Results 21 to 30 of about 179,101 (246)
Frontiers in Medicine, 2021 The aim of the present study was to investigate the effect of erythropoietin (EPO) on contrast-induced nephrology (CIN) in vivo and in vitro. Male C57BL/6J mice were divided into four groups: control, CIN (iohexol 6.0 g/kg), EPO (3,000 IU/kg), and CIN ...
Jia Yang +6 more
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T cell activation or tolerization: the Yin and Yang of bacterial superantigens
Frontiers in Microbiology, 2015 Bacterial superantigens are exotoxins from pathogens which interact with innate and adaptive immune cells. The paradox that superantigens cause activation and inactivation/anergy of T-cells was soon recognized.
Aline eSähr +3 more
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Frontiers in Molecular Biosciences, 2021 Neuroinflammation is a key pathological factor in numerous neurological disorders. Cumulating evidence has indicated critical roles of NAD+/NADH metabolism in multiple major diseases, while the role of malate-aspartate shuttle (MAS) - a major NADH ...
Cuiyan Zhou +5 more
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ECHS1 interacts with STAT3 and negatively regulates STAT3 signaling
FEBS Letters, 2013 STAT3 physically interacts with ECHS1 by anti bait co immunoprecipitation (View interaction)
Chang, Yan +10 more
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Frontiers in Neuroscience, 2013 In the mouse hypothalamus, ciliary neurotrophic factor (CNTF) is mainly expressed by ependymal cells and tanycytes of the ependymal layer covering the third ventricle.
Ilenia eSeveri +7 more
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Disease Models & Mechanisms, 2020 Colorectal cancer (CRC) is often accompanied by formation of liver metastases (LM) and skeletal muscle wasting, i.e. cachexia. Despite affecting the majority of CRC patients, cachexia remains underserved, understudied and uncured.
Joshua R. Huot +3 more
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Where Sin3a Meets STAT3: Balancing STAT3-Mediated Transcriptional Activation and Repression [PDF]
Cancer Research, 2019 Abstract STAT3 can mediate epigenetic silencing of tumor suppressor genes (TSG). However, little is known about the molecular mechanisms involved, except that this action is mediated by DNA methylation and requires STAT3 acetylation. In this issue of Cancer Research, Gambi and colleagues confirm that oncogene-driven constitutive STAT3 ...
Emanuele Monteleone, Valeria Poli
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Flurbiprofen ameliorates glucose deprivation-induced leptin resistance
Frontiers in Pharmacology, 2016 Leptin resistance is one of the mechanisms involved in the pathophysiology of obesity. The present study showed that glucose deprivation inhibited leptin-induced phosphorylation of signal transducer and activator of transcription 3 (STAT3) and signal ...
Toru Hosoi +3 more
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Cancer Biology & Therapy, 2023 Daucosterol is a phytosterol glycoside with hepatoprotective properties. The objective of the present study was to confirm the role of daucosterol in liver failure. Exosomes were isolated from primary mouse umbilical cord mesenchymal stem cells (UCMSCs).
Changqing Deng +8 more
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Psoriasis: A STAT3-Centric View [PDF]
International Journal of Molecular Sciences, 2018 Signal Transducer and Activator of Transcription (STAT)3 has recently emerged as a key player in the development and pathogenesis of psoriasis and psoriatic-like inflammatory conditions. Indeed, STAT3 hyperactivation has been reported in virtually every cell type involved in disease initiation and maintenance, and this factor mediates the signal of ...
Calautti, Enzo +2 more
openaire +4 more sources