Results 91 to 100 of about 31,144 (246)

Bactericidal, Bacteriostatic, and Fungicidal Activities of Clausena anisata Fruit and Its Compounds, Stigmasteryl 3‐Palmitate (a Phytosterol Ester) and Phellopterin (a Furanocoumarin), Against Some Clinical Pathogens

MicrobiologyOpen, Volume 15, Issue 2, April 2026.
C. anisata fruit extract and its compounds demonstrated potent broad‐spectrum antimicrobial activity, notably against Klebsiella pneumoniae (MIC 0.625 mg/mL; MLC 2.5 mg/mL) and Candida albicans (MIC 0.0781 mg/mL; MLC 0.625 mg/mL). The findings highlight promising bactericidal and fungicidal potential of stigmasteryl 3‐palmitate and phellopterin against
Emmanuel Kofi Kumatia, Alex Asase, Prince Kyei Baffour, Borge Leth Frimpong, Ernest Agyei, Nguyen Huu Tung   +5 more
wiley   +1 more source

Elucidating the mechanism of stigmasterol in acute pancreatitis treatment: insights from network pharmacology and in vitro/in vivo experiments

Frontiers in Pharmacology
IntroductionAcute pancreatitis (AP) is a severe inflammatory disease of the pancreas that could trigger a systemic inflammation and multi-organ dysfunction.
Xuanlin Zhao, Fan Li, Ao Wen, Xiuxian Yu, Xinrui Xu, Chengyu Wan, Yu Cao, Guang Xin, Wen Huang   +8 more
doaj   +1 more source

Synergistic Dose Permutation of Isolated Alkaloid and Sterol for Anticancer Effect on Young Swiss Albino Mice

Drug Design, Development and Therapy, 2021
Nada H Aljarba,1,* Huma Ali,2,3,* Saad Alkahtani4 1Department of Biology, College of Science, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia; 2Department of Chemistry, Maulana Azad National Institute of Technology, Bhopal ...
Aljarba NH, Ali H, Alkahtani S
doaj  

Senescence‐Driven Remodeling Defines an Aggressive and Immunomodulatory Subtype of Endometriosis

Aging Cell, Volume 25, Issue 4, April 2026.
Senescence in ectopic endometrial cells promotes SASP‐mediated M2 macrophage polarization and enhanced invasiveness of endometriotic lesions. PAK4 drives this process via PI3K/AKT signaling, while stigmasterol suppresses PAK4 and alleviates senescence‐associated immune remodeling. ABSTRACT Endometriosis is a benign yet invasive disease characterized by
Jingchun Liu, Wuyue Han, Jianming Tang, Huanzhi Wan, Haoyu Wang, Jiaxin Peng, Wenjing Ma, Min Hu, Li Hong   +8 more
wiley   +1 more source

Stigmasterol: a phytosterol with potential anti-osteoarthritic properties [PDF]

Osteoarthritis and Cartilage, 2010
Although most studies have focused on the cholesterol-lowering activity of stigmasterol, other bioactivities have been ascribed to this plant sterol compound, one of which is a potential anti-inflammatory effect. To investigate the effects of stigmasterol, a plant sterol, on the inflammatory mediators and metalloproteinases produced by chondrocytes.We ...
Gabay, O., Sanchez, Carmen Navarro, Salvat, C., Chevy, F., Breton, M., Nourissat, G., Wolf, C., Jacques, C., Berenbaum, F.   +8 more
openaire   +3 more sources

Wine‐Processed Cornus officinalis Ameliorates Osteoarthritis via Modulating M1/M2 Macrophage Polarization

Journal of Cellular and Molecular Medicine, Volume 30, Issue 7, April 2026.
ABSTRACT Cornus officinalis (CO) is a traditional herbal medicine renowned in Traditional Chinese Medicine (TCM) for its properties of tonifying the liver and kidney and replenishing vital essence. Meanwhile, wine‐processed CO (pCO) exhibits superior pharmacological effects, including anti‐inflammatory, antioxidant and anti‐fibrotic activities. However,
Yongsheng Fu, Minghua Zhao, Xudong Huang, Yingchao Ren, Weiguo Wang   +4 more
wiley   +1 more source

Structural and Functional Characterization of EXPO‐Derived Extracellular Vesicles in Plants

Advanced Science, Volume 13, Issue 14, 9 March 2026.
In this study, 3D electron tomography (ET), cryo‐ET, and immunogold transmission electron microscopy (TEM) are employed to characterize plant extracellular vesicles (EVs) under physiological conditions. EVs are classified into three distinct categories according to their size, content, and molecular‐marker profiles. Furthermore, Exo70E2‐positive medium
Jiayang Gao, Yanbin Li, Shengqi Zhang, Yilin He, Zhiqi Liu, Juan Wang, Jingmin Hua, Jinyu Chen, Junru Zhong, Huan Zhong, Yiji Xia, Yong Cui, Liwen Jiang   +12 more
wiley   +1 more source

Vitex Simplicifolia Abates Cadmium‐Induced Cardiotoxicity Through Antioxidant Activity and Keap1 Targeting

Chemistry &Biodiversity, Volume 23, Issue 3, March 2026.
ABSTRACT This study evaluated the cardioprotective potential of Vitex simplicifolia methanol extract (VSME) and explored its underlying mechanisms of action. Twenty‐five male rats were assigned to five groups (n = 5). Group 1 served as the normal control, while groups 2–5 were exposed to 5 mg/kg body weight of cadmium chloride (CdCl2) daily.
Ifeoma F. Chukwuma, Okechukwu Ignatius Eze, Ogechukwu Colet Okeke, Victor O. Apeh, Timothy Prince Chidike Ezeorba, Chima Okafor   +5 more
wiley   +1 more source

Isolation and evaluation of anticancer efficacy of stigmasterol in a mouse model of DMBA-induced skin carcinoma

Drug Design, Development and Therapy, 2015
Huma Ali,1 Savita Dixit,1 Daoud Ali,2 Saeed M Alqahtani,3 Saad Alkahtani,2 Saud Alarifi2 1Department of Chemistry, Maulana Azad National Institute of Technology, Bhopal, India; 2Department of Zoology, College of Science, King Saud University, Riyadh ...
Ali H, Dixit S, Ali D, Alqahtani SM, Alkahtani S, Alarifi S   +5 more
doaj  

Bio-guided isolation and bioinformatic studies of cytotoxic phytosterols from Acanthospermum hispidum DC against breast (MCF7) and colorectal (HT29) cancer cells

Arab Journal of Basic and Applied Sciences
Acanthospermum hispidum DC (Asteraceae), a traditional medicinal plant, plays a role as an alternative remedy for various diseases, such as bacterial and viral infections, jaundice, malaria, fever, gastrointestinal disorders, headache, convulsions, and ...
Alshaimaa A. Alnoor, Ashraf N. Abdalla, Fatma M. Abdel Bar, Omer Abdalla Ahmed Hamdi, Mohamed E. Elzubier, Hanaa H. A. Mohmed, Ayman A. Salkini, Masaki Kuse, Ehssan Moglad, Amira Mira   +9 more
doaj   +1 more source