Results 1 to 10 of about 179,101 (246)
Gut and Liver, 2021 Background/Aims: Interleukin-22 (IL-22) is an important cytokine maintaining homeostasis at barrier surfaces. In this study, the role of IL-22 in acute pancreatitis-associated intestinal injury was further explored.
Jinxia Bai, Jinyun Bai, Meng Yang
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Frontiers in Pharmacology, 2022 Gastric cancer is a common malignant tumor that threatens human health, and its occurrence and development mechanism is a complex process involving multiple genes and multiple signals.
Haobin Li +14 more
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Novel STAT3 Inhibitors Targeting STAT3 Dimerization by Binding to the STAT3 SH2 Domain
Frontiers in Pharmacology, 2022 Our drug discovery model has identified two novel STAT3 SH2 domain inhibitors 323–1 and 323–2 (delavatine A stereoisomers) in a series of experiments. In silico computational modeling, drug affinity responsive target stability (DARTS), and fluorescence polarization (FP) assays altogether determined that 323–1 and 323–2 directly target the STAT3 SH2 ...
Yaping Hua +19 more
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Effect of leptin on the growth and expression of STAT3 in yak mammary epithelial cells [PDF]
Veterinary World, 2022 Background and Aim: Leptin (LEP) is an autocrine and paracrine factor produced by the fat pad and acinar epithelial cells of the breast. This study aimed to investigate the effects of LEP on yak mammary epithelial cells (YMECs) and the expression of ...
Baoxia Dong +6 more
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STAT3: A multifaceted oncogene [PDF]
Proceedings of the National Academy of Sciences, 2006 Signal transducers and activators of transcription (STAT) proteins are a family of transcription factors first characterized for their role in cytokine signaling. These versatile proteins contain a site for specific tyrosine phosphorylation, a modification that results in a conformational rearrangement and dimerization through phosphotyrosine–SH2 ...
D. E. LEVY, INGHIRAMI, Giorgio
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The effect of high-intensity interval training on IL-22 and STAT3 gene expression of liver tissue in steatosis animal model [PDF]
Journal of Exercise & Organ Cross Talk, 2023 Inflammation is a major component of almost all acute and chronic liver disorders, including non-alcoholic fatty liver disease. This study aimed to investigate the effect of high-intensity interval training on IL-22 and STAT3 gene expression of liver ...
Vahideh Ebrahimi Gharab +3 more
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Dihydrotanshinone Inhibits Hepatocellular Carcinoma by Suppressing the JAK2/STAT3 Pathway
Frontiers in Pharmacology, 2021 Liver cancer is the sixth most commonly diagnosed cancer and the fourth leading cause of cancer death. Most (75–85%) primary liver cancers occurring worldwide are hepatocellular carcinoma (HCC).
Xue Hu +3 more
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Membrane-associated STAT3 and PY-STAT3 in the Cytoplasm [PDF]
Journal of Biological Chemistry, 2006 Signal transduction from the plasma membrane to the nucleus by STAT proteins is widely represented as exclusively a soluble cytosolic process. Using cell-fractionation methods, we observed that approximately 5% of cytoplasmic STAT3 was constitutively associated with the purified early endosome (EE) fraction in human Hep3B liver cells.
Mehul, Shah +5 more
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Frontiers in Nutrition, 2021 It is known that lipopolysaccharide (LPS) triggers inflammatory response after intracerebroventricular (ICV) injection and elevates the expression of hepcidin through the interleukin 6/janus kinase 2/transducer and activator of the transcription 3 (IL-6 ...
Fali Zhang +4 more
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STAT3 Mutation Is Associated with STAT3 Activation in CD30+ ALK− ALCL [PDF]
Cancers, 2020 Peripheral T-cell lymphomas (PTCL) are a heterogeneous, and often aggressive group of non-Hodgkin lymphomas. Recent advances in the molecular and genetic characterization of PTCLs have helped to delineate differences and similarities between the various subtypes, and the JAK/STAT pathway has been found to play an important oncogenic role.
Emma I. Andersson +10 more
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