Results 61 to 70 of about 4,534,601 (246)

Pneumocystis Exacerbates Inflammation and Mucus Hypersecretion in a Murine, Elastase-Induced-COPD Model

Journal of Fungi, 2023
Inflammation and mucus hypersecretion are frequent pathology features of chronic respiratory diseases such as asthma and COPD. Selected bacteria, viruses and fungi may synergize as co-factors in aggravating disease by activating pathways that are able to
Diego A. Rojas, Carolina A. Ponce, Adriel Bustos, Vicente Cortés, Daniela Olivares, Sergio L. Vargas   +5 more
doaj   +1 more source

Glioma conditioned medium promotes glycolysis and phenotypic transformation in macrophages [PDF]

Jichu yixue yu linchuang
Objective To explore the effects and mechanisms involved in glioma conditioned medium for inducing glycolysis and oncogenic mediators in macrophages.
ZHANG Diya, LI Yunfan, GUO Hongjiang, QIU Jiaxing, WANG Yucheng, JU Rui, GUO Lei
doaj   +1 more source

Pyropia yezoensis glycoprotein promotes the M1 to M2 macrophage phenotypic switch via the STAT3 and STAT6 transcription factors

International Journal of Molecular Medicine, 2016
Macrophage polarization has been well documented. Macrophages can aquire two phenotypes, the pro-inflammatory M1 phenotype, and the anti-inflammatory and wound healing M2 phenotype. The M1 macrophage phenotype has been linked to metabolic disease and is also associated with cancer-related inflammation. Of note, macrophage polarization can be influenced
Jeong-Wook, Choi, Mi-Jin, Kwon, In-Hye, Kim, Young-Min, Kim, Min-Kyeong, Lee, Taek-Jeong, Nam   +5 more
openaire   +3 more sources

Chimeric IL‐6/4R‐LL37 Engineered Macrophages Achieve Synchronized Inflammation Control and Antimicrobial Defence in Sepsis

Advanced Science, EarlyView.
Engineered macrophages programmed in situ by LNP‐delivered IL‐6/4 fusion and LL37 mRNAs simultaneously dampen cytokine storm, promote M2‐like repair, and enhance direct bacterial killing in sepsis. This combinatorial strategy restores T cell and macrophage function, lowers organ bacterial burden, and improves survival, highlighting a precision, host ...
Tianyang Jie, Zheyu Zhang, Hao Zhang, Linke Bian, Penglong Zheng, Sijia Zhou, Minqi Wang, Mingyu Qu, Yufei Wang, Xinhua Qu, Bing Yue   +10 more
wiley   +1 more source

Suppression of signal transducer and activator of transcription 3-dependent B lymphocyte terminal differentiation by BCL-6 [PDF]

, 2000
Lymphocytes usually differentiate into effector cells within days after antigen exposure, except in germinal centers where terminal differentiation is delayed while somatic hypermutation creates high-affinity antibody mutants. Here we investigate whether
Peakman, LJ, Rajko Reljic (406091), Rajko Reljic, Reljic, R, Fearon, DT, Simon D. Wagner, Luke J. Peakman, Luke J. Peakman (7768292), Fearon, D T, Douglas T. Fearon, Wagner, S D, Wagner, SD, Simon D. Wagner (7633943), Douglas T. Fearon (7768295), Peakman, L J   +14 more
core   +1 more source

Th2 Cytokines Increase the Expression of Fibroblast Growth Factor 21 in the Liver

Cells, 2021
Interleukin-4 (IL-4) and IL-13 are the major T helper 2 (Th2) cytokines, and they are involved in the regulation of metabolism in the adipose tissue. The liver contains diverse innate and adaptive immune cells, but it remains to be determined whether Th2
Seul-Gi Kang, Seong-Eun Lee, Min-Jeong Choi, Joon-Young Chang, Jung-Tae Kim, Ben-Yuan Zhang, Yea-Eun Kang, Ju-Hee Lee, Hyon-Seung Yi, Minho Shong   +9 more
doaj   +1 more source

Bioadhesive‐Integrated 3D‐Printed Multilayer Scaffolds Secure a Mechanically‐Stable Osteoimmune Niche for Enhanced Bone Augmentation

Advanced Science, EarlyView.
A 3D‑printed multilayer adhesive scaffold, firmly anchored to bone defects by simple finger pressing, suppresses micromotion and secures mechanical stability of the osteogenic niche. This stabilization likely contributes to the enhanced bone augmentation by fostering a pro‑regenerative mechano‐immune profile—characterized by M2‑like macrophage ...
Delu Zhao, Qiuyi Li, Lingyun Wang, Chongao Zhang, Yutian Cheng, Shuang Liu, Fulan Wei, Zheqin Dong   +7 more
wiley   +1 more source

Functional analysis of the competence transcription factor ComK of Bacillus subtilis by characterization of truncation variants [PDF]

, 2005
The competence transcription factor ComK is the master regulator of competence development in Bacillus subtilis. In the regulatory pathway, ComK is involved in different interactions: (i) protein–DNA interactions to stimulate transcription of ComK ...
Andy-Mark W. H. Thunnissen, Thunnissen, Andy-Mark W.H.,, Thunnissen, A.M.W.H.; id_orcid, Oscar P. Kuipers, Fusetti, F., Fabrizia Fusetti, Hamoen, L.W, Susanna, Kim, Kim A. Susanna, Susanna, Kim Amé,, Kuipers, Oscar P.,, Susanna, Kim A.,, Fusetti, Fabrizia,, Kuipers, O.P., Hamoen, Leendert W.,, Susanna, Kim Amé, Kuipers, O.P.; id_orcid, Thunnissen, A.M.W.H., Leendert W. Hamoen   +18 more
core   +2 more sources

LPS Exposure in Early Life Protects Against Mucus Hypersecretion in Ovalbumin-Induced Asthma by Down-Regulation of the IL-13 and JAK-STAT6 Pathways

Cellular Physiology and Biochemistry, 2018
Background/Aims: Previous studies have shown that lipopolysaccharide (LPS) exposure may have a protective effect on asthma by reducing airway hyper-responsiveness, airway inflammation and serum IgE levels. However, there are few studies investigating the
Fengxia Ding, Bo Liu, Wenjing Zou, Daiyin Tian, Qubei Li, Jihong Dai, Zhengxiu Luo, Zhou Fu   +7 more
doaj   +1 more source

Signal Transducer and Activator of Transcription Factor 6 (Stat6)-deficient Mice Are Protected from Antigen-induced Airway Hyperresponsiveness and Mucus Production [PDF]

The Journal of Experimental Medicine, 1998
The pleiotropic cytokine interleukin 4 (IL-4) has been shown to regulate many processes thought to be important in the allergic diathesis. To determine the mechanism(s) by which IL-4 mediates allergic airway responses to inhaled allergens, we compared the effects of antigen sensitization and challenge on the development of allergic airway responses in ...
D, Kuperman, B, Schofield, M, Wills-Karp, M J, Grusby   +3 more
openaire   +2 more sources