Results 251 to 260 of about 207,642 (299)

IQDMA disrupts STAT5 nuclear transport through CDC42-PAK2 axis collapse in cutaneous T-cell lymphoma. [PDF]

Front Immunol
Dey S, Sorger H, Schlederer M, Perchthaler I, Metzelder M, Kenner L, Moriggl R, Wolf P.   +7 more
europepmc   +1 more source

Heritability and Transcriptional Impact of JAK3, STAT5A and STAT6 Variants in a Tyrolean Family. [PDF]

Int J Mol Sci
Lee HK, Haikarainen T, Caf Y, Furth PA, Knabl L, Silvennoinen O, Hennighausen L.   +6 more
europepmc   +1 more source

Inhibition of the JAK/STAT Signaling Pathway Suggests a Protective Effect against Acantholysis in Pemphigus. [PDF]

Inflammation
Solimani F, Holstein J, Meier K, Rochin LMC, Mesas-Fernandez A, Jiang YF, Feoktistova MA, Schmidt MF, Yazdi AS, Hilke FJ, Ghoreschi K.   +10 more
europepmc   +1 more source

Microglial Innate Immune Memory: Implications and Research Advances in Central Nervous System Disorders. [PDF]

Curr Issues Mol Biol
Song Y, Shu S, Zeng X, Xia M, Liu J, Li L.   +5 more
europepmc   +1 more source

Fusion Molecules Between the STAT5b Inhibitor Stafib-2-CR and a Cereblon Ligand. [PDF]

ChemistryOpen
Münzel T, Seidenstücker KC, Protzel C, Berg A, Berg T.   +4 more
europepmc   +1 more source

Activation of STAT transcription factors in oncogenic tyrosine kinase signaling

Journal of Biomedical Science, 1998
Signal transducers and activators of transcription (STATs) are cytoplasmic transcription factors that translocate to the nucleus and regulate gene expression in response to cytokine and growth factor stimulation. Emerging evidence indicates that STAT signaling is also frequently activated by oncogenes and in tumor cells. Constitutive activation of STAT
Ricardo Garcia
exaly   +3 more sources

Activated Stat Related Transcription Factors in Acute Leukemia [PDF]

Leukemia and Lymphoma, 1997
Cell proliferation and differentiation are under the control of cytokines and growth factors. Different signaling pathways are involved in the transmission of a specific signal through successive phosphorylation and dephosphorylation of proteins leading to gene transcription necessary for growth and differentiation.
Françoise Debierre-Grockiego, Fabrice Gouilleux   +1 more
exaly   +3 more sources

Targeting Oncogenic Transcription Factors: Therapeutic Implications of Endogenous STAT Inhibitors [PDF]

Trends in Cancer, 2017
Misregulation of transcription factors, including signal transducer and activator of transcription (STAT) proteins, leads to inappropriate gene expression patterns that can promote tumor initiation and progression. Under physiologic conditions, STAT signaling is stimulus dependent and tightly regulated by endogenous inhibitors, namely, suppressor of ...
David A Frank
exaly   +3 more sources

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Nucleocytoplasmic shuttling of STAT transcription factors

European Journal of Biochemistry, 2004
The signal transducer and activator of transcription (STAT) proteins have initially been described as cytoplasmic proteins that enter the nucleus only after cytokine treatment of cells. Contrary to this assumption, it was demonstrated that STATs are constantly shuttling between nucleus and cytoplasm irrespective of cytokine stimulation.
Thomas, Meyer, Uwe, Vinkemeier
openaire   +2 more sources