Results 161 to 170 of about 31,449 (215)
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Transient intermediates in steroidogenesis
Journal of Steroid Biochemistry, 1975Abstract Analogs of cholesterol and pregnenolone have been synthesized and tested as hormonal precursors. Homologues of cholesterol in which C-22 is completely substituted (e.g. (20R-20-t-butyl)-5-pregnene-3)β,20 diol, (20R)-20-(phenyl)-5-pregnene-3β,20 diol) were incubated with acetone powders of adrenal glands and appropriate cofactors and each was
R B, Hochberg +3 more
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Steroidogenesis in testicular cells
Journal of Steroid Biochemistry, 1979Abstract The current state of knowledge concerning steroid biosynthesis and metabolism in isolated testicular cells is discussed. Data demonstrating conversion of progesterone to testosterone and 5α-reduced androgens in cultures of pure Sertoli cells derived from adult rat testes is presented.
E, Steinberger +2 more
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Role of the Cytoskeleton in Steroidogenesis
Endocrine, Metabolic & Immune Disorders - Drug Targets, 2022:Steroidogenesis in the adrenal cortex or gonads is a complicated process modulated by various elements either at the tissue or molecular level. The substrate cholesterol is first delivered to the outer membrane of mitochondria, undergoing a series of enzymatic reactions along with the material exchange between the mitochondria and the ER (endoplasmic ...
Zaichao Wu, Chunping Zhang
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2017
Testosterone is the major androgen in circulation in male humans produced primarily in the Leydig cells of the testis. Biosynthesis of testosterone from cholesterol occurs via a series of enzymatic reactions. Testosterone may be further metabolized into a more potent androgen dihydrotestosterone.
Christa E. Flück, Amit V. Pandey
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Testosterone is the major androgen in circulation in male humans produced primarily in the Leydig cells of the testis. Biosynthesis of testosterone from cholesterol occurs via a series of enzymatic reactions. Testosterone may be further metabolized into a more potent androgen dihydrotestosterone.
Christa E. Flück, Amit V. Pandey
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The development of steroidogenesis
The American Journal of Medicine, 1972Abstract Early in human development steroid-producing cells appear; the first of these are the trophoblastic cells of the placenta. Although active in the production of progesterone and estrogens, the syncytiotrophoblast lacks several key enzymes in steroid metabolism and therefore the placenta is an incomplete steroidogenic tissue.
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