Results 21 to 30 of about 4,534,601 (246)

Additional file 1 of Transcription factor signal transducer and activator of transcription 6 (STAT6) is an inhibitory factor for adult myogenesis

, 2021
Additional file 1: Figure S1. Differentiation index in STAT6-overexpressed and STAT6-inhibited cells. (A) Differentiation index in the Ad-Ctrl and Ad-STAT6 treatments. n = 5. *p < .05 vs. Ad-Ctrl. Images in Fig. 2 were used for analysis. (B) Differentiation index in the Ctrl and shSTAT6 treatments. n = 5. *p < .05 vs. Ctrl. Images in Fig.
Kurosaka, Mitsutoshi, Ogura, Yuji, Sato, Shuichi, Kohda, Kazuhisa, Funabashi, Toshiya   +4 more
openaire   +1 more source

Reprogramming of lysosomal gene expression by interleukin-4 and Stat6. [PDF]

, 2013
BACKGROUND: Lysosomes play important roles in multiple aspects of physiology, but the problem of how the transcription of lysosomal genes is coordinated remains incompletely understood.
Meira, LB, Czimmerer, Z, Louise M Brignull, Hafida Saidi, Saidi, H, Bartlett, Nathan W., Bence Daniel, Nagy, László, Villela, Izabel, Nohturfft, A, Brignull, LM, Izabel Villela, Johnston, Sebastian L., Meira, Lisiane B., Villela, I, Axel Nohturfft, Nohturfft, Axel, Zsolt Czimmerer, Brignull, L. M., Nathan W Bartlett, Saidi, H., Dániel, Bence, Czimmerer, Zsolt, Daniel, B, Lisiane B Meira, Saidi, Hafida, Brignull, Louise M., Nagy, L, Villela, I., Laszlo Nagy, Bartlett, NW, Johnston, SL, Sebastian L Johnston   +32 more
core   +1 more source

ADP-ribosylation: An emerging regulator of the epigenome. [PDF]

Mol Oncol
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Camacho CV, Liu C, Kraus WL.
europepmc   +2 more sources

IL-13 mediates collagen deposition via STAT6 and microRNA-135b: a role for epigenetics [PDF]

, 2016
Systemic sclerosis is an autoimmune connective tissue disease in which T cells play a prominent role. We and others have previously demonstrated a role for T cell-derived IL-13 in mediating the induction of collagen in dermal fibroblasts and that ...
van Laar, Jacob, Van Laar, Jacob M., O'Reilly, Steven, Fullard, Nicola, Ciechomska, Marzena, Przyborski, Stefan, van Laar, J.M., O’Reilly, S., Fullard, N., Przyborski, S., Ciechomska, M.   +10 more
core   +2 more sources

Small Interfering RNA against Transcription Factor STAT6 Inhibits Allergic Airway Inflammation and Hyperreactivity in Mice [PDF]

The Journal of Immunology, 2009
Abstract In the context of allergic immune responses, activation of STAT6 is pivotal for Th2-mediated IgE production and development of airway inflammation and hyperreactivity. We analyzed whether gene silencing of STAT6 expression by RNA interference was able to suppress allergen-induced immune and airway responses.
Yasemin, Darcan-Nicolaisen, Holger, Meinicke, Gabriele, Fels, Olga, Hegend, Annekathrin, Haberland, Anja, Kühl, Christoph, Loddenkemper, Martin, Witzenrath, Stefanie, Kube, Wolfgang, Henke, Eckard, Hamelmann   +10 more
openaire   +2 more sources

Data integration for identification of important transcription factors of STAT6-mediated cell fate decisions

Genetics and Molecular Research, 2016
Data integration has become a useful strategy for uncovering new insights into complex biological networks. We studied whether this approach can help to delineate the signal transducer and activator of transcription 6 (STAT6)-mediated transcriptional network driving T helper (Th) 2 cell fate decisions.
Jargosch, M., Kroeger, S., Gralinska, E., Klotz, Ulrike, Fang, Z., Chen, W., Leser, U., Selbig, Joachim (Prof. Dr.), Groth, Detlef (Dr.), Baumgrass, Ria   +9 more
openaire   +3 more sources

The transcription factor EGR2 is the molecular linchpin connecting STAT6 activation to the late, stable epigenomic program of alternative macrophage polarization [PDF]

Genes & Development, 2020
Macrophages polarize into functionally distinct subtypes while responding to microenvironmental cues. The identity of proximal transcription factors (TFs) downstream from the polarization signals are known, but their activity is typically transient, failing to explain the long-term, stable epigenomic programs developed.
Daniel, B., Czimmerer, Z., Halasz, L., Boto, P., Kolostyak, Z., Poliska, S., Berger, W.K., Tzerpos, P., Nagy, G., Horvath, A., Hajas, G., Cseh, T., Nagy, A., Sauer, S., Francois-Deleuze, J., Szatmari, I., Bacsi, A., Nagy, L.   +17 more
openaire   +3 more sources

STAT6 expression in T cells, alveolar macrophages and bronchial biopsies of normal and asthmatic subjects

Journal of Inflammation, 2012
Background Asthma is characterised by increased numbers of Th2-like cells in the airways and IgE secretion. Generation of Th2 cells requires interleukin (IL)-4 and IL-13 acting through their specific receptors and activating the transcription factor ...
Tomita Katsuyuki, Caramori Gaetano, Ito Kazuhiro, Sano Hiroyuki, Lim Sam, Oates Timothy, Cosio Borja, Chung K Fan, Tohda Yuji, Barnes Peter J, Adcock Ian M   +10 more
doaj   +1 more source

Activation of STAT6 by intranasal allergens correlated with the development of eosinophilic chronic rhinosinusitis in a mouse model

International Journal of Immunopathology and Pharmacology, 2022
Eosinophilic chronic rhinosinusitis (ECRS) is a chronic inflammatory disease characterized by prominent eosinophilic infiltration along with a T-helper-2 (Th2) response. It has been well documented that signal transducer and activator of transcription 6 (
Hongqi Wei, Longjiang Xu, Peng Sun, Hongyu Xing, Zhengwen Zhu, Jisheng Liu   +5 more
doaj   +1 more source

p160/SRC/NCoA coactivators form complexes via specific interaction of their PAS-B domain with the CID/AD1 domain [PDF]

, 2008
Transcriptional activation involves the ordered recruitment of coactivators via direct interactions between distinct binding domains and recognition motifs.
Coudevylle, N., Pfitzner, E., Muenz, Tobias, Pfitzner, Edith, Becker, Stefan, Coudevylle, Nicolas, Münz, Tobias, Lodrini, M., Becker, S., Munz, T., Griesinger, C., Lodrini, Marco, Griesinger, Christian   +12 more
core   +1 more source