Results 11 to 20 of about 179,101 (246)
The Role of Transcription Factors in Coronary Artery Disease and Myocardial Infarction
Frontiers in Bioscience-Landmark, 2022 Coronary artery disease (CAD) and its main complication, myocardial infarction (MI), is a complex disease caused by environmental and genetic factors and their interaction.
Chunyan Luo +6 more
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Frontiers in Cell and Developmental Biology, 2021 Background: Non-small cell lung cancer (NSCLC) is the most common malignancy worldwide. MiR-199a-5p has been reported to play important roles in multiple tumors, inclusive of NSCLC.
Xingping Yang +6 more
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RBM8A Promotes Glioblastoma Growth and Invasion Through the Notch/STAT3 Pathway
Frontiers in Oncology, 2021 BackgroundGlioblastoma (GBM) is a prevalent brain malignancy with an extremely poor prognosis, which is attributable to its invasive biological behavior. The RNA-binding motif protein 8A (RBM8A) has different effects on various human cancers.
Yan Lin +6 more
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Anti-melanoma SK-Mel-103 cells effect of a natural small molecule, HEP-14
陆军军医大学学报, 2022 Objective To investigate the inhibitory effect of a natural small molecule, HEP-14, on melanoma SK-Mel-103 cells and its underlying mechanism. Methods SK-Mel-103 cells were treated with HEP-14 at different concentrations (2.5~40 μmol/L).
LIU Fang +5 more
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Cell, 1999 STATs are latent transcription factors that mediate cytokine- and growth factor-directed transcription. In many human cancers and transformed cell lines, Stat3 is persistently activated, and in cell culture, active Stat3 is either required for transformation, enhances transformation, or blocks apoptosis.
Bromberg, Jacqueline F +6 more
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Frontiers in Pharmacology, 2021 Hepatocellular carcinoma (HCC) is the most frequent primary liver malignancy globally and the third leading cause of cancer-related death. Chemotherapy is one of the main methods in treating HCC, while recent studies have found that the resistance of HCC
Han Hong +8 more
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Mechanisms of immune suppression by myeloid-derived suppressor cells: the role of interleukin-10 as a key immunoregulatory cytokine [PDF]
Open Biology, 2020 Chronic immune activation and inflammation are unwanted consequences of many pathological conditions, since they could lead to tissue damage and immune exhaustion, both of which can worsen the pathological condition status.
Mahmoud Mohammad Yaseen +3 more
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STAT3 signaling in immunity [PDF]
Cytokine & Growth Factor Reviews, 2016 The transcriptional regulator STAT3 has key roles in vertebrate development and mature tissue function including control of inflammation and immunity. Mutations in human STAT3 associate with diseases such as immunodeficiency, autoimmunity and cancer.
Emily J. Hillmer +3 more
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Frontiers in Cellular Neuroscience, 2014 Emerging research has identified that neuroimmune factors are produced by cells of the central nervous system (CNS) and play critical roles as regulators of CNS function, directors of neurodevelopment and responders to pathological processes.
Donna eGruol, Khanh eVo, Jennifer eBray
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Activation-induced cell death of dendritic cells is dependent on sphingosine kinase 1
Frontiers in Pharmacology, 2016 Sphingosine 1-phosphate (S1P) is an immune modulatory lipid mediator and has been implicated in numerous pathophysiological processes. S1P is produced by sphingosine kinase 1 (Sphk1) and Sphk2.
Anja eSchwiebs +5 more
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