Results 1 to 10 of about 19,239 (120)

STAT6 Signaling Mediates PPARγ Activation and Resolution of Acute Sterile Inflammation in Mice

Cells, 2021
The signal transducer and activator of transcription 6 (STAT6) transcription factor promotes activation of the peroxisome proliferator-activated receptor gamma (PPARγ) pathway in macrophages.
Ye-JI Lee, Bo-Min Kim, Young-Ho Ahn, Ji Ha Choi, Youn-Hee Choi, Jihee Lee Kang   +5 more
doaj   +1 more source

Transcription factor signal transducer and activator of transcription 6 (STAT6) is an inhibitory factor for adult myogenesis

Skeletal Muscle, 2021
Background The signal transducer and activator of transcription 6 (STAT6) transcription factor plays a vitally important role in immune cells, where it is activated mainly by interleukin-4 (IL-4).
Mitsutoshi Kurosaka, Yuji Ogura, Shuichi Sato, Kazuhisa Kohda, Toshiya Funabashi   +4 more
doaj   +1 more source

Th2-dependent STAT6-regulated genes in intestinal epithelial cells mediate larval trapping during secondary Heligmosomoides polygyrus bakeri infection.

PLoS Pathogens, 2023
Gastrointestinal helminths are a major health threat worldwide. Alternatively activated macrophages (AAMs) have been shown to contribute to host protection during secondary helminth infections. AAMs express effector molecules that depend on activation of
Stefanie Westermann, Christoph Schubart, Axel Dietschmann, Kirstin Castiglione, Daniel Radtke, David Voehringer   +5 more
doaj   +1 more source

Promotion of a synthetic degradation of activated STAT6 by PARP-1 inhibition: roles of poly(ADP-ribosyl)ation, calpains and autophagy

Journal of Translational Medicine, 2022
Background We reported that PARP-1 regulates genes whose products are crucial for asthma, in part, by controlling STAT6 integrity speculatively through a calpain-dependent mechanism.
Jeffrey Wang, Mohamed A. Ghonim, Salome V. Ibba, Hanh H. Luu, Yucel Aydin, Peter A. Greer, A. Hamid Boulares   +6 more
doaj   +1 more source

Hookworms dynamically respond to loss of Type 2 immune pressure.

PLoS Pathogens, 2023
The impact of the host immune environment on parasite transcription and fitness is currently unknown. It is widely held that hookworm infections have an immunomodulatory impact on the host, but whether the converse is true remains unclear.
Annabel A Ferguson, Juan M Inclan-Rico, Dihong Lu, Sarah D Bobardt, LiYin Hung, Quentin Gouil, Louise Baker, Matthew E Ritchie, Aaron R Jex, Erich M Schwarz, Heather L Rossi, Meera G Nair, Adler R Dillman, De'Broski R Herbert   +13 more
doaj   +1 more source

Long-Acting Beta Agonists Enhance Allergic Airway Disease. [PDF]

PLoS ONE, 2015
Asthma is one of the most common of medical illnesses and is treated in part by drugs that activate the beta-2-adrenoceptor (β2-AR) to dilate obstructed airways. Such drugs include long acting beta agonists (LABAs) that are paradoxically linked to excess
John M Knight, Garbo Mak, Joanne Shaw, Paul Porter, Catherine McDermott, Luz Roberts, Ran You, Xiaoyi Yuan, Valentine O Millien, Yuping Qian, Li-Zhen Song, Vincent Frazier, Choel Kim, Jeong Joo Kim, Richard A Bond, Joshua D Milner, Yuan Zhang, Pijus K Mandal, Amber Luong, Farrah Kheradmand, John S McMurray, David B Corry   +21 more
doaj   +1 more source

Loss of STAT6 leads to anchorage-independent growth and trastuzumab resistance in HER2+ breast cancer cells.

PLoS ONE, 2020
Approximately 20% of breast cancers are HER2-positive. Trastuzumab has improved patient outcomes significantly for these cancers. However, acquired resistance remains a major hurdle in the clinical management of these patients.
Molly DiScala, Matthew S Najor, Timothy Yung, Deri Morgan, Abde M Abukhdeir, Melody A Cobleigh   +5 more
doaj   +1 more source

A STAT6 Inhibitor AS1517499 Reduces Preventive Effects of Apoptotic Cell Instillation on Bleomycin-Induced Lung Fibrosis by Suppressing PPARγ

Cellular Physiology and Biochemistry, 2018
Background/Aims: The signal transducer and activator of transcription 6 (STAT6) transcription factor mediates PPARγ-regulated gene expression in macrophages.
Myeong-Joo Kim, Ye-Ji Lee, Young-So Yoon, Jae H. Lim, Eun-Mi Park, Young H. Chong, Jihee Lee Kang   +6 more
doaj   +1 more source

Bixin Protects Against Kidney Interstitial Fibrosis Through Promoting STAT6 Degradation

Frontiers in Cell and Developmental Biology, 2020
Bixin, a natural carotenoid extracted from the seeds of Bixa orellana, has antioxidant and anti-inflammation effects. However, the pharmacological effects and underlying mechanisms of bixin in kidney interstitial fibrosis remain unknown.
Jianzhong Li, Jianzhong Li, Youjing Yang, Shuhui Wei, Ling Chen, Lian Xue, Hailin Tian, Shasha Tao, Shasha Tao   +8 more
doaj   +1 more source

LncGBP9/miR-34a axis drives macrophages toward a phenotype conducive for spinal cord injury repair via STAT1/STAT6 and SOCS3

Journal of Neuroinflammation, 2020
Background Acute spinal cord injury (SCI) could cause mainly two types of pathological sequelae, the primary mechanical injury, and the secondary injury.
Jiahui Zhou, Zhiyue Li, Tianding Wu, Qun Zhao, Qiancheng Zhao, Yong Cao   +5 more
doaj   +1 more source