Results 11 to 20 of about 308,589 (291)

Epidermal growth factor receptor and STAT3 signal through KRAS have mutually opposite effects on CTEN

Journal of Biochemical and Clinical Genetics, 2021
Background: C-terminal tensin-like (CTEN) is a protein located at focal adhesions and has been reported to be an oncogene in the colon, breast, lung, and gastric cancer.
Saleh AlGhamdi, Salih Ibrahim, Kanwal Balloch, Darryl Jackson, Mohammad Ilyas   +4 more
doaj   +1 more source

Erythropoietin-induced serine 727 phosphorylation of STAT3 in erythroid cells is mediated by a MEK-, ERK-, and MSK1-dependent pathway [PDF]

, 2003
Objective. Erythropoietin (EPO) is a key regulator of erythropoiesis, playing a role in both the proliferation and differentiation of erythroid cells.
Bieber, Boer, Chung, Decker, Gabrilove, Gonzalez, Goodnough, Gotoh, Haq, Jain, Jain, Jonk, Kaptein, Kirito, Kirito, Kirito, Lim, Millot, Miyazaki, Mulcahy, Ng, Schuringa, Schuringa, Schuringa, Smithgall, Socolovsky, Teglund, Tilbrook, Turkson, Watowich, Wen, Wen, Woetmann, Yokogami, Youssoufian, Yu, Zhang   +36 more
core   +1 more source

Administration of low-dose resveratrol attenuated hepatic inflammation and lipid accumulation in high cholesterol-fructose diet-induced rat model of nonalcoholic fatty liver disease

Chinese Journal of Physiology, 2020
Resveratrol (RSV) has been demonstrated to ameliorate nonalcoholic fatty liver disease (NAFLD) in animal studies. However, RSV was given with the dosage that ranged from 7 to 300 mg/kg body weight (BW).
Chih-Chun Chang, Chieh-Yu Chang, Pei-Chun Lin, Jiung-Pang Huang, Kuan-Hsing Chen, Tzung-Hai Yen, Li-Man Hung   +6 more
doaj   +1 more source

Synergistic Activity of the HSP90 Inhibitor Ganetespib With Lapatinib Reverses Acquired Lapatinib Resistance in HER2-Positive Breast Cancer Cells

Frontiers in Pharmacology, 2021
Lapatinib is an FDA-approved EGFR and HER2 tyrosine kinase inhibitor for the treatment of HER2-positive breast cancer patients. However, its therapeutic efficacy is limited by primary or acquired resistance.
Min Ye, Min Ye, Wei Huang, Wei Huang, Rui Liu, Yingli Kong, Yang Liu, Yang Liu, Xiaole Chen, Xiaole Chen, Jianhua Xu, Jianhua Xu   +11 more
doaj   +1 more source

Signal transduction and activator of transcription-3 (STAT3) in patients with colorectal cancer: associations with the phenotypic features of the tumour and host [PDF]

, 2017
Purpose: In patients with colorectal cancer (CRC), a high-density local inflammatory infiltrate response is associated with improved survival, whereas elevated systemic inflammatory responses are associated with poor survival.
Clark, Jennifer, Edwards, Joanne, Horgan, Paul G., McMillan, Donald C., Park, James H., Quinn, Jean A., Roxburgh, Campbell, Van Wyk, Hester C.   +7 more
core   +1 more source

Progestins induce transcriptional activation of signal transducer and activator of transcription 3 (Stat3) via a Jak- and Src-dependent mechanism in breast cancer cells [PDF]

, 2005
Interactions between steroid hormone receptors and signal transducer and activator of transcription (Stat)-mediated signaling pathways have already been described.
Carnevale, Romina Paula, Charreau, Eduardo Hernan, Elizalde, Patricia Virginia, Frahm, Isabel, Kornblihtt, Alberto Rodolfo, Molinolo, Alfredo, Pecci, Adali, Proietti Anastasi, Cecilia Jazmín, Rosemblit, Cinthia, Salatino, Mariana, Schillaci, Roxana   +10 more
core   +3 more sources

The Stat3-Fam3a axis promotes muscle stem cell myogenic lineage progression by inducing mitochondrial respiration. [PDF]

, 2019
Metabolic reprogramming is an active regulator of stem cell fate choices, and successful stem cell differentiation in different compartments requires the induction of oxidative phosphorylation.
Cunningham, Thomas J, Dall'Agnese, Alessandra, Duester, Gregg, Etxaniz, Usue, Latella, Lucia, Nicoletti, Chiara, Puri, Pier Lorenzo, Sacco, Alessandra, Sala, David, Stec, Michael J   +9 more
core   +3 more sources

Tfh Exosomes Derived from Allergic Rhinitis Promote DC Maturation Through miR-142-5p/CDK5/STAT3 Pathway

Journal of Inflammation Research, 2022
Zhen-Xiao Teng,1,* Xuan-Chen Zhou,2,* Run-Tong Xu,2 Fang-Yuan Zhu,2 Xin Bing,1 Na Guo,2 Lei Shi,2 Wen-Wen Qi,1 Cheng-Cheng Liu,3 Ming Xia1,2 1Department of Otolaryngology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong ...
Teng ZX, Zhou XC, Xu RT, Zhu FY, Bing X, Guo N, Shi L, Qi WW, Liu CC, Xia M   +9 more
doaj  

Genetic partitioning of interleukin-6 signalling in mice dissociates Stat3 from Smad3-mediated lung fibrosis [PDF]

, 2012
Idiopathic pulmonary fibrosis (IPF) is a fatal disease that is unresponsive to current therapies and characterized by excessive collagen deposition and subsequent fibrosis.
Anderson, G.P., Bozinovski, S., Ernst, M.R., Jarnicki, A.G., Jones, J., Knight, D.A., Lau, H.L., Laurent, G.J., McAnulty, R.J., McKenzie, B.S., Mutsaers, S.E., O'Donoghue, R.J.J., Prêle, C.M., Richards, C.D., Rose-John, S., Stumbles, P.A., Thiem, S., Vlahos, R., Wang, B., Zhu, H.J.   +19 more
core   +2 more sources

The Novel Methylation Biomarker NPY5R Sensitizes Breast Cancer Cells to Chemotherapy

Frontiers in Cell and Developmental Biology, 2022
Breast cancer (BC) is the most common tumor in women, and the molecular mechanism underlying its pathogenesis remains unclear. In this study, we aimed to investigate gene modules related to the phenotypes of BC, and identify representative candidate ...
Jiazhou Liu, Jiazhou Liu, Xiaoyu Wang, Xiaoyu Wang, Jiazheng Sun, Jiazheng Sun, Yuru Chen, Yuru Chen, Jie Li, Jie Li, Jing Huang, Huimin Du, Lu Gan, Zhu Qiu, Hongzhong Li, Hongzhong Li, Guosheng Ren, Guosheng Ren, Yuxian Wei, Yuxian Wei   +19 more
doaj   +1 more source