Results 31 to 40 of about 179,101 (246)

Glioblastoma stem cell-derived exosomes induce M2 macrophages and PD-L1 expression on human monocytes

OncoImmunology, 2018
Exosomes can mediate a dynamic method of communication between malignancies, including those sequestered in the central nervous system and the immune system.
Konrad Gabrusiewicz, Xu Li, Jun Wei, Yuuri Hashimoto, Anantha L. Marisetty, Martina Ott, Fei Wang, David Hawke, John Yu, Luke M. Healy, Anwar Hossain, Johnny C. Akers, Sourindra N. Maiti, Shinji Yamashita, Yuzaburo Shimizu, Kenneth Dunner, M. Anna Zal, Jared K. Burks, Joy Gumin, Felix Nwajei, Aras Rezavanian, Shouhao Zhou, Ganesh Rao, Raymond Sawaya, Gregory N. Fuller, Jason T. Huse, Jack P. Antel, Shulin Li, Laurence Cooper, Erik P. Sulman, Clark Chen, Changiz Geula, Raghu Kalluri, Tomasz Zal, Amy B. Heimberger   +34 more
doaj   +1 more source

STAT3 single nucleotide polymorphism rs4796793 SNP does not correlate with response to adjuvant IFNα therapy in stage III melanoma patients

Frontiers in Medicine, 2014
Interferon alpha (IFNα) is approved for adjuvant treatment of stage III melanoma in Europe and the US. Its clinical efficacy, however, is restricted to a subpopulation of patients while side effects occur in most of treated patients.
David eSchrama, Selma eUgurel, Antje eSucker, Cathrin eRitter, Cathrin eRitter, Marc eZapatka, Dirk eSchadendorf, Juergen Christian Becker, Juergen Christian Becker, Juergen Christian Becker   +9 more
doaj   +1 more source

Blockade of Stat3 oncogene addiction induces cellular senescence and reveals a cell-nonautonomous activity suitable for cancer immunotherapy

OncoImmunology, 2020
Stat3 is constitutively activated in several tumor types and plays an essential role in maintaining their malignant phenotype and immunosupression. To take advantage of the promising antitumor activity of Stat3 targeting, it is vital to understand the ...
Mara De Martino, Mercedes Tkach, Sofía Bruni, Darío Rocha, María F. Mercogliano, Mauro E. Cenciarini, María F. Chervo, Cecilia J. Proietti, Florent Dingli, Damarys Loew, Elmer A. Fernández, Patricia V. Elizalde, Eliane Piaggio, Roxana Schillaci   +13 more
doaj   +1 more source

Arbutin Ameliorates Murine Colitis by Inhibiting JAK2 Signaling Pathway

Frontiers in Pharmacology, 2021
Background and objective: Abnormal activation of Janus kinase 2 (JAK2) promotes the pathogenesis and progress of inflammatory bowel disease (IBD) by stimulating the cytokine traffic.
Liang Wang, Liang Wang, Yuntao Feng, Jianwen Wang, Tenglong Luo, Xinyue Wang, Mengze Wu, Runxia Wang, Dapeng Chen, Jiyan Li, Jingyu Wang   +10 more
doaj   +1 more source

Stat3 Regulates Developmental Hematopoiesis and Impacts Myeloid Cell Function via Canonical and Non-Canonical Modalities

Journal of Innate Immunity
Introduction: Signal transducer and activator of transcription (STAT) 3 is extensively involved in the development, homeostasis, and function of immune cells, with STAT3 disruption associated with human immune-related disorders.
Mohamed Luban Sobah, Clifford Liongue, Alister C. Ward   +2 more
doaj   +1 more source

Differential silencing of STAT3 isoforms leads to changes in STAT3 activation

Oncotarget, 2023
Signal transducer and activator of transcription 3 (STAT3) is a transcription factor involved in multiple fundamental biological processes and a key player in cancer development and progression. STAT3 is activated upon tyrosine phosphorylation and is constitutively active in various malignancies; therefore, the expression of pSTAT3 has been recognized ...
Shamir, Inbal, Tsarfaty, Ilan, Paret, Gidi, Nevo-Caspi, Yael   +3 more
openaire   +2 more sources

ZFAS1/STAT3 axis modulates imatinib resistance of chronic myeloid leukemia cells through glucose metabolism reprogramming

Frontiers in Oncology
BackgroundChronic myeloid leukemia (CML) is a myeloproliferative neoplasm characterized by the presence of the Philadelphia chromosome (chromosome 22). This cytogenetic abnormality gives rise to the BCR::ABL1 fusion gene, which encodes the constitutively
Lan Yang, Yanqiu Han
doaj   +1 more source

Meme Kanserinde Tamoksifen Direncinde IL-6/STAT3 Yolağı Temelli EMT Mekanizmasının Rolünün Araştırılması

Sakarya Tıp Dergisi, 2022
Amaç: Tamoksifen östrojen reseptörlerine seçici bir şekilde bağlanarak anti-östrojenik etki gösteren ve östrojen reseptörü pozitif (ER+) meme kanseri hastalarının endokrin tedavisinde kullanılan bir ajandır.
Gamze Güney Eskiler, Erhan Bezdegümeli, Ahmet Yasir Men, Merve Nur İnce, Asuman Deveci Özkan   +4 more
doaj   +1 more source

Network pharmacology to explore the novel anti-inflammatory mechanism of naringenin in intestinal ischemia/reperfusion injury

Frontiers in Immunology
IntroductionNaringenin (Nar), a common flavanone abundant in citrus fruits and tomatoes, is common in diets. Although Nar can alleviate intestinal ischemia/reperfusion injury (IRI), the exact anti-inflammatory mechanisms are unclear and require further ...
Min Hou, Yanshun Wang, Suheng Chen, Zhiguo Tan, Jie Liu, Xiaoxi Li, Xiaoxia Han, Zaiqi Yang, Yufang Leng, Yufang Leng   +9 more
doaj   +1 more source

STAT3-induced S1PR1 expression is crucial for persistent STAT3 activation in tumors [PDF]

Nature Medicine, 2010
Interleukin-6 (IL-6)-Janus kinase (JAK) signaling is viewed as crucial for persistent signal transducer and activator of transcription-3 (STAT3) activation in cancer. However, IL-6-induced STAT3 activation is normally transient. Here we identify a key mechanism for persistent STAT3 activation in tumor cells and the tumor microenvironment.
Lee, Heehyoung, Deng, Jiehui, Kujawski, Maciej, Yang, Chunmei, Liu, Yong, Herrmann, Andreas, Kortylewski, Marcin, Horne, David, Somlo, George, Forman, Stephen, Jove, Richard, Yu, Hua   +11 more
openaire   +2 more sources