Results 41 to 50 of about 250,824 (344)
ECHS1 interacts with STAT3 and negatively regulates STAT3 signaling
FEBS Letters, 2013 STAT3 physically interacts with ECHS1 by anti bait co immunoprecipitation (View interaction)
Chang, Yan +10 more
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Frontiers in Pharmacology, 2022 The rapid growth of vascular smooth muscle cells (VSMCs) represents crucial pathological changes during the development of hypertensive vascular remodeling. Although quercetin exhibits significantly therapeutic effects on antihypertension, the systematic
Di Wang +33 more
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Where Sin3a Meets STAT3: Balancing STAT3-Mediated Transcriptional Activation and Repression [PDF]
Cancer Research, 2019 Abstract STAT3 can mediate epigenetic silencing of tumor suppressor genes (TSG). However, little is known about the molecular mechanisms involved, except that this action is mediated by DNA methylation and requires STAT3 acetylation. In this issue of Cancer Research, Gambi and colleagues confirm that oncogene-driven constitutive STAT3 ...
Emanuele Monteleone, Valeria Poli
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Detection of Leptin Activity in Living Cells Expressing Chicken Leptin Receptor and STAT3
The Journal of Poultry Science, 2012 The chicken leptin receptor (chLEPR) activates Janus kinase (JAK) - signal transducers and activator of transcription (STAT) signaling pathway after leptin stimulation.
Hiromi Adachi +3 more
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Frontiers in Medicine, 2021 The aim of the present study was to investigate the effect of erythropoietin (EPO) on contrast-induced nephrology (CIN) in vivo and in vitro. Male C57BL/6J mice were divided into four groups: control, CIN (iohexol 6.0 g/kg), EPO (3,000 IU/kg), and CIN ...
Jia Yang +6 more
doaj +1 more source
Psoriasis: A STAT3-Centric View [PDF]
International Journal of Molecular Sciences, 2018 Signal Transducer and Activator of Transcription (STAT)3 has recently emerged as a key player in the development and pathogenesis of psoriasis and psoriatic-like inflammatory conditions. Indeed, STAT3 hyperactivation has been reported in virtually every cell type involved in disease initiation and maintenance, and this factor mediates the signal of ...
Calautti, Enzo +2 more
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Frontiers in Molecular Biosciences, 2021 Neuroinflammation is a key pathological factor in numerous neurological disorders. Cumulating evidence has indicated critical roles of NAD+/NADH metabolism in multiple major diseases, while the role of malate-aspartate shuttle (MAS) - a major NADH ...
Cuiyan Zhou +5 more
doaj +1 more source
Redox Regulation of STAT1 and STAT3 Signaling
International Journal of Molecular Sciences, 2020 STAT1 and STAT3 are nuclear transcription factors that regulate genes involved in cell cycle, cell survival and immune response. The cross-talk between these signaling pathways determines how cells integrate the environmental signals received ultimately ...
Elena Butturini +2 more
semanticscholar +1 more source
Frontiers in Pharmacology, 2022 Gastric cancer is a common malignant tumor that threatens human health, and its occurrence and development mechanism is a complex process involving multiple genes and multiple signals.
Haobin Li +14 more
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Differential silencing of STAT3 isoforms leads to changes in STAT3 activation
Oncotarget, 2023 Signal transducer and activator of transcription 3 (STAT3) is a transcription factor involved in multiple fundamental biological processes and a key player in cancer development and progression. STAT3 is activated upon tyrosine phosphorylation and is constitutively active in various malignancies; therefore, the expression of pSTAT3 has been recognized ...
Shamir, Inbal +3 more
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