Results 51 to 60 of about 250,824 (344)
Unraveling the complexity of STAT3 in cancer: molecular understanding and drug discovery
Journal of experimental & clinical cancer research : CRSignal transducer and activator of transcription 3 (STAT3) is a transcriptional factor involved in almost all cancer hallmark features including tumor proliferation, metastasis, angiogenesis, immunosuppression, tumor inflammation, metabolism ...
Yamei Hu, Zigang Dong, Kangdong Liu
semanticscholar +1 more source
The nuclear events guiding successful nerve regeneration
Frontiers in Molecular Neuroscience, 2011 Peripheral nervous system (PNS) neurons survive and regenerate after nerve injury, whereas central nervous system (CNS) neurons lack the capacity to do so.
Sumiko eKiryu-Seo, Hiroshi eKiyama
doaj +1 more source
Sakarya Tıp Dergisi, 2022 Amaç: Tamoksifen östrojen reseptörlerine seçici bir şekilde bağlanarak anti-östrojenik etki gösteren ve östrojen reseptörü pozitif (ER+) meme kanseri hastalarının endokrin tedavisinde kullanılan bir ajandır.
Gamze Güney Eskiler +4 more
doaj +1 more source
STAT3 as a potential therapeutic target in triple negative breast cancer: a systematic review
Journal of experimental & clinical cancer research : CR, 2019 Triple negative breast cancer (TNBC), which is typically lack of expression of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2), represents the most aggressive and mortal subtype of breast cancer ...
Jiangjiang Qin +3 more
semanticscholar +1 more source
STAT3 and its targeting inhibitors in osteosarcoma
Cell Proliferation, 2020 Signal transducer and activator of transcription 3 (STAT3) is one of seven STAT family members involved with the regulation of cellular growth, differentiation and survival.
Yun Liu +7 more
semanticscholar +1 more source
STAT3-induced S1PR1 expression is crucial for persistent STAT3 activation in tumors [PDF]
Nature Medicine, 2010 Interleukin-6 (IL-6)-Janus kinase (JAK) signaling is viewed as crucial for persistent signal transducer and activator of transcription-3 (STAT3) activation in cancer. However, IL-6-induced STAT3 activation is normally transient. Here we identify a key mechanism for persistent STAT3 activation in tumor cells and the tumor microenvironment.
Lee, Heehyoung +11 more
openaire +2 more sources
Inhibition of Stat3‐mediated astrogliosis ameliorates pathology in an Alzheimer's disease model
EMBO Molecular Medicine, 2019 Reactive astrogliosis is a hallmark of Alzheimer's disease (AD), but its role for disease initiation and progression has remained incompletely understood.
N. Reichenbach +7 more
semanticscholar +1 more source
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
ACT001 reduces the expression of PD-L1 by inhibiting the phosphorylation of STAT3 in glioblastoma
Theranostics, 2020 ACT001, which is derived from an ancient anti-inflammatory drug, has been shown to cross the blood-brain barrier in preclinical studies and has demonstrated anti-glioblastoma (GBM) activity in clinical trials.
Luqing Tong +18 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser +14 more
wiley +1 more source