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Transcription factor STAT enhanced antimicrobial activities in Bombyx mori
International Journal of Biological MacromoleculesSTAT, a transcription factor in the JAK/STAT signaling pathway, regulates immune response to pathogens. In the silkworm (Bombyx mori), STAT exists as two split-forms, STAT-S and STAT-L. However, the role of STAT in silkworm immunity remains unclear. Our purpose was to investigate the effect of STAT on the expression of antimicrobial peptide (AMP) genes
Li, Zhou +7 more
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STAT Transcription Factors in T Cell Control of Health and Disease
2017The Jak-STAT pathway is one of many pleiotropic signaling pathways that plays an important role in organismal development and in response to changing environmental cues. As a key signaling cascade for cytokines and growth factors, Jak-STAT plays central role in the innate and adaptive immune system.
R, Goswami, M H, Kaplan
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Ikaros zinc finger transcription factors as novel regulators of STAT factor activity
The Journal of Immunology, 2019Abstract Cytokine signaling is important for the differentiation and function of a number of cell types, including lymphocyte populations. One mechanism by which cytokine signals are propagated is via phosphorylation-mediated activation of Signal Transducer and Activator of Transcription (STAT) factors, which directly regulate cell type ...
Kaitlin Read +4 more
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DNA Recognition by NFκB and STAT Transcription Factors
2001The regulated transcription of genes is an important mechanism by which cells control gene expression in response to changing environmental conditions and developmental and apoptotic signals. External and internal cellular signals lead to the activation of transcription factors, which bind to sequence-specific DNA-response elements and stimulate ...
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Current Genomics, 2004
The signal transducers and activators of transcription (STATs) are a family of transcription factors which were originally identified on the basis of their ability to transduced a Signal From a cellular receptor into the nucleus and modulate the transcription of specific genes.
D. Latchman, A. Stephanou
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The signal transducers and activators of transcription (STATs) are a family of transcription factors which were originally identified on the basis of their ability to transduced a Signal From a cellular receptor into the nucleus and modulate the transcription of specific genes.
D. Latchman, A. Stephanou
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GPx2 Induction Is Mediated Through STAT Transcription Factors During Acute Colitis
Inflammatory Bowel Diseases, 2015The selenoprotein glutathione peroxidase 2 (GPx2) is highly expressed in the gastrointestinal epithelium. During inflammatory bowel disease and colorectal cancer, GPx2 expression is enhanced.We analyzed GPx2 expression and transcriptional regulation during the different phases of dextran sulfate sodium (DSS)-induced colitis in mice and in cytokine ...
Franziska, Hiller +4 more
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Expression and Activation of STAT Transcription Factors in Breast Cancer
1998Abstract : Endocrine therapy has proven a valuable approach to the treatment of breast cancer. In particular, antiestrogens have demonstrated significant improvement in survival rates, and have recently been shown to prevent breast cancer development in women in high-risk populations.
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Transcriptional regulation of the heat shock protein genes by STAT family transcription factors.
Gene expression, 1999We have previously demonstrated that interleukin-6 (IL-6) increases the levels of the heat shock protein 90 (Hsp90) and activates the Hsp90beta promoter via the IL-6-activated transcription factors NF-IL6 and STAT-3. In addition, interferon-gamma (IFN-gamma) treatment increases the levels of Hsp70 and Hsp90 and also enhances the activity of the Hsp70 ...
A, Stephanou, D S, Latchman
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DNA and Cell Biology, 2002
Nerve growth factor (NGF) has an inhibitory effect while inflammatory cytokines may stimulate herpes simplex virus (HSV) reactivation. NGF binds to its receptor trkA on terminal axons and signals the neuron cell body in the ganglion. Many cytokines may also signal neurons through their specific receptors, affecting STAT transcription factors within the
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Nerve growth factor (NGF) has an inhibitory effect while inflammatory cytokines may stimulate herpes simplex virus (HSV) reactivation. NGF binds to its receptor trkA on terminal axons and signals the neuron cell body in the ganglion. Many cytokines may also signal neurons through their specific receptors, affecting STAT transcription factors within the
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Review for "Transcriptional programing of T cell metabolism by STAT family transcription factors"
2023+6 more sources