LGI proteins in the nervous system [PDF]
, 2013 The development and function of the vertebrate nervous system depend on specific interactions between different cell types. Two examples of such interactions are synaptic transmission and myelination.
Aunin, E. (Eerik) +3 more
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Advances in understanding the pathogenesis of epilepsy: Unraveling the molecular mechanisms
Health Science Reports, Volume 7, Issue 2, February 2024.Abstract Introduction Epilepsy is characterized by having two or more unprovoked seizures. Understanding the pathogenesis of epilepsy, requires deep investigation into the molecular mechanisms. This helps develop diagnostic techniques, treatments, and pharmacotherapy. It also enhances precision medicine and individualized treatment processes.
Sanobar Shariff +7 more
wiley +1 more source
Glutamat-Rezeptoren und synaptische Plastizität in der lateralen Amygdala [PDF]
, 2019 Synaptische Plastizität an zentralen Synapsen gilt als grundlegender Mechanismus für Lernen und Gedächtnis. Die Amygdala ist für das Furchtgedächtnis von besonderer Bedeutung.
Gebhardt, Christine
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Epilepsia, Volume 65, Issue 2, Page e20-e26, February 2024.Abstract The transmembrane α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid receptor (AMPAR) regulatory proteins (TARPs), γ2 (stargazin), γ3, γ4, γ5, γ7, and γ8, are a family of proteins that regulate AMPAR trafficking, expression, and biophysical properties that could have a role in the development of absence seizures.
Pablo M. Casillas‐Espinosa +4 more
wiley +1 more source
A Myosin Va Mutant Mouse with Disruptions in Glutamate Synaptic Development and Mature Plasticity in Visual Cortex [PDF]
, 2017 Myosin Va (MyoVa) mediates F-actin-based vesicular transport toward the plasma membrane and is found at neuronal postsynaptic densities (PSDs), but the role of MyoVa in synaptic development and function is largely unknown.
Constantine-Paton, Martha +4 more
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Stargazin Reduces Desensitization and Slows Deactivation of the AMPA-Type Glutamate Receptors [PDF]
The Journal of Neuroscience, 2005 The AMPA-type glutamate receptors mediate the majority of the fast excitatory synaptic transmission and critically contribute to synaptic plasticity in the brain, hence the existence of numerous trafficking proteins dedicated to regulation of their synaptic delivery and turnover.
Priel, A. +5 more
openaire +3 more sources
Postsynaptic protein organization revealed by electron microscopy. [PDF]
, 2019 Neuronal synapses are key devices for transmitting and processing information in the nervous system. Synaptic plasticity, generally regarded as the cellular basis of learning and memory, involves changes of subcellular structures that take place at the ...
Bi, Guo-Qiang +4 more
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Molecular mechanisms contributing to TARP regulation of channel conductance and polyamine block of calcium-permeable AMPA receptors. [PDF]
, 2018 Many properties of fast synaptic transmission in the brain are influenced by transmembrane AMPAR regulatory proteins (TARPs) that modulate the pharmacology and gating of AMPA-type glutamate receptors (AMPARs).
Coombs, Ian D. +4 more
core +1 more source
The Stargazin C Terminus Encodes an Intrinsic and Transferable Membrane Sorting Signal [PDF]
Journal of Biological Chemistry, 2008 Activity-dependent plasticity of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors is regulated by their auxiliary subunit, stargazin. Association with stargazin enhances alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor surface expression and modifies the receptor's biophysical properties.
Matthew A, Bedoukian +4 more
openaire +2 more sources
A study of the molecular basis of the interaction between AMPARs and their auxiliary subunits [PDF]
, 2015 AMPA receptors (AMPARs) are crucial for fast excitatory synaptic transmission throughout the mammalian central nervous system (CNS). At the molecular level, these receptors are tetramers of GluA1-4 subunits, which can be homomeric or heteromeric ...
Krol, KA
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