Results 1 to 10 of about 250,824 (344)

Effect of leptin on the growth and expression of STAT3 in yak mammary epithelial cells [PDF]

Veterinary World, 2022
Background and Aim: Leptin (LEP) is an autocrine and paracrine factor produced by the fat pad and acinar epithelial cells of the breast. This study aimed to investigate the effects of LEP on yak mammary epithelial cells (YMECs) and the expression of ...
Baoxia Dong, Sidra Mehran, Yuying Yang, Haixia Jing, Lin Liang, Xiaoyu Guo, Qinwen Zhang   +6 more
doaj   +1 more source

The role of IL-6/JAK2/STAT3 signaling pathway in cancers

Frontiers in Oncology, 2022
Interleukin-6 (IL-6) is a pleiotropic cytokine involved in immune regulation. It can activate janus kinase 2 (JAK2)-signal transducer and activator of transcription 3 (STAT3) signaling pathway.
B. Huang, Xiaoling Lang, Xihong Li
semanticscholar   +1 more source

Advances in the role of STAT3 in macrophage polarization

Frontiers in Immunology, 2023
The physiological processes of cell growth, proliferation, differentiation, and apoptosis are closely related to STAT3, and it has been demonstrated that aberrant STAT3 expression has an impact on the onset and progression of a number of inflammatory ...
T. Xia, Meng Zhang, Wei Lei, Ruilin Yang, Shen-ao Fu, Zhenhai Fan, Ying Yang, Tao Zhang   +7 more
semanticscholar   +1 more source

The Role of Transcription Factors in Coronary Artery Disease and Myocardial Infarction

Frontiers in Bioscience-Landmark, 2022
Coronary artery disease (CAD) and its main complication, myocardial infarction (MI), is a complex disease caused by environmental and genetic factors and their interaction.
Chunyan Luo, Yuwen Ruan, Peixue Sun, Haoran Wang, Weihua Yang, Yuankai Gong, Decheng Wang   +6 more
doaj   +1 more source

MiR-199a-5p–HIF-1α-STAT3 Positive Feedback Loop Contributes to the Progression of Non-Small Cell Lung Cancer

Frontiers in Cell and Developmental Biology, 2021
Background: Non-small cell lung cancer (NSCLC) is the most common malignancy worldwide. MiR-199a-5p has been reported to play important roles in multiple tumors, inclusive of NSCLC.
Xingping Yang, Yuzhen Zheng, Jian Tan, Renjiang Tian, Piao Shen, Weijie Cai, Hongying Liao   +6 more
doaj   +1 more source

Novel STAT3 Inhibitors Targeting STAT3 Dimerization by Binding to the STAT3 SH2 Domain

Frontiers in Pharmacology, 2022
Our drug discovery model has identified two novel STAT3 SH2 domain inhibitors 323–1 and 323–2 (delavatine A stereoisomers) in a series of experiments. In silico computational modeling, drug affinity responsive target stability (DARTS), and fluorescence polarization (FP) assays altogether determined that 323–1 and 323–2 directly target the STAT3 SH2 ...
Yaping Hua, Xing Yuan, Yun-heng Shen, Jinxin Wang, Waqas Azeem, Waqas Azeem, Waqas Azeem, Shuo Yang, Alexandra Gade, Seyed Mohammad Lellahi, Anne Margrete Øyan, Anne Margrete Øyan, Anne Margrete Øyan, Xisong Ke, Xisong Ke, Wei-dong Zhang, Wei-dong Zhang, Karl-Henning Kalland, Karl-Henning Kalland, Karl-Henning Kalland   +19 more
openaire   +6 more sources

Role of JAK2/STAT3 Signaling Pathway in the Tumorigenesis, Chemotherapy Resistance, and Treatment of Solid Tumors: A Systemic Review

Journal of Inflammation Research, 2022
Janus kinase 2/signal transducer and activator of transcription 3 (JAK2/STAT3) pathway is a common signaling pathway used to transduce signals from the extracellular to the intracellular (nucleus) upon the binding of cytokines and growth factors to the ...
Teklie Mengie Ayele, Zelalem Tilahun Muche, Awgichew Behaile Teklemariam, Achenef Bogale Kassie, Endeshaw Chekol Abebe   +4 more
semanticscholar   +1 more source

RBM8A Promotes Glioblastoma Growth and Invasion Through the Notch/STAT3 Pathway

Frontiers in Oncology, 2021
BackgroundGlioblastoma (GBM) is a prevalent brain malignancy with an extremely poor prognosis, which is attributable to its invasive biological behavior. The RNA-binding motif protein 8A (RBM8A) has different effects on various human cancers.
Yan Lin, Lei Wei, Beiquan Hu, Jinyan Zhang, Jiazhang Wei, Zhongrun Qian, Donghua Zou   +6 more
doaj   +1 more source

Janus Kinase Inhibition Ameliorates Ischemic Stroke Injury and Neuroinflammation Through Reducing NLRP3 Inflammasome Activation via JAK2/STAT3 Pathway Inhibition

Frontiers in Immunology, 2021
Background Inflammatory responses play a multiphase role in the pathogenesis of cerebral ischemic stroke (IS). Ruxolitinib (Rux), a selective oral JAK 1/2 inhibitor, reduces inflammatory responses via the JAK2/STAT3 pathway.
Hua Zhu, Z. Jian, Yi Zhong, Yingze Ye, Yonggang Zhang, Xinyao Hu, Bei Pu, Lijuan Gu, X. Xiong   +8 more
semanticscholar   +1 more source

Anti-melanoma SK-Mel-103 cells effect of a natural small molecule, HEP-14

陆军军医大学学报, 2022
Objective To investigate the inhibitory effect of a natural small molecule, HEP-14, on melanoma SK-Mel-103 cells and its underlying mechanism. Methods SK-Mel-103 cells were treated with HEP-14 at different concentrations (2.5~40 μmol/L).
LIU Fang, LIU Fang, ZHONG Qin, ZHONG Qin, WANG Xia, WANG Xia   +5 more
doaj   +1 more source