how relative differences in synaptic strengths among competing inputs and/or absolute synaptic strengths contribute to climbing fiber (CF) to ...
Shinya Kawata, Taisuke Miyazaki, Maya Yamazaki, Takayasu Mikuni, Miwako Yamasaki, Kouichi Hashimoto, Masahiko Watanabe, Kenji Sakimura, Masanobu Kano   +8 more
doaj   +1 more source

Human neuronal stargazin-like proteins, gamma(2), gamma(3) and gamma(4); an investigation of their specific localization in human brain and their influence on Ca(V)2.1 voltage-dependent calcium channels expressed in Xenopus oocytes [PDF]

, 2003
Background: Stargazin (gamma(2)) and the closely related gamma(3), and gamma(4) transmembrane proteins are part of a family of proteins that may act as both neuronal voltage-dependent calcium channel (VDCC) gamma subunits and transmembrane alpha-amino-3 ...
Clare, JJ, Dolphin, AC, Moss, FJ
core  

Dual Effects of TARP γ-2 on Glutamate Efficacy Can Account for AMPA Receptor Autoinactivation [PDF]

, 2017
Fast excitatory transmission in the CNS is mediated mainly by AMPA-type glutamate receptors (AMPARs) associated with transmembrane AMPAR regulatory proteins (TARPs).
Coombs, ID, Cull-Candy, SG, Farrant, M, Jayaraman, V, MacLean, DM   +4 more
core   +2 more sources

Phosphorylation‐regulated phase separation of syndecan‐4 and syntenin promotes the biogenesis of exosomes

Cell Proliferation, Volume 57, Issue 10, October 2024.
This research uncovers a novel phosphorylation‐regulated phase separation property of SDC4 on the PM by which SDC4 realizes efficient recruitment of cytosolic syntenin and thereby facilitates the biogenesis of exosomes, providing potential intervention targets for exosome‐involved biomedical events. Abstract The biogenesis of exosomes that mediate cell‐
Tian Zhao, Xiaolan Yang, Guangfei Duan, Jialin Chen, Kefeng He, Yong‐Xiang Chen, Shi‐Zhong Luo   +6 more
wiley   +1 more source

Emerging Synaptic Molecules as Candidates in the Etiology of Neurological Disorders

Neural Plasticity, Volume 2017, Issue 1, 2017., 2017
Synapses are complex structures that allow communication between neurons in the central nervous system. Studies conducted in vertebrate and invertebrate models have contributed to the knowledge of the function of synaptic proteins. The functional synapse requires numerous protein complexes with specialized functions that are regulated in space and time
Viviana I. Torres, Daniela Vallejo, Nibaldo C. Inestrosa, Tiziana Borsello   +3 more
wiley   +1 more source

The Stargazin-Related Protein {gamma}7 Interacts with the mRNA-Binding Protein Heterogeneous Nuclear Ribonucleoprotein A2 and Regulates the Stability of Specific mRNAs, Including CaV2.2 [PDF]

, 2008
The role(s) of the novel stargazin-like {gamma}-subunit proteins remain controversial. We have shown previously that the neuron-specific {gamma}7 suppresses the expression of certain calcium channels, particularly CaV2.2, and is therefore unlikely to ...
Bolsover, Steven, Butcher, Adrian J., Cox, David J., Davies, Anthony, Dolphin, Annette C., Ferron, Laurent, Leroy, Jerôme, Moss, Fraser J., Page, Karen M., Pratt, Wendy S., Sellaturay, Priya, Waithe, Dominic   +11 more
core   +1 more source