Results 31 to 40 of about 4,534,601 (246)

STAT6 Mediates Interleukin-4 Growth Inhibition in Human Breast Cancer Cells

Neoplasia: An International Journal for Oncology Research, 2002
In addition to acting as a hematopoietic growth factor, interleukin-4 (IL-4) inhibits growth of some transformed cells in vitro and in vivo. In this study, we show that insulin receptor substrate (IRS)-1, IRS-2, and signal transducer and activator of ...
Jennifer L. Gooch, Barbara Christy, Douglas Yee   +2 more
doaj   +1 more source

PPARγ as an E3 Ubiquitin-Ligase Impedes Phosphate-Stat6 Stability and Promotes Prostaglandins E2-Mediated Inhibition of IgE Production in Asthma

Frontiers in Immunology, 2020
Increased serum IgE level is one of the features of allergic asthma. It is reported that IgE production can be enhanced by E-prostanoid 2 (EP2) receptor of prostaglandin E2 (PGE2); however, whether E-prostanoid 4 (EP4) receptor (encoded by Ptger4) has a ...
Jia Wu, Yan Wang, Yu Zhou, Yuqing Wang, Xiaowan Sun, Ye Zhao, Youfei Guan, Yu Zhang, Yu Zhang, Wei Wang   +9 more
doaj   +1 more source

INTERACTION OF TRANSCRIPTION FACTORS PAX-5 AND STAT6 IN PATHOGENESIS OF ALLERGIC BRONCHIAL ASTHMA

Medical Immunology (Russia), 2014
The aim of this work was to study an opportunity of coordinated expression of PAX-5 and STAT6 in bronchial asthma (BA) development. 35 healthy controls, 83 patients with allergic bronchial asthma (ABA) and 63 patients with nonallergic bronchial asthma (NABA) o different severity were observed.
V. N. Mineev, L. N. Sorokina, M. A. Nyoma, A. V. Eremeeva   +3 more
openaire   +3 more sources

Regulation of μ-Opioid Receptor Gene Transcription by Interleukin-4 and Influence of an Allelic Variation within a STAT6 Transcription Factor Binding Site [PDF]

Journal of Biological Chemistry, 2001
Morphine and the endogenous opioid peptide beta-endorphin exert neuromodulatory as well as immunomodulatory effects, which are transduced by mu-opioid receptors. In this report we show that stimulation with interleukin-4 induces mu-opioid receptor transcripts in human primary blood cells (T cells and polymorphonuclear leukocytes), immune cell lines ...
Kraus, Jürgen, Börner, Christine, Giannini, Elisa, Hickfang, Kathrin, Braun, Holger, Mayer, Peter, Hoehe, Margret R., Ambrosch, Andreas, König, Wolfgang, Höllt, Volker   +9 more
openaire   +4 more sources

Global Analysis of Dynamic Epigenetic Marking and Transcriptional Regulation Underlying T-Cell Lineage Commitment [PDF]

, 2012
T-cell lineage specification and commitment success depends on precise temporal induction of T-lineage specific genes, as well as repression of lineage-inappropriate programs. After entry into the thymus, T-cell progenitors still retain inherited lineage
Zhang, Jingli A.
core   +1 more source

Nucleocytoplasmic Transport of the Transcription Factor STAT6 [PDF]

, 2010
Signal Transducer and Activator of Transcription 6 (STAT6) is a member of the STAT family of transcription factors that regulate cytokine signaling pathways.
Chen, Hui-Chen
core   +1 more source

Signal transducers and activators of transcription 6 (Stat6) variants in childhood and adult asthma

Allergology International, 2004
Background: Signal transducers and activators of transcription 6 (Stat6) is a key transcription factor involved in interleukin (IL)-4 and IL-1 3-mediated biological responses.
Michiko Suzuki, Hirokazu Arakawa, Yasuko Kobayashi, Kazushi Tamura, Hiroyuki Mochizuki, Kenichi Tokuyama, Mayumi Tamari, X.-Q. Mao, Taro Shirakawa, Kenji Izuhara, Akihiro Morikawa   +10 more
doaj   +1 more source

Bayesian model-based inference of transcription factor activity [PDF]

, 2007
<b>Background:</b> In many approaches to the inference and modeling of regulatory interactions using microarray data, the expression of the gene coding for the transcription factor is considered to be an accurate surrogate for the true ...
Rogers, S, Girolami, M, Rogers, Simon, Girolami, Mark, Khanin, R, Khanin, Raya   +5 more
core   +1 more source

Molecular characterization of regulatory polymorphisms in the promoter region of the STAT6 gene in a Gabonese population

Memorias do Instituto Oswaldo Cruz, 2011
Parasites remain competent invaders of host immunity. Their invasion strategies have proven to impact immunorelevant genes leading to diversity among gene families. We focussed on signal transducer and activator of transcription (STAT6) factor that plays
Thirumalaisamy Palanichamy Velavan, Silke Bechlars, Jürgen Tomiuk, Peter G Kremsner, Jürgen FJ Kun   +4 more
doaj   +1 more source

An R2R3 MYB transcription factor associated with regulation of the anthocyanin biosynthetic pathway in Rosaceae [PDF]

, 2010
Background The control of plant anthocyanin accumulation is via transcriptional regulation of the genes encoding the biosynthetic enzymes. A key activator appears to be an R2R3 MYB transcription factor.
Wang, Kui-Lin, Kortstee, A.J., Tony K McGhie, McGhie Tony K, Hellens, R.P., Espley Richard V, Hellens Roger P, Grafton, Karryn, Espley, Richard V., Karryn Grafton, Karunairetnam, Sakuntala, Andrew C Allan, Kortstee, Anne, Roger P Hellens, Allan, A.C., Allan, Andrew C., McGhie, T.K., Richard V Espley, Kortstee Anne, Allan Andrew C, Espley, R.V., Sakuntala Karunairetnam, Karunairetnam Sakuntala, Grafton Karryn, McGhie, Tony K., Lin-Wang Kui, Bolitho, Karen, Karen Bolitho, Anne Kortstee, Bolitho Karen, Hellens, Roger P., Lin-Wang, Kui, Kui Lin-Wang   +32 more
core   +2 more sources