Results 111 to 120 of about 4,534,601 (246)

T Cell Microenvironmental Impacts and Therapeutic Opportunities: Application to Human Testicular Germ Cell Tumors

Andrology, EarlyView.
ABSTRACT Testicular germ cell tumors (TGCT) are the leading malignancy in adolescent and young adult males, yet the immunological and cellular mechanisms governing their tumor microenvironment (TME) remain poorly understood. Here, we present a comprehensive review of TGCT pathobiology with a focus on the immune landscape, particularly the role of tumor‐
R Islam, M Figura, J Heyer, S Lieber, M Huber, KL Loveland, HC Schuppe, Daniela Fietz   +7 more
wiley   +1 more source

Tomato heat stress transcription factor HsfB1 represents a novel type of general transcription coactivator with a histone-like motif interacting with HAC1/CBP [PDF]

, 2005
In contrast to the class A heat stress transcription factors (Hsfs) of plants, a considerable number of Hsfs assigned to classes B and C have no evident function as transcription activators on their own.
Bharti, Kapil
core  

MotifAdjuster: a tool for computational reassessment of transcription factor binding site annotations [PDF]

, 2009
Keilwagen J, Baumbach J, Kohl TA, Grosse I. MotifAdjuster: a tool for computational reassessment of transcription factor binding site annotations. Genome Biology. 2009;10(5):R46.Valuable binding-site annotation data are stored in databases.
Thomas A Kohl, Ivo Grosse, Kohl, Thomas A., Jan Baumbach, Grosse, Ivo, Baumbach, Jan, Jens Keilwagen, Keilwagen, Jens   +7 more
core   +1 more source

Effect of the Chinese Herb Extract Osthol on IL-4-induced Eotaxin Expression in BEAS-2B Cells

Pediatrics and Neonatology, 2008
Asthma is an allergic inflammatory disease of the airways. The interaction between bronchial epithelial cells and eosinophils is an important feature of an asthma attack. Eotaxin, an eosinophil-specific C-C chemokine, is a potent chemoattractant involved
Pu-Rong Chiu, Wei-Te Lee, Yu-Te Chu, Min-Sheng Lee, Yuh-Jyh Jong, Chih-Hsing Hung   +5 more
doaj   +1 more source

Adenosine—A Regulator of Human Testicular Peritubular Cells

Andrology, EarlyView.
ABSTRACT Background Extracellular purines, in particular ATP and adenosine, are regulators of physiological and pathophysiological processes throughout the human body. Roles in the human testis are emerging and include actions on peritubular cells, which form the wall of seminiferous tubules.
Lina Scholz, Annika Liebich, Youli Stepanov, Jan B. Stöckl, Mirko Peitzsch, Michaela Schneider, Julia Schneider, Nicole Kreitmair, Matthias Trottmann, Frank‐Michael Köhn, Jovica Ninkovic, Thomas Fröhlich, Artur Mayerhofer   +12 more
wiley   +1 more source

THE IMPORTANCE OF TRANSCRIPTION FACTORS STAT6, STAT4, GATA-3 AND T-bet COOPERATION WHEN BRONCHIAL ASTHMA HAS BEEN DIAGNOSED

Medical academic journal, 2013
Lymphocyte signal systems cross-talk interactions present complex net consisting of receptors, enzymes and transcription factors. Using Western blotting for analyzing STAT6, STAT4, GATA-3 and T-bet content in mononuclears, derived from 96 asthma patient and 20 healthy persons, we revealed increase of STAT6 and GATA-3 levels and decrease of STAT4 and T ...
V I Trophimov, V N Mineyev, L N Sorokina, M A Nema, V V Lim, A V Yeremeyeva   +5 more
openaire   +1 more source

Extracellular vesicles in pharmacology: Innovations in drug delivery and therapeutic applications in cancer

British Journal of Pharmacology, EarlyView.
Extracellular vesicles (EVs) are a diverse population of membrane nanoparticles secreted by nearly all cell types, playing a key role in intercellular communication by transferring bioactive macromolecular cargo. In cancer, EVs shape both the local tumour microenvironment and distant premetastatic niches.
Evangelia Pantazaka, Georgios Sivvas, Evangelia Papadimitriou, Constantinos M. Mikelis   +3 more
wiley   +1 more source

Prognostic significance of STAT6 and the autophagy related marker beclin-1 expression in different molecular breast carcinoma subtypes in relation to clinicopathological characteristics

Egyptian Journal of Cancer and Biomedical Research
Background: Multiple biomarkers and gene expression profiles have revolutionized diagnosis and treatment strategies of breast carcinoma patients by specifying distinct molecular subtypes; that guide individualized therapy.
Asmaa Eid, radwa awad, Alshimaa Eltawab, Alaa Amer   +3 more
doaj   +1 more source

C/EBP Homologous Protein (CHOP) Activates Macrophages and Promotes Liver Fibrosis in Schistosoma japonicum-Infected Mice

Journal of Immunology Research, 2019
CCAAT/enhancer-binding homologous protein (CHOP), a transcriptional regulator induced by endoplasmic reticulum stress (ER stress) is a pivotal factor in the ER stress-mediated apoptosis pathway.
Mengyun Duan, Yuan Yang, Shuang Peng, Xiaoqin Liu, Jixin Zhong, Yurong Guo, Min Lu, Hao Nie, Boxu Ren, Xiangzhi Zhang, Lian Liu   +10 more
doaj   +1 more source

tRNA‐Derived Small RNAs in Digestive Cancers: From Translational Regulation to Immune and Extracellular Communication

Cancer Science, EarlyView.
tRNA‐derived small RNAs (tsRNAs) function in digestive cancers across three scales: intracellular translational and metabolic control, extracellular vesicle–mediated immune remodeling, and systemic and host–microbe communication. This review organizes these mechanisms by evidence strength, from well‐established intracellular roles to emerging ...
Wang Xitan, Li Han
wiley   +1 more source