Results 81 to 90 of about 2,711 (196)

Molecular mechanisms contributing to TARP regulation of channel conductance and polyamine block of calcium-permeable AMPA receptors. [PDF]

, 2018
Many properties of fast synaptic transmission in the brain are influenced by transmembrane AMPAR regulatory proteins (TARPs) that modulate the pharmacology and gating of AMPA-type glutamate receptors (AMPARs).
Coombs, Ian D., Cull-Candy, Stuart G., Farrant, Mark, Gratacòs i Batlle, Esther, Soto del Cerro, David   +4 more
core   +1 more source

Identification of immune infiltration and PANoptosis‐related molecular clusters and predictive model in Alzheimer's disease based on transcriptome analysis

Ibrain, Volume 10, Issue 3, Page 323-344, Fall 2024.
Based on R, immune infiltration analysis found that normal and disease immune cells expressed differently, weighted gene co‐expression network analysis determined the key genes of diseases and clustering, and eXtreme Gradient Boosting model screened Hub genes. Abstract This study aims to explore the expression profile of PANoptosis‐related genes (PRGs)
Jin‐Lin Mei, Shi‐Feng Wang, Yang‐Yang Zhao, Ting Xu, Yong Luo, Liu‐Lin Xiong   +5 more
wiley   +1 more source

Amyloid‐β‐Induced Dysregulation of AMPA Receptor Trafficking

Neural Plasticity, Volume 2016, Issue 1, 2016., 2016
Evidence from neuropathological, genetic, animal model, and biochemical studies has indicated that the accumulation of amyloid‐beta (Aβ) is associated with, and probably induces, profound neuronal changes in brain regions critical for memory and cognition in the development of Alzheimer’s disease (AD).
Sumasri Guntupalli, Jocelyn Widagdo, Victor Anggono, Long-Jun Wu   +3 more
wiley   +1 more source

Advances in understanding the pathogenesis of epilepsy: Unraveling the molecular mechanisms

Health Science Reports, Volume 7, Issue 2, February 2024.
Abstract Introduction Epilepsy is characterized by having two or more unprovoked seizures. Understanding the pathogenesis of epilepsy, requires deep investigation into the molecular mechanisms. This helps develop diagnostic techniques, treatments, and pharmacotherapy. It also enhances precision medicine and individualized treatment processes.
Sanobar Shariff, Halah A. Nouh, Samuel Inshutiyimana, Charbel Kachouh, Maya M. Abdelwahab, Abubakar Nazir, Magda Wojtara, Olivier Uwishema   +7 more
wiley   +1 more source

Nitric Oxide‐Mediated Posttranslational Modifications: Impacts at the Synapse

Oxidative Medicine and Cellular Longevity, Volume 2016, Issue 1, 2016., 2016
Nitric oxide (NO) is an important gasotransmitter molecule that is involved in numerous physiological processes throughout the nervous system. In addition to its involvement in physiological plasticity processes (long‐term potentiation, LTP; long‐term depression, LTD) which can include NMDAR‐mediated calcium‐dependent activation of neuronal nitric ...
Sophie A. Bradley, Joern R. Steinert, Vittorio Calabrese   +2 more
wiley   +1 more source

Human neuronal stargazin-like proteins, γ_2, γ_3 and γ_4; an investigation of their specific localization in human brain and their influence on Ca_V2.1 voltage-dependent calcium channels expressed in Xenopus oocytes [PDF]

, 2003
Background: Stargazin (γ2) and the closely related γ3, and γ4 transmembrane proteins are part of a family of proteins that may act as both neuronal voltage-dependent calcium channel (VDCC) γ subunits and transmembrane α-amino-3-hydroxy-5-methyl-4 ...
Clare, Jeffrey J., Dolphin, Annette C., Moss, Fraser J.   +2 more
core  

LGI proteins in the nervous system [PDF]

, 2013
The development and function of the vertebrate nervous system depend on specific interactions between different cell types. Two examples of such interactions are synaptic transmission and myelination.
Aunin, E. (Eerik), Bermingham Jr, J.R. (John), Kegel, L. (Linde), Meijer, D.N. (Dies)   +3 more
core   +4 more sources

Transmembrane α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid receptor regulatory protein expression during the development of absence seizures in genetic absence epilepsy rats from Strasbourg

Epilepsia, Volume 65, Issue 2, Page e20-e26, February 2024.
Abstract The transmembrane α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid receptor (AMPAR) regulatory proteins (TARPs), γ2 (stargazin), γ3, γ4, γ5, γ7, and γ8, are a family of proteins that regulate AMPAR trafficking, expression, and biophysical properties that could have a role in the development of absence seizures.
Pablo M. Casillas‐Espinosa, Runxuan Lin, Rui Li, Kim L. Powell, Terence J. O'Brien   +4 more
wiley   +1 more source

D‐Amino Acids in the Nervous and Endocrine Systems

Scientifica, Volume 2016, Issue 1, 2016., 2016
Amino acids are important components for peptides and proteins and act as signal transmitters. Only L‐amino acids have been considered necessary in mammals, including humans. However, diverse D‐amino acids, such as D‐serine, D‐aspartate, D‐alanine, and D‐cysteine, are found in mammals.
Yoshimitsu Kiriyama, Hiromi Nochi, Mirko Diksic   +2 more
wiley   +1 more source

PSD-95-like membrane associated guanylate kinases (PSD-MAGUKs) and synaptic plasticity [PDF]

, 2011
Activity-dependent modification of excitatory synaptic transmission is a fundamental mechanism for developmental plasticity of the neural circuits and experience-dependent plasticity.
Xu, Weifeng
core   +1 more source