Results 121 to 130 of about 43,028 (255)
MedComm, Volume 7, Issue 10, October 2026.This review systematically covers three core dimensions of brown adipose tissue (BAT): multilayered regulatory mechanisms governing brown adipocyte differentiation and phenotypic identity, physiological functions and signaling pathways in mediating thermogenesis and systemic metabolic crosstalk between BAT and multiple organs, and emerging clinical in ...
Xiaoli Deng +4 more
wiley +1 more source
Aging Cell, Volume 25, Issue 10, October 2026.Elderly human donor microbiota disrupts intestinal barrier integrity and reshapes host metabolic and mucosal transcriptional profiles in human microbiota‐associated pigs. Integrated multi‐omics analyses identify coordinated microbial, metabolic, and host alterations associated with age‐related intestinal decline.
Jiaxin Wang +19 more
wiley +1 more source
Protective Role of Physical Activity and Antioxidant Systems During Spermatogenesis
BiomoleculesOxidative stress is a significant factor that contributes to male infertility and sperm dysfunction. In this condition, an increase in ROS production exceeds the body’s antioxidant defenses, resulting in a decline in spermatozoa quality and fertilizing ...
Cristina Antinozzi +5 more
doaj +1 more source
Clinical Endocrinology, Volume 105, Issue 4, Page 452-463, October 2026.ABSTRACT Objective Evaluate the effects of osilodrostat short‐ and long‐term treatment on health‐related quality of life (HRQoL) in Cushing's disease. Design LINC 3 and LINC 4 studies (pooled analysis). Patients 185 patients (mean baseline total scores: Cushing's Quality of Life [CushingQoL], 44.0; Beck Depression Inventory II [BDI‐II], 15.6; EuroQol ...
John Newell‐Price +6 more
wiley +1 more source
Liver cirrhosis is associated with altered glucocorticoid metabolism related to disease severity
Journal of Internal Medicine, Volume 300, Issue 4, Page 513-527, October 2026.Abstract Background Liver cirrhosis (LC) is frequently complicated by adrenal dysfunction; however, whether cirrhosis drives the coordinated, pathway‐specific reprogramming of cortisol metabolism remains unclear. Objectives We aimed to characterize axis‐specific alterations in cortisol metabolism in patients with LC, those with adrenal insufficiency ...
Soyeon Park +8 more
wiley +1 more source
The FASEB Journal, Volume 40, Issue 18, 30 September 2026.Bidirectional communication between oocytes and granulosa cells undergoes progressive remodeling during bovine folliculogenesis. Integrative transcriptomic analysis identified stage‐specific ligand‐receptor signaling networks coordinating structural, metabolic, and developmental processes.
Noemi Monferini +6 more
wiley +1 more source
Immunological Features of Neuroendocrine Neoplasms and Adrenal Tumors
Cancer Medicine, Volume 15, Issue 9, September 2026.ABSTRACT Neuroendocrine neoplasms, which occur throughout the human body, as well as adrenocortical carcinoma and pheochromocytoma, which originate in the adrenal gland, are primarily classified as rare malignancies. Immunotherapy, including immune checkpoint inhibitors (ICIs), is generally not incorporated into the standard care protocols for these ...
Akihiro Ohmoto +2 more
wiley +1 more source
Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.Xylopia aethiopica fruit extract modulates progesterone and estradiol levels in monosodium glutamate‐induced uterine fibroid models. In silico analyses reveal strong binding of its phytochemicals to progesterone, estrogen, VEGFR2, and TGF‐β receptors, indicating multi‐target anti‐fibroid actions involving hormonal regulation, anti‐angiogenesis, and ...
Adedokun Oluwasegun +7 more
wiley +1 more source
Jacobs Syndrome Presenting With Delayed Puberty and Central Hypogonadism: A Rare Case Report
Clinical Case Reports, Volume 14, Issue 9, September 2026.ABSTRACT In some rare instances, patients with 47,XYY syndrome can be short in height, accompanied by hypogonadism without the characteristic tall stature. In cases where there is delayed puberty and unusual growth pattern, a complete endocrine work‐up, including GnRH and hCG stimulation tests, along with chromosome studies, is vital.
Muhammad Hassaan Javaid +4 more
wiley +1 more source
Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.The molecular mechanisms contributing to impaired fertility in HIV+ males remain poorly defined. Using a human immunodeficiency virus (HIV) transgenic (Tg) rat model, we demonstrate key structural and functional sperm regulators including cation channel of sperm (CatSper)1–4 channels and mitochondrial biogenesis genes were markedly downregulated ...
Tousif Ahmed Hediyal +12 more
wiley +1 more source