Results 21 to 30 of about 250,824 (344)
Cells, 2020 The JAK/STAT3 signaling pathway plays an essential role in various types of cancers. Activation of this pathway leads to increased tumorigenic and metastatic ability, the transition of cancer stem cells (CSCs), and chemoresistance in cancer via enhancing
W. Jin
semanticscholar +1 more source
Disease Models & Mechanisms, 2020 Colorectal cancer (CRC) is often accompanied by formation of liver metastases (LM) and skeletal muscle wasting, i.e. cachexia. Despite affecting the majority of CRC patients, cachexia remains underserved, understudied and uncured.
Joshua R. Huot +3 more
doaj +1 more source
Disease Models & Mechanisms, 2022 RET is a receptor tyrosine kinase with oncogenic potential in the mammary epithelium. Several receptors with oncogenic activity in the breast are known to participate in specific developmental stages.
Sabrina A. Vallone +8 more
doaj +1 more source
Arbutin Ameliorates Murine Colitis by Inhibiting JAK2 Signaling Pathway
Frontiers in Pharmacology, 2021 Background and objective: Abnormal activation of Janus kinase 2 (JAK2) promotes the pathogenesis and progress of inflammatory bowel disease (IBD) by stimulating the cytokine traffic.
Liang Wang +10 more
doaj +1 more source
STAT3 Mutation Is Associated with STAT3 Activation in CD30+ ALK− ALCL [PDF]
Cancers, 2020 Peripheral T-cell lymphomas (PTCL) are a heterogeneous, and often aggressive group of non-Hodgkin lymphomas. Recent advances in the molecular and genetic characterization of PTCLs have helped to delineate differences and similarities between the various subtypes, and the JAK/STAT pathway has been found to play an important oncogenic role.
Emma I. Andersson +10 more
openaire +3 more sources
Epigenetics, 2023 N6-Methyladenosine (m6A) plays a key role in the occurrence and development of various cancers. Fat mass and obesity‐associated protein (FTO) was is involved in multiple cancers owing to its demethylase activity, and the molecular mechanism underlying ...
Zhuang Sun +5 more
doaj +1 more source
Activation-induced cell death of dendritic cells is dependent on sphingosine kinase 1
Frontiers in Pharmacology, 2016 Sphingosine 1-phosphate (S1P) is an immune modulatory lipid mediator and has been implicated in numerous pathophysiological processes. S1P is produced by sphingosine kinase 1 (Sphk1) and Sphk2.
Anja eSchwiebs +5 more
doaj +1 more source
Blood, 2021 AML is characterized by the presence of leukemia stem cells (LSCs), and failure to fully eradicate this population contributes to disease persistence/relapse.
M. Amaya +14 more
semanticscholar +1 more source
T cell activation or tolerization: the Yin and Yang of bacterial superantigens
Frontiers in Microbiology, 2015 Bacterial superantigens are exotoxins from pathogens which interact with innate and adaptive immune cells. The paradox that superantigens cause activation and inactivation/anergy of T-cells was soon recognized.
Aline eSähr +3 more
doaj +1 more source
Frontiers in Neuroscience, 2013 In the mouse hypothalamus, ciliary neurotrophic factor (CNTF) is mainly expressed by ependymal cells and tanycytes of the ependymal layer covering the third ventricle.
Ilenia eSeveri +7 more
doaj +1 more source