Results 241 to 250 of about 207,642 (299)

Prostate Cancer, JAK/STAT3 Dysregulation, and Flavonoids: Is There a Possible Link? [PDF]

Int J Mol Sci
Uivarosi V, Miricescu D, Vacaroiu IA, Spinu DA, Stefani C, Stanciu S, Nica RI, Stanescu-Spinu II, Badoiu SC, Nica S, Jinga V.   +10 more
europepmc   +1 more source

Neuroprotective effects of ursodeoxycholic acid in Parkinson's disease and Alzheimer's disease

Neuroprotection, EarlyView.
In Parkinson's disease (PD) and Alzheimer's disease (AD), various shared pathological mechanisms exist. UDCA has been shown to exert neuroprotective effects in preclinical and clinical studies. Such effects include the mitigation of neuroinflammation as well as rescue effects on mitochondrial dysfunction, oxidative stress, impaired autophagy, and ...
Ashley En Yi Chong, Andrew Octavian Sasmita, Rhun Yian Koh, Anna Pick Kiong Ling   +3 more
wiley   +1 more source

Dietary <i>Lactobacillus plantarum</i> Supplementation Improves Growth Performance and Antioxidant Status and Upregulates Genes Related to the Toll/Imd and JAK-STAT Signaling Pathways in Red Claw Crayfish (<i>Cherax quadricarinatus</i>). [PDF]

Animals (Basel)
Zhang Q, Du C, Zhao J, Li L, Ren J, Tong T, Wang D, Wang R, Liu Y, Yang H.   +9 more
europepmc   +1 more source

Innate immunity shapes the persistent transmission of plant viruses by insect vectors

New Plant Protection, EarlyView.
In this review, we focus on two key aspects of the virus–vector interplay: (1) persistently transmitted viruses utilize host factors to overcome transmission barriers; and (2) molecular recognition activates antiviral immunity and subsequent viral counter‐defense. Understanding these interactions offers critical insights for developing novel strategies
Gang Lu, Chuanxi Zhang, Junmin Li
wiley   +1 more source

Successful treatment of cutaneous small-vessel vasculitis with upadacitinib: a Case Report. [PDF]

Front Med (Lausanne)
Li X, Wu Z, Zhao X, Liu L, Li H, Zhang G, Zhu Q.   +6 more
europepmc   +1 more source

Cancer‐Associated Fibroblasts: Central Players in the Plastic Pancreatic Cancer Microenvironment and Therapeutic Targeting

Organ Medicine, EarlyView.
Cancer‐associated fibroblasts (CAFs) are key regulators of the pancreatic tumor microenvironment. Through metabolic reprogramming, CAFs support tumor growth by providing nutrients and remodeling extracellular matrix. CAF heterogeneity, including myCAF, iCAF, and apCAF subsets, contributes to immune modulation and therapeutic resistance.
Ziyi Qin, Jinyang Ma, Rui Ju, Lei Guo
wiley   +1 more source

Impact of rare JAK/STAT germline mutations on vaccination-induced innate immune responses in a Tyrolian population. [PDF]

Int J Biol Sci
Hennighausen L, Cho G, Lee SG, Caf Y, Kim J, Knabl L, Furth PA, Lee HK.   +7 more
europepmc   +1 more source

Investigation of the Mechanism of Cinnamaldehyde in Irritable Bowel Syndrome Based via Network Pharmacology, Molecular Docking, and Animal Experiments

Pediatric Discovery, EarlyView.
Through network pharmacology and molecular docking, it has been discovered that CA can target MAOB, among other proteins, to exert a therapeutic effect in IBS. In vivo, CA lowered visceral hypersensitivity, anxiety and depression‐like behaviors, and fecal water content, highlighting its therapeutic potential for IBS via anti‐inflammatory pathways ...
Qingyang Yu, Boqing Xu, Chunfang Dai, Yayan Pang, Zhifang Dong   +4 more
wiley   +1 more source

Exploring the Complexities of TGF-β Signaling in Keloids: Beyond the Classical Smad Pathway. [PDF]

Int J Mol Sci
Mo J, Huang H, Zhu B, Liao R, Li W, Zhang Y.   +5 more
europepmc   +1 more source

The N‐Glycome to Differentiate Mesenchymal Stem Cells Upon Chondrogenic Differentiation, Dedifferentiation, and Senescence

PROTEOMICS, EarlyView.
ABSTRACT Mesenchymal stem cells (MSCs) are adult stem cells able to self‐renewal or differentiation into different cell types, including chondrocytes. N‐Glycans are post‐translational modifications of glycoproteins that contribute to vital cell functions.
Houda Montacir, Karina Biskup, Michael Sittinger, Rudolf Tauber, Véronique Blanchard   +4 more
wiley   +1 more source