Results 41 to 50 of about 4,534,601 (246)
BMC Immunology, 2022 Background Signal transducer and activator of transcription 6 (STAT6) is an intracelluar transcriotion factor and NLRP3 (Nod-like receptor containing a pyrin domain 3) is a component of NLRP3 inflammasome in pyroptotic cells.
Lu Hu +3 more
doaj +1 more source
The Significance of cGAS-STING Signaling in Response to Oncogenic Viruses. [PDF]
Cell Biochem FunctABSTRACT The cyclic GMP‐AMP synthase (cGAS)‐stimulator of interferon genes (STING) signaling pathway, as a key DNA sensor, plays a significant role in the regulation of innate immune responses. This pathway can be activated by sensing abnormal DNA, and is of great significance for resisting the invasion of pathogenic microorganisms and maintaining ...
Guo L, Li L, Wang F, Liu W, Zhang Y.
europepmc +2 more sources
Endocrine ConnectionsBackground: Signal transducer and activator of transcription 6 (STAT6) is an important nuclear transcription factor. Previous studies demonstrated that blocking STAT6 can ameliorate thyroid function by reducing serum T3 and T4.
Qian Yang +3 more
doaj +1 more source
IL-4 prevents adenosine-mediated immunoregulation by inhibiting CD39 expression
JCI Insight, 2022 The ectonucleotidase CD39 functions as a checkpoint in purinergic signaling on effector T cells. By depleting eATP and initiating the generation of adenosine, it impairs memory cell development and contributes to T cell exhaustion, thereby causing ...
Fengqin Fang +7 more
doaj +1 more source
Variable structure motifs for transcription factor binding sites [PDF]
, 2010 Background: Classically, models of DNA-transcription factor binding sites (TFBSs) have been based on relatively few known instances and have treated them as sites of fixed length using position weight matrices (PWMs).
Evans, Kenneth J. +17 more
core +6 more sources
Functional characterization of IL-13 receptor α2 gene promoter: a critical role of the transcription factor STAT6 for regulated expression [PDF]
Oncogene, 2003 Interleukin (IL)-4 and IL-13 are two structurally and functionally related cytokines that have overlapping but also distinct biological activities. One of the components of the IL-13 receptor, the alpha2 chain (IL-13Ralpha2), has been reported to downregulate the cell responsiveness to IL-13, without affecting IL-4 signaling.
Muriel D, David +2 more
openaire +2 more sources
Predominance of Th2 polarization by Vitamin D through a STAT6-dependent mechanism
Journal of Neuroinflammation, 2011 Background Vitamin D has several reported immunomodulatory properties including the reduced generation of pro-inflammatory CD4+ T helper 1 (Th1) cells and the increase in levels of the anti-inflammatory Th2 subset.
Wang Jianxiong +3 more
doaj +1 more source
Live-cell imaging of the association of STAT6-GFP with mitochondria. [PDF]
PLoS ONE, 2013 The transcription factor STAT3 has been previously reported to be associated with mitochondria. However, we have been unable to visualize an association of STAT3-GFP, STAT3-DsRed or STAT3-Flag with mitochondria in human Hep3B hepatocytes thus far even ...
Rasel Khan +4 more
doaj +1 more source
Using temporal correlation in factor analysis for reconstructing transcription factor activities [PDF]
, 2008 Two-level gene regulatory networks consist of the transcription factors (TFs) in the top level and their regulated genes in the second level. The expression profiles of the regulated genes are the observed high-throughput data given by experiments such ...
Wernisch, Lorenz +3 more
core +1 more source
Архивъ внутренней медицины, 2018 The study discusses the relationship of thiol concentrations in intercellular fluid with the level of peripheral blood mononuclear cells (MNCs) in convalescents with community-acquired pneumonia (CAP) components MAPK/SAPK and JAK/STAT-signaling pathways,
S. S. Bondar +4 more
doaj +1 more source