Results 11 to 20 of about 250,824 (344)
Mitochondrial STAT3 exacerbates LPS-induced sepsis by driving CPT1a-mediated fatty acid oxidation
Theranostics, 2022 Rationale: We found that a subset of signal transducer and activator of transcription 3 (STAT3) translocated into mitochondria in phagocytes, including macrophages isolated from individuals with sepsis.
Rongqing Li +16 more
semanticscholar +1 more source
STAT3 pathway in cancers: Past, present, and future
MedComm, 2022 Signal transducer and activator of transcription 3 (STAT3), a member of the STAT family, discovered in the cytoplasm of almost all types of mammalian cells, plays a significant role in biological functions.
Hanyi Wang +11 more
semanticscholar +1 more source
The Multifaced Role of STAT3 in Cancer and Its Implication for Anticancer Therapy
International Journal of Molecular Sciences, 2021 Signal transducer and activator of transcription (STAT) 3 is one of the most complex regulators of transcription. Constitutive activation of STAT3 has been reported in many types of tumors and depends on mechanisms such as hyperactivation of receptors ...
M. Tolomeo, A. Cascio
semanticscholar +1 more source
Frontiers in Pharmacology, 2021 Hepatocellular carcinoma (HCC) is the most frequent primary liver malignancy globally and the third leading cause of cancer-related death. Chemotherapy is one of the main methods in treating HCC, while recent studies have found that the resistance of HCC
Han Hong +8 more
doaj +1 more source
IL-6/STAT3 Is a Promising Therapeutic Target for Hepatocellular Carcinoma
Frontiers in Oncology, 2021 Hepatocellular carcinoma (HCC) is a common malignant tumor of which the occurrence and development, the tumorigenicity of HCC is involving in multistep and multifactor interactions.
Junnv Xu +4 more
semanticscholar +1 more source
STAT3: A multifaceted oncogene [PDF]
Proceedings of the National Academy of Sciences, 2006 Signal transducers and activators of transcription (STAT) proteins are a family of transcription factors first characterized for their role in cytokine signaling. These versatile proteins contain a site for specific tyrosine phosphorylation, a modification that results in a conformational rearrangement and dimerization through phosphotyrosine–SH2 ...
D. E. LEVY, INGHIRAMI, Giorgio
openaire +3 more sources
OncoImmunology, 2020 Stat3 is constitutively activated in several tumor types and plays an essential role in maintaining their malignant phenotype and immunosupression. To take advantage of the promising antitumor activity of Stat3 targeting, it is vital to understand the ...
Mara De Martino +13 more
doaj +1 more source
陆军军医大学学报, 2023 Objective To explore the exposure of decarbromo diphenyl ether (BDE-209), a new persistent organic pollutant (POP) with the highest level in human body, on the migration of triple-negative breast cancer (TNBC) cell line MDE-MB-231, and explore the ...
XIE Shangfu +3 more
doaj +1 more source
Targeting STAT3 in Cancer Immunotherapy
Molecular Cancer, 2020 As a point of convergence for numerous oncogenic signaling pathways, signal transducer and activator of transcription 3 (STAT3) is central in regulating the anti-tumor immune response.
Sailan Zou +5 more
semanticscholar +1 more source
Membrane-associated STAT3 and PY-STAT3 in the Cytoplasm [PDF]
Journal of Biological Chemistry, 2006 Signal transduction from the plasma membrane to the nucleus by STAT proteins is widely represented as exclusively a soluble cytosolic process. Using cell-fractionation methods, we observed that approximately 5% of cytoplasmic STAT3 was constitutively associated with the purified early endosome (EE) fraction in human Hep3B liver cells.
Mehul, Shah +5 more
openaire +2 more sources