Results 31 to 40 of about 250,824 (344)
Role of STAT3 signaling pathway in breast cancer
Cell Communication and Signaling, 2020 Breast cancer has grown to be the second leading cause of cancer-related deaths in women. Only a few treatment options are available for breast cancer due to the widespread occurrence of chemoresistance, which emphasizes the need to discover and develop ...
Jia-hui Ma, L. Qin, Xia Li
semanticscholar +1 more source
Flurbiprofen ameliorates glucose deprivation-induced leptin resistance
Frontiers in Pharmacology, 2016 Leptin resistance is one of the mechanisms involved in the pathophysiology of obesity. The present study showed that glucose deprivation inhibited leptin-induced phosphorylation of signal transducer and activator of transcription 3 (STAT3) and signal ...
Toru Hosoi +3 more
doaj +1 more source
OncoImmunology, 2018 Exosomes can mediate a dynamic method of communication between malignancies, including those sequestered in the central nervous system and the immune system.
Konrad Gabrusiewicz +34 more
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The effect of high-intensity interval training on IL-22 and STAT3 gene expression of liver tissue in steatosis animal model [PDF]
Journal of Exercise & Organ Cross Talk, 2023 Inflammation is a major component of almost all acute and chronic liver disorders, including non-alcoholic fatty liver disease. This study aimed to investigate the effect of high-intensity interval training on IL-22 and STAT3 gene expression of liver ...
Vahideh Ebrahimi Gharab +3 more
doaj +1 more source
Cell, 1999 STATs are latent transcription factors that mediate cytokine- and growth factor-directed transcription. In many human cancers and transformed cell lines, Stat3 is persistently activated, and in cell culture, active Stat3 is either required for transformation, enhances transformation, or blocks apoptosis.
Bromberg, Jacqueline F +6 more
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Targeting STAT3 Signaling Pathway in Colorectal Cancer
Biomedicines, 2021 Signal transducer and activator of transcription 3 (STAT3) is a critical transcription factor that has been firmly associated with colorectal cancer (CRC) initiation and development. STAT3 mediates key inflammatory mechanisms in colitis-associated cancer,
A. Gargalionis +2 more
semanticscholar +1 more source
Gut and Liver, 2021 Background/Aims: Interleukin-22 (IL-22) is an important cytokine maintaining homeostasis at barrier surfaces. In this study, the role of IL-22 in acute pancreatitis-associated intestinal injury was further explored.
Jinxia Bai, Jinyun Bai, Meng Yang
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STAT3 signaling in immunity [PDF]
Cytokine & Growth Factor Reviews, 2016 The transcriptional regulator STAT3 has key roles in vertebrate development and mature tissue function including control of inflammation and immunity. Mutations in human STAT3 associate with diseases such as immunodeficiency, autoimmunity and cancer.
Emily J. Hillmer +3 more
openaire +2 more sources
STAT3 is critical for skeletal development and bone homeostasis by regulating osteogenesis
Nature Communications, 2021 Skeletal deformities are typical AD-HIES manifestations, which are mainly caused by heterozygous and loss-of-function mutations in Signal transducer and activator of transcription 3 (STAT3).
Siru Zhou +8 more
semanticscholar +1 more source
Mechanisms of immune suppression by myeloid-derived suppressor cells: the role of interleukin-10 as a key immunoregulatory cytokine [PDF]
Open Biology, 2020 Chronic immune activation and inflammation are unwanted consequences of many pathological conditions, since they could lead to tissue damage and immune exhaustion, both of which can worsen the pathological condition status.
Mahmoud Mohammad Yaseen +3 more
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