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STAT family of transcription factors in cytokine-mediated biological responses
Cytokine and Growth Factor Reviews, 2000STAT (signal transducers and activators of transcription) family, consisting of seven members, is involved in cytokine signal transduction. Biological roles of each STAT family protein have now been elucidated through studies of gene targeted mice. Stat1 knockout mice are defective in interferon-mediated functions.
Kiyoshi Takeda, Shizuo Akira
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STAT transcription factors in normal and cancer stem cells
Advances in Biological Regulation, 2014Signal transducer and activator of transcription proteins (STATs) play vital roles in the regulation of cellular proliferation and survival in normal hematopoietic cells, including hematopoietic stem cells. However, aberrant activation of STATs is commonly observed in a number of hematologic malignancies, and recent studies indicate that targeting of ...
Kathleen A, Dorritie +2 more
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The evolutionary divergence of STAT transcription factor in different Anopheles species
Gene, 2017Anopheles mosquito transmits Plasmodium, the malaria causing parasite. Different species of Anopheles mosquito dominate in a particular geographical location and are capable of transmitting specific strains of Plasmodium. It is important to understand the biology of different anophelines to control the parasite transmission.
Kuldeep Gupta +2 more
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Leukemia, 2013
Signal transducer and activator of transcription (STAT) proteins comprise a family of transcription factors that are activated by cytokines, hormones and growth factors. The activation of STAT proteins plays a key role in the production of mature hematopoietic cells via effects on cellular proliferation, survival and lineage-specific differentiation ...
James A McCubrey
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Signal transducer and activator of transcription (STAT) proteins comprise a family of transcription factors that are activated by cytokines, hormones and growth factors. The activation of STAT proteins plays a key role in the production of mature hematopoietic cells via effects on cellular proliferation, survival and lineage-specific differentiation ...
James A McCubrey
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STAT transcription factor is indispensable for oogenesis in silkworm
International Journal of Biological MacromoleculesSignal Transducer and Activator of Transcription (STAT) proteins represent a critical transcription factor family with multifaceted roles in diverse fundamental eukaryotic processes. In Drosophila, STAT exerts a pivotal regulatory influence on oogenesis, governing the early differentiation of follicular cells and ensuring proper encapsulation of germ ...
Shiyuan, Wang +8 more
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STFs: STAT-Containing Transcription Factors
1996The term signal transducing factor (STF) was coined recently257,259 to draw together an apparently diverse group of transcription factor complexes which are elicited following stimulation of cytokine receptors and PTK receptors.257 These STFs were originally revealed by dint of their ability to bind to specific DNA elements (known as STAT-binding ...
Andrew F. Wilks, Ailsa G. Harpur
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A Role for STAT Family Transcription Factors in Myeloid Differentiation
1996STAT family transcription factors regulate gene expression in response to a wide variety of cytokines. A transcription factor designated differentiation-induced factor (DIF), activated by treatment of myeloid cells with the differentiating agents interferon-gamma (IFN-gamma), granulocyte-macrophage colony-stimulating factor (GM-CSF), colony-stimulating
F, Barahmand-pour +4 more
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Stat Transcription Factors in Mammary Gland Development and Tumorigenesis
Journal of Mammary Gland Biology and Neoplasia, 2001Two members of the Stat family of transcription factors play a vital role in mouse mammary gland development. Stat5a was originally described as a regulator of milk protein gene expression and was subsequently shown to be essential for mammary development and lactogenesis.
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An Interleukin-4-Induced Transcription Factor: IL-4 Stat
Science, 1994Interleukin-4 (IL-4) is an immunomodulatory cytokine secreted by activated T lymphocytes, basophils, and mast cells. It plays an important role in modulating the balance of T helper (Th) cell subsets, favoring expansion of the Th2 lineage relative to Th1.
J, Hou +5 more
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Assessing Phosphorylation of STAT Transcription Factors in Mouse Innate Lymphoid Cells
2020Innate lymphoid cells (ILCs) ensure protection against pathogens by quickly reacting to the alterations of the cytokine milieu taking place upon infection. More than 50 cytokines and growth factors activate the Janus kinases (JAKs), leading to phosphorylation of members of the signal transducer and activator of transcription (STAT) family.
Scarno G. +4 more
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