Results 141 to 150 of about 4,534,601 (246)

Neurobiological mechanisms of 40‐Hz stimulation in Alzheimer's disease: evidence, heterogeneity, and constraints

Alzheimer's &Dementia, Volume 22, Issue 9, September 2026.
Abstract Early disruption of gamma oscillations is increasingly recognized as a contributor to neurodegeneration and cognitive decline in Alzheimer's disease (AD), positioning 40‐Hz stimulation as a promising neuromodulatory strategy. However, its neurophysiological and cognitive effects remain highly variable across studies, underscoring the need for ...
Lin Qi, Weiye Wang, Reema Abdullah, Yilei Zhao, Zhibin Wang, Yi Tang, Benyan Luo, Guoping Peng   +7 more
wiley   +1 more source

Yiqihuoxue formula improves atherosclerosis by regulating macrophage polarization associated with enhanced STAT6/PPARγ pathway

Frontiers in Cardiovascular Medicine
BackgroundAtherosclerosis (AS) is a major contributor to deaths from cardiovascular diseases. Yiqihuoxue Formula (YQHXF) reflects the traditional Chinese medicine principle of “Qi-invigorating and blood-activating.” This study investigates the anti ...
Quan Xie, Binding Wang, Jinli Zhuang, Yi Guan, Xiaohong Yang, Jianfeng Li, Shengyu Cun, Yanting Chen, Ya Qin, Yanqing Li   +9 more
doaj   +1 more source

Acupuncture for Poststroke Dysphagia: An NTS‐Centered Hypothesis‐Generating Framework Linking the Brainstem Swallowing Network, Neuroimmune Regulation, and Vagal Anti‐Inflammatory Signaling

Brain and Behavior, Volume 16, Issue 9, September 2026.
ABSTRACT Background Poststroke dysphagia (PSD) may reflect not only focal motor pathway injury but also instability of the brainstem swallowing network under neuroimmune, glial, and vascular microenvironmental stress. Methods This mechanism‐oriented narrative review synthesized evidence on swallowing central pattern generator (CPG) organization ...
Wei Li, Lebin Liu, Yingying Tu, Chongjiu Gong, Xiao Ran, Jiuguo Pei   +5 more
wiley   +1 more source

IL-4-STAT6-induced high Siglec-G/10 expression aggravates the severe immune suppressive tumor microenvironment and impedes the efficacy of immunotherapy in head and neck squamous cell carcinoma

Journal for ImmunoTherapy of Cancer
Background Immune checkpoint blockade therapy has shown limited efficacy in head and neck squamous cell carcinoma (HNSCC). Sialic acid binding immunoglobulin-like lectin (Siglec)-15 has been identified as a novel immune evasion biomarker, while the role ...
Ming Yan, Wenyi Yang, Zhaoyang Guo, Houyu Ju, Yusheng Lu, Yifan Fei, Yuanchen Yin, Guoxin Ren, Chaofeng Han, Jingzhou Hu   +9 more
doaj   +1 more source

Exosomal PSMD1 Derived From Dental Pulp Mesenchymal Stem Cells Promotes Microglial M2 Polarization to Alleviate Spinal Cord Injury

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
DPMSCs‐derived exosomal PSMD1 stimulates M2 polarization through the JAK2/STAT3 pathway. DPMSCs‐derived exosomal PSMD1 indirectly acts on NE‐4C cells. DPMSCs‐derived exosomal PSMD1 ameliorates SCI in a mouse model. ABSTRACT Background Exosomes derived from mesenchymal stem cells (MSCs) and their cargo contribute to the protective properties of MSCs in ...
Xiaohui Xing, Yuan Hao, Guanghui Zhang, Xiaoyang Xing, Hongfei Jia, Chenlong Liu, Xin Wang, Tao Li, Xueyuan Li, Yilei Xiao   +9 more
wiley   +1 more source

LANA enhances the inhibitory function of STAT6 on transcription of RTA through STAT6-binding sites within RTA promoter.

, 2017
(A) Schematic of putative STAT6-binding sites within RTA and LANA promoters. The RTA (or LANA) promoter-driven luciferase reporters RTAp-Luc (or LANAp-Luc) are shown at the bottom panel.
Yuhong Li (448146), Chong Wang (120449), Shujun Gao (132959), Yin Tong (789660), Liming Zhang (213971), Jianqing Xu (135427), Erle S. Robertson (177370), Zhenghong Yuan (12153), Fang Wei (31236), Yanling Feng (294987), Bin Wang (30851), Caixia Zhu (344874), Qiliang Cai (180057)   +12 more
core   +1 more source

Microglia and neuroinflammation: An in‐depth analysis from functional diversity to disease mechanisms

Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.
1. Microglial functions arise from dynamic, context‐dependent programs rather than fixed M1/M2 phenotypes. 2. Inflammatory, interferon‐responsive, phagocytic/lipid‐metabolic and repair‐associated programs coexist across disease stages and brain regions. 3.
Jie Chen, Wangzheqi Zhang, Lizhou Song, Yan Liao, Haoling Zhang, Yiyang Xia, Derong Cui   +6 more
wiley   +1 more source

STAT6-deficient mice do not show any deficiency in Chlamydia clearance.

(A) IFUs isolated from vaginal swabs at various time points after infection. For wild-type mice n = 10, STAT6-deficient mice n = 10, and MHC class II-deficient mice n = 5.
Kevin D. Fong (17721439), Claire Morris (2019940), Jordan A. Rixon (12127234), Claire E. Depew (12127237), Stephen J. McSorley (9079957), Alana T. Nguyen (17721442)   +5 more
core   +1 more source

Herbal Extracts and Plant‐Derived Bioactives in Atopic Dermatitis: Evidence, Mechanisms, Pediatric Safety, and Translational Priorities

Food Science &Nutrition, Volume 14, Issue 9, September 2026.
Food‐derived bioactives, herbal extracts, and standardized botanical products are being investigated as adjunctive strategies for atopic dermatitis. Their biological activity is shaped not only by plant source and nominal dose, but also by fermentation, drying, heating, extraction, food‐matrix binding, gastrointestinal transformation, and formulation ...
Muhuang Zeng, Qianlan Yuan, Shuojia Huang, Xiaofei Lu   +3 more
wiley   +1 more source

Inflammatory Bowel Disease: Mechanisms and Therapeutic Advances

MedComm, Volume 7, Issue 9, September 2026.
Inflammatory bowel disease (IBD), encompassing ulcerative colitis and Crohn's disease, is a rising, multifactorial chronic disorder driven by dysregulated mucosal immunity in genetically susceptible individuals and influenced by environmental and microbial factors.
Andrea Papait, Anna Cargnoni, Franco Scaldaferri, Loris Lopetuso, Antonietta Rosa Silini, Ornella Parolini   +5 more
wiley   +1 more source