Results 41 to 50 of about 17,928 (220)

A Reactive Antagonist Strategy: Cysteine‐Directed Covalent Molecular Glue in Plant Hormone Receptor Regulation

Advanced Science, EarlyView.
The plant hormone jasmonate is perceived by COI1‐JAZ co‐receptors comprising a single F‐box protein COI1 and multiple JAZ repressors with overlapping functions, complicating genetic analysis. We present a reactive antagonist (RA) strategy that selectively promotes COI1 binding to a cysteine‐engineered JAZ variant while blocking wild‐type JAZs, enabling
Minoru Ueda, Kotaro Matsumoto, Takao Nomura, Yousuke Takaoka, Taichi Okumura, Wataru Kozaki, Hikaru Hoshikawa, Yuho Nishizato, Andrea Chini, Roberto Solano, Katsumi Maenaka   +10 more
wiley   +1 more source

Accelerating Primary Screening of USP8 Inhibitors from Drug Repurposing Databases with Tree‐Based Machine Learning

Advanced Intelligent Discovery, EarlyView.
This study introduces a tree‐based machine learning approach to accelerate USP8 inhibitor discovery. The best‐performing model identified 100 high‐confidence repurposable compounds, half already approved or in clinical trials, and uncovered novel scaffolds not previously studied. These findings offer a solid foundation for rapid experimental follow‐up,
Yik Kwong Ng, Sharon Ai Er Lam, Wei Chun Lim, Hannah Hui Min Toh, Shi Jun Ang   +4 more
wiley   +1 more source

A new bonded silica based on an amino acid derivative as a TLC stationary phase to solve nitrophenol structural isomerism and ibuprofen stereoisomerism

Future Journal of Pharmaceutical Sciences, 2020
Background Many amino acids and their derivatives have been used previously as chiral selectors in thin layer chromatography. Herein, we reported the synthesis, characterization, and chromatographic evaluation of a new modified stationary phase based on (
Mouhammad Abu Rasheed, Ahmad Alshaghel, Amir Alhaj Sakur   +2 more
doaj   +1 more source

Scientific Opinion on Flavouring Group Evaluation 11, Revision 3 (FGE.11Rev3): Aliphatic dialcohols, diketones, and hydroxyketones from chemical groups 8 and 10

EFSA Journal, 2014
The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to evaluate 11 flavouring substances in the Flavouring Group Evaluation 11, Revision 3, using the Procedure in Commission ...
EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids
doaj   +1 more source

Stereoisomerism‐controlled Packing in Ladder‐type Indacenodithieno[3,2‐b]thiophene Crystals

Aggregate
Stereochemistry is a potent way to direct the molecular packing in condensed phases. Here, we synthesized the enantiopure, racemic, and achiral isomers of p‐type small molecule, that is, indacenodithieno[3,2‐b]thiophene, to understand the impact of ...
Meenal Kataria, Masaki Nobuoka, Yusuke Tsutsui, Takayuki Tanaka, Rajendra Prasad Paitandi, Yuta Takemasa, Wookjin Choi, Shu Seki   +7 more
doaj   +1 more source

Exploring the World of Double Nanohoops

Angewandte Chemie International Edition, EarlyView.
As two conjugated nanohoops covalently linked by a central unit, double nanohoops are a relatively new class of strained nanocarbons with different properties to single nanohoops. This review gives an overview of all reported double nanohoops, categorizing their structures, syntheses, and discussing properties and applications. Creativity and synthetic
Luisa Rzesny, Philipp Seitz, Birgit Esser   +2 more
wiley   +1 more source

Comparative Study Related to Cardiovascular Safety between Bupivacaine (S75-R25) and Ropivacaine in Brachial Plexus Block

Brazilian Journal of Anesthesiology, 2013
Background and objectives Bupivacaine is a first choice for regional anesthesia considering its effectiveness, long duration and less motor blockade.
Adilson Hamaji, Marcelo Rosa de Rezende, Rames Mattar, Jr., Joaquim Edson Vieira, José Otávio Costa Auler, Jr.   +4 more
doaj   +1 more source

THE STEREOCHEMISTRY AND CONFORMATION OF LIGNIN AS JUDGED BY X-RAY CRYSTALLOGRAPHIC INVESTIGATIONS OF LIGNIN MODEL COMPOUNDS: ARYLGLYCEROL BETA-GUAIACYL ETHERS

BioResources, 2007
The conformations of a variety of crystalline lignin models representing different diastereomeric forms of structural elements in lignin of the arylglycerol -guaiacyl ether type have been studied using X-ray crystallography.
Jim Parkås, Knut Lundquist, Vratislav Langer   +2 more
doaj  

Stereoisomeric engineering mediated zinc metal electrodeposition: Critical balance of solvation and adsorption capability

Advanced Powder Materials
The exceptional electrochemical performance of zinc anodes is frequently impeded by inadequate deposition kinetics and interfacial chemistry. Herein, we introduce the stereoisomerism to inform the balanced selection of electrolyte additives, taking into ...
Wen Liu, Qiwen Zhao, Ruheng Jiang, Xuyan Ni, Tiancheng You, Canglong Li, Yanzi Deng, Bingang Xu, Yuejiao Chen, Libao Chen   +9 more
doaj   +1 more source

Impact of different stereoisomers of inositol on insulin sensitivity of gestational diabetes mellitus patients

, 2021
Jing He, Yanli Zhang, Liping Wang, Xiaochun Liu   +3 more
openalex   +2 more sources